ENSMUSG00000029570


Mus musculus

Features
Gene ID: ENSMUSG00000029570
  
Biological name :Lfng
  
Synonyms : Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe / Lfng / O09010
  
Possible biological names infered from orthology : LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase / Q8NES3
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: G2
Gene start: 140607320
Gene end: 140615545
  
Corresponding Affymetrix probe sets: 10527012 (MoGene1.0st)   1420643_at (Mouse Genome 430 2.0 Array)   1449943_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000031555
NCBI entrez gene - 16848     See in Manteia.
MGI - MGI:1095413
RefSeq - NM_008494
RefSeq Peptide - NP_032520
swissprot - B2RRW2
swissprot - O09010
Ensembl - ENSMUSG00000029570
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lfngENSDARG00000037879Danio rerio
 LFNGENSGALG00000038515Gallus gallus
 LFNGENSG00000106003Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rfng / O09009 / Beta-1,3-N-acetylglucosaminyltransferase radical fringe / Q9Y644* / RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase*ENSMUSG0000002515849
Mfng / O09008 / Beta-1,3-N-acetylglucosaminyltransferase manic fringe / O00587* / MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase*ENSMUSG0000001816948


Protein motifs (from Interpro)
Interpro ID Name
 IPR003378  Fringe-like
 IPR017374  Fringe


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001541 ovarian follicle development IMP
 biological_processGO:0001756 somitogenesis IMP
 biological_processGO:0002315 marginal zone B cell differentiation IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007386 compartment pattern specification IMP
 biological_processGO:0007389 pattern specification process IEA
 biological_processGO:0008593 regulation of Notch signaling pathway IMP
 biological_processGO:0014807 regulation of somitogenesis ISO
 biological_processGO:0030217 T cell differentiation IMP
 biological_processGO:0032092 positive regulation of protein binding IDA
 biological_processGO:0036066 protein O-linked fucosylation IMP
 biological_processGO:0045747 positive regulation of Notch signaling pathway IDA
 biological_processGO:0051446 positive regulation of meiotic cell cycle IMP
 biological_processGO:1902367 negative regulation of Notch signaling pathway involved in somitogenesis IMP
 cellular_componentGO:0000139 Golgi membrane TAS
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030173 integral component of Golgi membrane IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA
 molecular_functionGO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity TAS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Rpe65tm1Tmr/Rpe65tm1Tmr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Lfngtm1Grid/Lfngtm1Grid,Rfngtm1Grid/Rfngtm1Grid
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0000140 absent pedicles "loss of part of the posteriorlateral vertebral arch of a thoracic vertebrae" [J:62022, J:62023]
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Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Ripply2tm1.1Ysa/Ripply2tm1.1Ysa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA * ICR

 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
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Allelic Composition: Mecomtm1Miku/Mecomtm1Miku,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Mfngtm1Seco/Mfngtm1Seco,Rfngtm1Tfv/Rfngtm1Tfv
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J * FVB/NJ

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J * FVB/NJ

 MP:0000153 rib bifurcation "forking or division of ribs, may be a result of partial rib fusions" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rpe65tm1Tmr/Rpe65tm1Tmr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Lfngtm1Grid/Lfngtm1Grid,Rfngtm1Grid/Rfngtm1Grid
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0000154 rib fusion "appearance of one or more ribs as a single structure" [J:62022, J:62023]
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Allelic Composition: Rpe65tm1Tmr/Rpe65tm1Tmr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Lfngtm1Grid/Lfngtm1Grid,Rfngtm1Grid/Rfngtm1Grid
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Lfngtm1Seco/Lfngtm1Seco
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S7/SvEvBrd * C57BL/6J * FVB/N)

 MP:0000480 increased number of ribs "greater than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Tg(Lfng-LFNG)1Dihz/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CBA

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Tg(Lfng-LFNG)2Dihz/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CBA

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
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Allelic Composition: Eif2ak3tm1.1Drc/Eif2ak3tm1.1Drc,Tg(Ela1-cre)16Eps/0
Genetic Background: either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * FVB)

Allelic Composition: Lfngm1Btlr/Lfngm1Btlr
Genetic Background: C57BL/6J-Lfngm1Btlr

