ENSMUSG00000029713


Mus musculus

Features
Gene ID: ENSMUSG00000029713
  
Biological name :Gnb2
  
Synonyms : Gnb2 / guanine nucleotide binding protein (G protein), beta 2 / P62880
  
Possible biological names infered from orthology : G protein subunit beta 2 / P62879
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: G2
Gene start: 137528127
Gene end: 137533510
  
Corresponding Affymetrix probe sets: 10534842 (MoGene1.0st)   1450623_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000119725
Ensembl peptide - ENSMUSP00000132908
Ensembl peptide - ENSMUSP00000129353
Ensembl peptide - ENSMUSP00000128038
Ensembl peptide - ENSMUSP00000126823
Ensembl peptide - ENSMUSP00000121942
Ensembl peptide - ENSMUSP00000031726
Ensembl peptide - ENSMUSP00000106649
Ensembl peptide - ENSMUSP00000106652
Ensembl peptide - ENSMUSP00000106656
NCBI entrez gene - 14693     See in Manteia.
MGI - MGI:95784
RefSeq - XM_006504553
RefSeq - NM_010312
RefSeq Peptide - NP_034442
swissprot - D3YZX3
swissprot - E9PWM7
swissprot - E9QKR0
swissprot - P62880
swissprot - Q3U9V4
swissprot - D3Z1M1
swissprot - D3Z1T4
Ensembl - ENSMUSG00000029713
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gnb2ENSDARG00000035357Danio rerio
 GNB2ENSG00000172354Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gnb1 / P62874 / guanine nucleotide binding protein (G protein), beta 1 / P62873* / G protein subunit beta 1*ENSMUSG0000002906490
Gnb4 / P29387 / guanine nucleotide binding protein (G protein), beta 4 / Q9HAV0* / G protein subunit beta 4*ENSMUSG0000002766989
Gnb3 / Q61011 / guanine nucleotide binding protein (G protein), beta 3 / P16520* / G protein subunit beta 3*ENSMUSG0000002343980
Gnb5 / P62881 / guanine nucleotide binding protein (G protein), beta 5 / O14775* / G protein subunit beta 5*ENSMUSG0000003219251
Wdr47 / Q8CGF6 / WD repeat domain 47 / O94967*ENSMUSG0000004038928


Protein motifs (from Interpro)
Interpro ID Name
 IPR001632  G-protein, beta subunit
 IPR001680  WD40 repeat
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016346  Guanine nucleotide-binding protein, beta subunit
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005834 heterotrimeric G-protein complex ISO
 cellular_componentGO:0043209 myelin sheath IDA
 cellular_componentGO:0044297 cell body IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISS
 molecular_functionGO:0003924 GTPase activity ISO
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005246 calcium channel regulator activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0044877 protein-containing complex binding IEA
 molecular_functionGO:0051020 GTPase binding ISO


Pathways (from Reactome)
Pathway description
Activation of G protein gated Potassium channels
Glucagon signaling in metabolic regulation
G-protein activation
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
ADP signalling through P2Y purinoceptor 12
G beta:gamma signalling through PI3Kgamma
Prostacyclin signalling through prostacyclin receptor
Adrenaline,noradrenaline inhibits insulin secretion
Ca2+ pathway
G alpha (q) signalling events
G alpha (12/13) signalling events
G beta:gamma signalling through PLC beta
G alpha (s) signalling events
ADP signalling through P2Y purinoceptor 1
G alpha (i) signalling events
G alpha (z) signalling events
Glucagon-type ligand receptors
Thromboxane signalling through TP receptor
Vasopressin regulates renal water homeostasis via Aquaporins
Thrombin signalling through proteinase activated receptors (PARs)
Presynaptic function of Kainate receptors
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025127 Gcgr / Q61606 / Glucagon receptor / P47871*  / reaction
 ENSMUSG00000024462 Gabbr1 / Q9WV18 / Gamma-aminobutyric acid type B receptor subunit 1 / Q9UBS5*  / complex
 ENSMUSG00000009030 Pdcl / Q9DBX2 / Phosducin-like protein / Q13371* / phosducin like*  / complex
 ENSMUSG00000062609 Kcnj15 / O88932 / ATP-sensitive inward rectifier potassium channel 15 / Q99712* / potassium voltage-gated channel subfamily J member 15*  / complex
 ENSMUSG00000041695 Kcnj2 / P35561 / potassium inwardly-rectifying channel, subfamily J, member 2 / P63252* / potassium voltage-gated channel subfamily J member 2*  / complex
 ENSMUSG00000032034 Kcnj5 / P48545 / G protein-activated inward rectifier potassium channel 4 / P48544* / potassium voltage-gated channel subfamily J member 5*  / complex
 ENSMUSG00000042529 Kcnj12 / P52187 / ATP-sensitive inward rectifier potassium channel 12 / Q14500* / potassium voltage-gated channel subfamily J member 12*  / complex
 ENSMUSG00000044708 Kcnj10 / Q9JM63 / ATP-sensitive inward rectifier potassium channel 10 / P78508* / potassium voltage-gated channel subfamily J member 10*  / complex
 ENSMUSG00000038026 Kcnj9 / P48543 / potassium inwardly-rectifying channel, subfamily J, member 9 / Q92806* / potassium voltage-gated channel subfamily J member 9*  / complex
 ENSMUSG00000044216 Kcnj4 / potassium voltage-gated channel subfamily J member 4 / P48050*  / complex
 ENSMUSG00000043004 Gng2 / P63213 / guanine nucleotide binding protein (G protein), gamma 2 / P59768* / G protein subunit gamma 2*  / complex / reaction
 ENSMUSG00000026824 Kcnj3 / P63250 / G protein-activated inward rectifier potassium channel 1 / P48549* / potassium voltage-gated channel subfamily J member 3*  / complex
 ENSMUSG00000027523 Gnas / Q9Z0F1 / P63094 / Q6R0H6 / Q6R0H7 / GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus / P84996* / Q5JWF2* / O95467* / P63092* / GNAS complex locus*  / complex
 ENSMUSG00000043301 Kcnj6 / G protein-activated inward rectifier potassium channel 2 isoform Girk2B / P48051* / potassium voltage-gated channel subfamily J member 6*  / complex
 ENSMUSG00000051497 Kcnj16 / Q9Z307 / Inward rectifier potassium channel 16 / Q9NPI9* / potassium voltage-gated channel subfamily J member 16*  / complex
 ENSMUSG00000039809 Gabbr2 / Q80T41 / Gamma-aminobutyric acid type B receptor subunit 2 / O75899*  / complex






 

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