ENSMUSG00000029512
Mus musculus protein Ulk1 kinase binding serine site phosphorylation complex assembly membrane increased threonine-protein ulk autophagy autophagosome extrinsic component activity domain atp macroautophagy neuron projection development regulation exchange phagophore rab gtpase mean corpuscular
Features See expression report in BioGPS See gene description in Wikigenes See co-cited genes in PubMed Ortholog prediction (from Ensembl )Paralog prediction (from Ensembl ) Ulk2 / Q9QY01 / unc-51 like kinase 2 / Q8IYT8* / unc-51 like autophagy activating kinase 2* ENSMUSG00000004798 53 Ikbkb / inhibitor of kappaB kinase beta / O14920* / inhibitor of nuclear factor kappa B kinase subunit beta* ENSMUSG00000031537 15 Ulk3 / Q3U3Q1 / unc-51-like kinase 3 / Q6PHR2* ENSMUSG00000032308 15 Ikbke / Q9R0T8 / Inhibitor of nuclear factor kappa-B kinase subunit epsilon / Q14164* ENSMUSG00000042349 14 Chuk / conserved helix-loop-helix ubiquitous kinase / O15111* ENSMUSG00000025199 13 Tbk1 / Q9WUN2 / TANK-binding kinase 1 / Q9UHD2* ENSMUSG00000020115 11
Protein motifs (from Interpro ) IPR000719 Protein kinase domain IPR008271 Serine/threonine-protein kinase, active site IPR011009 Protein kinase-like domain superfamily IPR016237 Serine/threonine-protein kinase, Ulk1/Ulk2 IPR017441 Protein kinase, ATP binding site IPR022708 Serine/threonine-protein kinase, C-terminal
Gene Ontology (GO ) nitrogen compound metabolic process cellular metabolic process primary metabolic process organic substance metabolic process catabolic process process utilizing autophagic mechanism cell communication cellular response to stimulus cellular component organization anatomical structure development cellular developmental process macromolecule localization response to stress cellular component biogenesis interspecies interaction between organisms nitrogen compound metabolic process cellular metabolic process primary metabolic process organic substance metabolic process catabolic process process utilizing autophagic mechanism cell communication cellular response to stimulus cellular component organization anatomical structure development cellular developmental process macromolecule localization response to stress cellular component biogenesis interspecies interaction between organisms nitrogen compound metabolic process cellular metabolic process primary metabolic process organic substance metabolic process catabolic process process utilizing autophagic mechanism cell communication cellular response to stimulus cellular component organization anatomical structure development cellular developmental process macromolecule localization response to stress cellular component biogenesis interspecies interaction between organisms nitrogen compound metabolic process cellular metabolic process primary metabolic process organic substance metabolic process catabolic process process utilizing autophagic mechanism cell communication cellular response to stimulus cellular component organization anatomical structure development cellular developmental process macromolecule localization response to stress cellular component biogenesis interspecies interaction between organisms nitrogen compound metabolic process cellular metabolic process primary metabolic process organic substance metabolic process catabolic process process utilizing autophagic mechanism cell communication cellular response to stimulus cellular component organization anatomical structure development cellular developmental process macromolecule localization response to stress cellular component biogenesis interspecies interaction between organisms nitrogen compound metabolic process cellular metabolic process primary metabolic process organic substance metabolic process catabolic process process utilizing autophagic mechanism cell communication cellular response to stimulus cellular component organization anatomical structure development cellular developmental process macromolecule localization response to stress cellular component biogenesis interspecies interaction between organisms nitrogen compound metabolic process cellular metabolic process primary metabolic process organic substance metabolic process catabolic process process utilizing autophagic mechanism cell communication cellular response to stimulus cellular component