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Tg(Lfng*-LFNG)1Dihz/Tg(Lfng*-LFNG)1Dihz
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CBA

 MP:0000592 short tail "reduced length of tail compared to control " [J:55583]
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Allelic Composition: Lfngtm1Seco/Lfngtm1Seco
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Lfngm1Btlr/Lfngm1Btlr
Genetic Background: C57BL/6J-Lfngm1Btlr

Allelic Composition: Lfngtm1.2Egan/Lfngtm1.2Egan
Genetic Background: FVB.129-Lfngtm1.2Egan

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Tg(Lfng*-LFNG)1Dihz/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CBA

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Tg(Lfng*-LFNG)2Dihz/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CBA

 MP:0000963 fused dorsal root ganglia "loss of DRG spacing pattern and the appearance of two or more ganglia as one " [J:62022, J:62023]
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Allelic Composition: Rpe65tm1Tmr/Rpe65tm1Tmr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001119 abnormal female reproductive anatomy "anomalous structure of the organs associated with producing offspring in the gender that bears the offspring" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001125 abnormal oocytes "anomalous structure of immature ova" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001129 impaired ovarian folliculogenesis "a block in the formation of the spherical ovum in the ovary" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001130 abnormal ovarian folliculogenesis "atypical formation or failure to form the spherical ovum in the ovary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:35782]
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Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001131 abnormal ovarian follicles "malformed or absent sac-like structure in the ovary which surrounds an ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
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Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Brca1tm5.1Cxd/Brca1tm5.1Cxd
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Lfngtm1.2Egan/Lfngtm1.2Egan
Genetic Background: FVB.129-Lfngtm1.2Egan

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Eif2ak3tm1.1Drc/Eif2ak3tm1.1Drc,Tg(Ela1-cre)16Eps/0
Genetic Background: either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * FVB)

 MP:0001539 decreased number of caudal vertebrae "reduced number of the bony segments of the tail" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mecomtm1Miku/Mecomtm1Miku,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Mfngtm1Seco/Mfngtm1Seco,Rfngtm1Tfv/Rfngtm1Tfv
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J * FVB/NJ

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J * FVB/NJ

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cx3cr1tm1Zm/Cx3cr1tm1Zm
Genetic Background: B6.129-Apoetm1Unc Cx3cr1tm1Zm

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Eif2ak3tm1.1Drc/Eif2ak3tm1.1Drc,Tg(Ela1-cre)16Eps/0
Genetic Background: either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * FVB)

Allelic Composition: Lfngtm1.2Egan/Lfngtm1.2Egan
Genetic Background: involves: 129 * 129S4/SvJaeSor * FVB/N

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Mesp2tm15.1(Lfng)Ysa/Mesp2+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Urostm2Rjde/Urostm3Rjde
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SKH1

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Lfngtm1Seco/Lfngtm1Seco
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Tg(Lfng-LFNG)1Dihz/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CBA

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Tg(Lfng-LFNG)2Dihz/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CBA

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Rpe65tm1Tmr/Rpe65tm1Tmr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001929 abnormal gametogenesis "defective formation or differentiation of germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:42324]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cx3cr1tm1Zm/Cx3cr1tm1Zm
Genetic Background: B6.129-Apoetm1Unc Cx3cr1tm1Zm

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J * FVB/NJ

 MP:0002114 abnormal axial skeleton morphology "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rpe65tm1Tmr/Rpe65tm1Tmr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Tg(Lfng*-LFNG)1Dihz/Tg(Lfng*-LFNG)1Dihz
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CBA

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Tg(Lfng*-LFNG)1Dihz/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CBA

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Tg(Lfng*-LFNG)2Dihz/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CBA

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lfngtm1.2Egan/Lfngtm1.2Egan
Genetic Background: FVB.129-Lfngtm1.2Egan

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Jag1tm1Jlew/Jag1tm1Grid,Tg(Pdgfb-icre/ERT2)1Frut/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0002823 abnormal rib development "anomalous formation of the bones forming the bony wall of the chest" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84754]
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Allelic Composition: Lfngtm1.2Egan/Lfngtm1.2Egan
Genetic Background: FVB.129-Lfngtm1.2Egan

