ENSMUSG00000041658


Mus musculus

Features
Gene ID: ENSMUSG00000041658
  
Biological name :Rragb
  
Synonyms : Q6NTA4 / Ras-related GTP-binding protein B / Rragb
  
Possible biological names infered from orthology : Q5VZM2 / Ras related GTP binding B
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: F3
Gene start: 153139981
Gene end: 153171943
  
Corresponding Affymetrix probe sets: 10602692 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000039013
Ensembl peptide - ENSMUSP00000134162
NCBI entrez gene - 245670     See in Manteia.
MGI - MGI:3038613
RefSeq - XM_006528851
RefSeq - NM_001004154
RefSeq - XM_006528849
RefSeq - XM_006528850
RefSeq Peptide - NP_001004154
swissprot - G3UYP1
swissprot - Q6NTA4
Ensembl - ENSMUSG00000041658
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rragaENSDARG00000104149Danio rerio
 ENSGALG00000041226Gallus gallus
 RRAGBENSG00000083750Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rraga / Q80X95 / Ras-related GTP-binding protein A / Q7L523* / Ras related GTP binding A*ENSMUSG0000007093482


Protein motifs (from Interpro)
Interpro ID Name
 IPR006762  Gtr1/RagA G protein
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0009267 cellular response to starvation IBA
 biological_processGO:0010506 regulation of autophagy IBA
 biological_processGO:0032006 regulation of TOR signaling IEA
 biological_processGO:0032008 positive regulation of TOR signaling IEA
 biological_processGO:0034198 cellular response to amino acid starvation IEA
 biological_processGO:0034613 cellular protein localization IEA
 biological_processGO:0071230 cellular response to amino acid stimulus IEA
 biological_processGO:1904263 positive regulation of TORC1 signaling IEA
 biological_processGO:1990253 cellular response to leucine starvation IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005764 lysosome IBA
 cellular_componentGO:0034448 EGO complex IBA
 cellular_componentGO:1990131 Gtr1-Gtr2 GTPase complex IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0032561 guanyl ribonucleotide binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0051020 GTPase binding IEA


Pathways (from Reactome)
Pathway description
Macroautophagy
mTOR signalling
mTORC1-mediated signalling
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
Regulation of PTEN gene transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001729 Akt1 / P31750 / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA. / P31749* / AKT serine/threonine kinase 1*  / reaction
 ENSMUSG00000018326 Ywhab / Q9CQV8 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide / P31946* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta*  / complex / reaction
 ENSMUSG00000025907 Q9ESK9 / Rb1cc1 / RB1-inducible coiled-coil protein 1 / Q8TDY2* / RB1 inducible coiled-coil 1*  / complex / reaction
 ENSMUSG00000029513 Prkab1 / Q9R078 / protein kinase, AMP-activated, beta 1 non-catalytic subunit / Q9Y478* / protein kinase AMP-activated non-catalytic subunit beta 1*  / reaction
 ENSMUSG00000028945 Rheb / Q921J2 / Ras homolog enriched in brain / Q15382* / Ras homolog, mTORC1 binding*  / complex / reaction
 ENSMUSG00000028944 Prkag2 / Q91WG5 / protein kinase, AMP-activated, gamma 2 non-catalytic subunit / Q9UGJ0* / protein kinase AMP-activated non-catalytic subunit gamma 2*  / reaction
 ENSMUSG00000028518 Prkaa2 / Q8BRK8 / protein kinase, AMP-activated, alpha 2 catalytic subunit / P54646* / protein kinase AMP-activated catalytic subunit alpha 2*  / reaction
 ENSMUSG00000028278 Rragd / Ras-related GTP binding D / Q9NQL2*  / complex / reaction
 ENSMUSG00000029512 Ulk1 / unc-51 like kinase 1 / O75385* / unc-51 like autophagy activating kinase 1*  / complex / reaction
 ENSMUSG00000028646 Rragc / Q99K70 / Ras-related GTP-binding protein C / Q9HB90* / Ras related GTP binding C*  / complex / reaction
 ENSMUSG00000022553 Maf1 / Q9D0U6 / Repressor of RNA polymerase III transcription MAF1 homolog / Q9H063* / MAF1 homolog, negative regulator of RNA polymerase III*  / reaction
 ENSMUSG00000027244 Atg13 / Q91YI1 / Mus musculus autophagy related 13 (Atg13), transcript variant 4, mRNA. / O75143* / autophagy related 13*  / complex / reaction
 ENSMUSG00000011096 Akt1s1 / Q9D1F4 / Proline-rich AKT1 substrate 1 / Q96B36* / AKT1 substrate 1*  / complex / reaction
 ENSMUSG00000037204 Atg101 / Q9D8Z6 / Autophagy-related protein 101 / Q9BSB4* / autophagy related 101*  / complex / reaction
 ENSMUSG00000028991 Mtor / Q9JLN9 / Serine/threonine-protein kinase mTOR / P42345* / mechanistic target of rapamycin kinase*  / complex / reaction
 ENSMUSG00000047789 Q8BGD6 / Slc38a9 / Sodium-coupled neutral amino acid transporter 9 / Q8NBW4* / solute carrier family 38 member 9*  / complex / reaction
 ENSMUSG00000024142 Mlst8 / Q9DCJ1 / Target of rapamycin complex subunit LST8 / Q9BVC4* / MTOR associated protein, LST8 homolog*  / complex / reaction
 ENSMUSG00000050697 Prkaa1 / Q5EG47 / protein kinase, AMP-activated, alpha 1 catalytic subunit / Q13131* / protein kinase AMP-activated catalytic subunit alpha 1*  / reaction
 ENSMUSG00000038205 Prkab2 / Q6PAM0 / protein kinase, AMP-activated, beta 2 non-catalytic subunit / O43741* / protein kinase AMP-activated non-catalytic subunit beta 2*  / reaction
 ENSMUSG00000006542 Prkag3 / Q8BGM7 / protein kinase, AMP-activated, gamma 3 non-catatlytic subunit / Q9UGI9* / protein kinase AMP-activated non-catalytic subunit gamma 3*  / reaction
 ENSMUSG00000067713 O54950 / Prkag1 / protein kinase, AMP-activated, gamma 1 non-catalytic subunit / P54619* / protein kinase AMP-activated non-catalytic subunit gamma 1*  / reaction






 

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