organization anatomical structure development cellular developmental process macromolecule localization response to stress cellular component biogenesis interspecies interaction between organisms nitrogen compound metabolic process cellular metabolic process primary metabolic process organic substance metabolic process catabolic process process utilizing autophagic mechanism cell communication cellular response to stimulus cellular component organization anatomical structure development cellular developmental process macromolecule localization response to stress cellular component biogenesis interspecies interaction between organisms nitrogen compound metabolic process cellular metabolic process primary metabolic process organic substance metabolic process catabolic process process utilizing autophagic mechanism cell communication cellular response to stimulus cellular component organization anatomical structure development cellular developmental process macromolecule localization response to stress cellular component biogenesis interspecies interaction between organisms nitrogen compound metabolic process cellular metabolic process primary metabolic process organic substance metabolic process catabolic process process utilizing autophagic mechanism cell communication cellular response to stimulus cellular component organization anatomical structure development cellular developmental process macromolecule localization response to stress cellular component biogenesis interspecies interaction between organisms nitrogen nitrogen compound metabolic process cellular cellular metabolic process primary mprimary metabolic process organic sorganic substance metabolic process cataboliccatabolic process process uprocess utilizing autophagic mechanism cell commcell communication cellular cellular response to stimulus cellular cellular component organization anatomicaanatomical structure development cellular cellular developmental process macromolemacromolecule localization response response to stress cellular cellular component biogenesis interspecinterspecies interaction between organisms catalytic activity, acting on a protein transferase activity ion binding carbohydrate derivative binding organic cyclic compound binding heterocyclic compound binding small molecule binding drug binding protein binding protein-containing complex binding catalytic activity, acting on a protein transferase activity ion binding carbohydrate derivative binding organic cyclic compound binding heterocyclic compound binding small molecule binding drug binding protein binding protein-containing complex binding catalytic activity, acting on a protein transferase activity ion binding carbohydrate derivative binding organic cyclic compound binding heterocyclic compound binding small molecule binding drug binding protein binding protein-containing complex binding catalytic activity, acting on a protein transferase activity ion binding carbohydrate derivative binding organic cyclic compound binding heterocyclic compound binding small molecule binding drug binding protein binding protein-containing complex binding catalytic activity, acting on a protein transferase activity ion binding carbohydrate derivative binding organic cyclic compound binding heterocyclic compound binding small molecule binding drug binding protein binding protein-containing complex binding catalytic activity, acting on a protein transferase activity ion binding carbohydrate derivative binding organic cyclic compound binding heterocyclic compound binding small molecule binding drug binding protein binding protein-containing complex binding catalytic activity, acting on a protein transferase activity ion binding carbohydrate derivative binding organic cyclic compound binding heterocyclic compound binding small molecule binding drug binding protein binding protein-containing complex binding catalytic activity, acting on a protein transferase activity ion binding carbohydrate derivative binding organic cyclic compound binding heterocyclic compound binding small molecule binding drug binding protein binding protein-containing complex binding catalytic activity, acting on a protein transferase activity ion binding carbohydrate derivative binding organic cyclic compound binding heterocyclic compound binding small molecule