 MP:0003036 vertebral transformation "homeotic transformation of a specific vertebrae to adopt the fate of another" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Tg(Lfng-LFNG)1Dihz/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CBA

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Tg(Lfng-LFNG)2Dihz/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CBA

 MP:0003047 abnormal thoracic vertebrae morphology "malformation of any or all of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Lfngtm1Seco/Lfngtm1Seco
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S7/SvEvBrd * C57BL/6J * FVB/N)

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Tg(Lfng*-LFNG)1Dihz/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CBA

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Tg(Lfng*-LFNG)2Dihz/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CBA

 MP:0003048 abnormal cervical vertebrae morphology "malformation of any or all of the seven bony segments of the spine located anterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Tg(Lfng*-LFNG)1Dihz/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CBA

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Tg(Lfng*-LFNG)2Dihz/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CBA

 MP:0003049 abnormal lumbar vertebrae morphology "malformation of any or all of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Lfngtm1Seco/Lfngtm1Seco
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S7/SvEvBrd * C57BL/6J * FVB/N)

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Tg(Lfng*-LFNG)1Dihz/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CBA

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Tg(Lfng*-LFNG)2Dihz/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CBA

 MP:0003050 abnormal sacral vertebrae morphology "malformation of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S7/SvEvBrd * C57BL/6J * FVB/N)

 MP:0003345 decreased number of ribs "fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Rpe65tm1Tmr/Rpe65tm1Tmr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003396 abnormal embryonic hematopoiesis "anomaly in the development of primarily large, nucleated erythroblasts as well as some megakaryocytes and primitive macrophages occuring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans " [J:94136, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Mfngtm1Cjg/Mfngtm1Cjg
Genetic Background: B6.Cg-Lfngtm1Rjo Mfngtm1Cjg

 MP:0004007 abnormal lung vasculature "malformation or disorganization of the blood vessels of the lung" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Lfngtm1.2Egan/Lfngtm1.2Egan
Genetic Background: FVB.129-Lfngtm1.2Egan

 MP:0004073 caudal body truncation "caudal part of body truncated with anterior portion relatively normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004396 decreased cochlear inner hair cell number "decreased number (or less than the expected single row) of the flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Fignfi/Fignfi
Genetic Background: involves: 129S1/SvImJ * C57BL/6

Allelic Composition: Jag2tm1Grid/Jag2tm1Grid,Lfngtm1Grid/Lfng+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0004399 abnormal cochlear outer hair cell morphology "any structural abnormality in the sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve; there are three rows of columnar outer hair cells largely surrounded by cortilymph and supporting phalangeal cells; the apical end of each cell is anchored to the cuticular plate and about 100 stereocilia arranged in a V-shaped pattern extend from the cell s surface through the cuticular plate into the tectorial membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Fignfi/Fignfi
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0004401 increased cochlear outer hair cell number "increased number (or more than the expected 3 rows) of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Jag2tm1Grid/Jag2tm1Grid,Lfngtm1Grid/Lfngtm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0004609 vertebral fusion "the union of one or more vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Lfngm1Btlr/Lfngm1Btlr
Genetic Background: C57BL/6J-Lfngm1Btlr

 MP:0004624 abnormal thoracic cage "any structural anomaly of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rpe65tm1Tmr/Rpe65tm1Tmr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004646 decreased cervical vertebrae number "reduced number of the seven bony segments of the spine located anterior to the thoracic vertebrae and caudal to the skull" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Rpe65tm1Tmr/Rpe65tm1Tmr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004647 decreased lumbar vertebrae number "reduced number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Tg(Lfng-LFNG)1Dihz/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CBA

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Tg(Lfng-LFNG)2Dihz/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CBA

 MP:0004651 increased thoracic vertebrae number "increased number of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Tg(Lfng-LFNG)1Dihz/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CBA

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Tg(Lfng-LFNG)2Dihz/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CBA

 MP:0004653 absent caudal vertebrae "absence of all of the bony segments of the coccyx or tail; there are usually 27-30 present in rodents and only 3-5 fused vertebrae in human" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004703 abnormal vertebral column "any structural anomaly of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Tg(Lfng*-LFNG)1Dihz/Tg(Lfng*-LFNG)1Dihz
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CBA

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Tg(Lfng*-LFNG)1Dihz/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CBA

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Tg(Lfng*-LFNG)2Dihz/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CBA

 MP:0004704 short vertebral column "decreased rostral-caudal length of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Tg(Lfng*-LFNG)1Dihz/Tg(Lfng*-LFNG)1Dihz
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CBA

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Tg(Lfng*-LFNG)1Dihz/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CBA

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Tg(Lfng*-LFNG)2Dihz/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CBA

 MP:0005168 abnormal female meiosis "malfunction in the process of nuclear division that results in ova with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005221 abnormal rostral-caudal axis patterning "anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Ripply2tm1.1Ysa/Ripply2tm1.1Ysa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA * ICR

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005222 abnormal somite size "atypical size of any of the segmental masses along the notochord of the developing embryo" [J:72325]
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Allelic Composition: Lfngtm1Seco/Lfngtm1Seco
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0005223 abnormal anterior-posterior polarity of the somites "anomalous development or formation of the somites along the axis that runs from the front to the back surface of the body " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:72325]
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Allelic Composition: Rpe65tm1Tmr/Rpe65tm1Tmr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Mesp2tm15.1(Lfng)Ysa/Mesp2+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005225 abnormal vertebrae development "anomalous formation of the vertebrae from the sclerotome" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005227 abnormal vertebral body development "anomalous formation of the main portion of the vertebra anterior to the vertebral canal, and distinct from the vertebral arch" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mecomtm1Miku/Mecomtm1Miku,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Mfngtm1Seco/Mfngtm1Seco,Rfngtm1Tfv/Rfngtm1Tfv
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J * FVB/NJ

 MP:0006027 impaired alveologenesis "a block or reduction in the generation of alveoli" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:85546]
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Allelic Composition: Lfngtm1.2Egan/Lfngtm1.2Egan
Genetic Background: involves: 129 * 129S4/SvJaeSor * FVB/N

 MP:0006029 abnormal sclerotome "malformation of the one or more of the masses of mesodermal tissue that is derived from the somites and is adjacent to the notochord that give rise to the ribs and vertebrae" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]
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Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008148 abnormal rib-sternum attachment "any anomaly in the in the normal joining of the ribs to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rpe65tm1Tmr/Rpe65tm1Tmr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008149 abnormal rib-vertebral column attachment "any anomaly in the in the normal joining of the ribs to the vertebral column" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rpe65tm1Tmr/Rpe65tm1Tmr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Lfngtm1Grid/Lfngtm1Grid,Rfngtm1Grid/Rfngtm1Grid
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0008530 abnormal rostral-caudal patterning of the somites "anomaly in the developmental pattern of the somites along the axis that runs from the head to the caudal region of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Lfngtm1Seco/Lfngtm1Seco
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S7/SvEvBrd * C57BL/6J * FVB/N)

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Mecomtm1Miku/Mecomtm1Miku,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Mfngtm1Seco/Mfngtm1Seco,Rfngtm1Tfv/Rfngtm1Tfv
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J * FVB/NJ

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J * FVB/NJ

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Tg(Lfng*-LFNG)1Dihz/Tg(Lfng*-LFNG)1Dihz
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CBA

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Tg(Lfng*-LFNG)1Dihz/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CBA

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Tg(Lfng*-LFNG)2Dihz/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CBA

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Tg(Lfng-LFNG)1Dihz/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CBA

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Tg(Lfng-LFNG)2Dihz/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CBA

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S7/SvEvBrd * C57BL/6J * FVB/N)

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Mfngtm1Seco/Mfngtm1Seco
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J * FVB/NJ

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Mfngtm1Seco/Mfngtm1Seco,Rfngtm1Tfv/Rfngtm1Tfv
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J * FVB/NJ

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J * FVB/NJ

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Rpe65tm1Tmr/Rpe65tm1Tmr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Lfngtm1.2Egan/Lfngtm1.2Egan
Genetic Background: involves: 129 * 129S4/SvJaeSor * FVB/N

 MP:0011102 partial embryonic lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo
Genetic Background: involves: 129S7/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026923 Notch1 / Q01705 / Neurogenic locus notch homolog protein 1 Notch 1 extracellular truncation Notch 1 intracellular domain / P46531*  / reaction






 

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