binding drug binding protein binding protein-containing complex binding catalytic activity, acting on a protein transferase activity ion binding carbohydrate derivative binding organic cyclic compound binding heterocyclic compound binding small molecule binding drug binding protein binding protein-containing complex binding catalytic acticatalytic activity, acting on a protein transferase actransferase activity ion bindingion binding carbohydrate dcarbohydrate derivative binding organic cyclicorganic cyclic compound binding heterocyclic cheterocyclic compound binding small moleculesmall molecule binding drug bindingdrug binding protein bindinprotein binding protein-contaiprotein-containing complex binding cell organelle protein-containing complex membrane cell organelle protein-containing complex membrane cell organelle protein-containing complex membrane cell organelle protein-containing complex membrane cell organelle protein-containing complex membrane cell organelle protein-containing complex membrane cell organelle protein-containing complex membrane cell organelle protein-containing complex membrane cell organelle protein-containing complex membrane cell organelle protein-containing complex membrane cellcell organelleorganelle protein-containing complexprotein-containing complex membranemembrane
Pathways (from Reactome )Phenotype (from MGI , Zfin or HPO ) hematopoietic system phenotype immune system phenotype cellular phenotype mortality/aging hematopoietic system phenotype immune system phenotype cellular phenotype mortality/aging hematopoietic system phenotype immune system phenotype cellular phenotype mortality/aging hematopoietic system phenotype immune system phenotype cellular phenotype mortality/aging hematopoietic system phenotype immune system phenotype cellular phenotype mortality/aging hematopoietic system phenotype immune system phenotype cellular phenotype mortality/aging hematopoietic system phenotype immune system phenotype cellular phenotype mortality/aging hematopoietic system phenotype immune system phenotype cellular phenotype mortality/aging hematopoietic system phenotype immune system phenotype cellular phenotype mortality/aging hematopoietic system phenotype immune system phenotype cellular phenotype mortality/aging hematopoietic system phenotypehematopoietic system phenotype immune system phenotypeimmune system phenotype cellular phenotypecellular phenotype mortality/agingmortality/aging MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Tbx4tm1.1Kng /Tbx4+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2
MP:0002424 abnormal reticulocyte morphology/development "anomalous structure, formation, or numbers of immature erthrocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tbx4tm1.1Kng /Tbx4+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2
MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tbx4tm1.1Kng /Tbx4+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2
MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tbx4tm1.1Kng /Tbx4+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2
MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Tbx4tm1.1Kng /Tbx4+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2
MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tbx4tm1.1Kng /Tbx4+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2
MP:0005641 increased mean corpuscular hemoglobin concentration "greater than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:8936]
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Allelic Composition: Tbx4tm1.1Kng /Tbx4+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2
MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tbx4tm1.1Kng /Tbx4+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2
MP:0008260 abnormal autophagy "abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"]
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Allelic Composition: Tbx4tm1.1Kng /Tbx4+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2
MP:0010067 increased red blood cell distribution width "higher than normal coefficient of variance (reference range) of the red blood cell volume for an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", NCI:C64800 "NCI Thesaurus (Code C64800)"]
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Allelic Composition: Tbx4tm1.1Kng /Tbx4+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2
MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Kcnn2bc-9J /Kcnn2bc-9J Genetic Background: C57BL/6J-bc9J /GrsrJ
Interacting proteins (from Reactome ) ENSMUSG00000004771 P62492 / Rab11a / RAB11A, member RAS oncogene family / P62491* / complex / reaction ENSMUSG00000025907 Q9ESK9 / Rb1cc1 / RB1-inducible coiled-coil protein 1 / Q8TDY2* / RB1 inducible coiled-coil 1* / complex ENSMUSG00000029513 Prkab1 / Q9R078 / protein kinase, AMP-activated, beta 1 non-catalytic subunit / Q9Y478* / protein kinase AMP-activated non-catalytic subunit beta 1* / complex / reaction ENSMUSG00000028945 Rheb / Q921J2 / Ras homolog enriched in brain / Q15382* / Ras homolog, mTORC1 binding* / complex / reaction ENSMUSG00000028944 Prkag2 / Q91WG5 / protein kinase, AMP-activated, gamma 2 non-catalytic subunit / Q9UGJ0* / protein kinase AMP-activated non-catalytic subunit gamma 2* / complex / reaction ENSMUSG00000028518 Prkaa2 / Q8BRK8 / protein kinase, AMP-activated, alpha 2 catalytic subunit / P54646* / protein kinase AMP-activated catalytic subunit alpha 2* / complex / reaction ENSMUSG00000028278 Rragd / Ras-related GTP binding D / Q9NQL2* / complex / reaction ENSMUSG00000020483 Dynll2 / Q9D0M5 / Dynein light chain 2, cytoplasmic / Q96FJ2* / dynein light chain LC8-type 2* / reaction ENSMUSG00000025040 Fundc1 / Q9DB70 / FUN14 domain-containing protein 1 / Q8IVP5* / FUN14 domain containing 1* / reaction ENSMUSG00000036661 A2RT67 / Dennd3 / DENN domain-containing protein 3 / A2RUS2* / DENN domain containing 3* / reaction ENSMUSG00000028646 Rragc / Q99K70 / Ras-related GTP-binding protein C / Q9HB90* / Ras related GTP binding C* / complex / reaction ENSMUSG00000037526 Atg14 / Q8CDJ3 / Beclin 1-associated autophagy-related key regulator / Q6ZNE5* / autophagy related 14* / reaction ENSMUSG00000035086 Becn1 / O88597 / Beclin-1 Beclin-1-C 35 kDa Beclin-1-C 37 kDa / Q14457* / beclin 1* / reaction ENSMUSG00000041658 Rragb / Q6NTA4 / Ras-related GTP-binding protein B / Q5VZM2* / Ras related GTP binding B* / complex / reaction ENSMUSG00000027244 Atg13 / Q91YI1 / Mus musculus autophagy related 13 (Atg13), transcript variant 4, mRNA. / O75143* / autophagy related 13* / complex ENSMUSG00000040506 A2AH22 / Ambra1 / Activating molecule in BECN1-regulated autophagy protein 1 / Q9C0C7* / autophagy and beclin 1 regulator 1* / reaction ENSMUSG00000050697 Prkaa1 / Q5EG47 / protein kinase, AMP-activated, alpha 1 catalytic subunit / Q13131* / protein kinase AMP-activated catalytic subunit alpha 1* / complex / reaction ENSMUSG00000038205 Prkab2 / Q6PAM0 / protein kinase, AMP-activated, beta 2 non-catalytic subunit / O43741* / protein kinase AMP-activated non-catalytic subunit beta 2* / complex / reaction ENSMUSG00000037204 Atg101 / Q9D8Z6 / Autophagy-related protein 101 / Q9BSB4* / autophagy related 101* / complex ENSMUSG00000028991 Mtor / Q9JLN9 / Serine/threonine-protein kinase mTOR / P42345* / mechanistic target of rapamycin kinase* / complex / reaction ENSMUSG00000032571 Pik3r4 / Q8VD65 / Phosphoinositide 3-kinase regulatory subunit 4 / Q99570* / reaction ENSMUSG00000047789 Q8BGD6 / Slc38a9 / Sodium-coupled neutral amino acid transporter 9 / Q8NBW4* / solute carrier family 38 member 9* / complex / reaction ENSMUSG00000024142 Mlst8 / Q9DCJ1 / Target of rapamycin complex subunit LST8 / Q9BVC4* / MTOR associated protein, LST8 homolog* / complex / reaction ENSMUSG00000006542 Prkag3 / Q8BGM7 / protein kinase, AMP-activated, gamma 3 non-catatlytic subunit / Q9UGI9* / protein kinase AMP-activated non-catalytic subunit gamma 3* / complex / reaction ENSMUSG00000033628 Pik3c3 / Q6PF93 / Phosphatidylinositol 3-kinase catalytic subunit type 3 / Q8NEB9* / reaction ENSMUSG00000070934 Rraga / Q80X95 / Ras-related GTP-binding protein A / Q7L523* / Ras related GTP binding A* / complex / reaction ENSMUSG00000064063 BC048507 / cDNA sequence BC048507 / DYNLL1* / P63167* / dynein light chain LC8-type 1* / reaction ENSMUSG00000067713 O54950 / Prkag1 / protein kinase, AMP-activated, gamma 1 non-catalytic subunit / P54619* / protein kinase AMP-activated non-catalytic subunit gamma 1* / complex / reaction ENSMUSG00000077450 P46638 / Rab11b / RAB11B, member RAS oncogene family / Q15907* / complex / reaction
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