Manteia

ENSMUSG00000027669

Mus musculus

Features

Gene ID:	ENSMUSG00000027669

Biological name :	Gnb4

Synonyms :	Gnb4 / guanine nucleotide binding protein (G protein), beta 4 / P29387

Possible biological names infered from orthology :	G protein subunit beta 4 / Q9HAV0

Species:	Mus musculus

Chr. number:	3
Strand:	-1
Band:	A3
Gene start:	32580332
Gene end:	32616585

Corresponding Affymetrix probe sets:	10497689 (MoGene1.0st) 1419469_at (Mouse Genome 430 2.0 Array) 1419470_at (Mouse Genome 430 2.0 Array) 1439632_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000103869 Ensembl peptide - ENSMUSP00000121127 Ensembl peptide - ENSMUSP00000138886 Ensembl peptide - ENSMUSP00000141196 NCBI entrez gene - 14696 See in Manteia. MGI - MGI:104581 RefSeq - XM_006535404 RefSeq - NM_001348062 RefSeq - NM_013531 RefSeq - XM_006535403 RefSeq Peptide - NP_001335033 RefSeq Peptide - NP_038559 RefSeq Peptide - NP_001334991 swissprot - P29387 swissprot - V9GWY1 swissprot - A0A0A6YVN9 Ensembl - ENSMUSG00000027669

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Gnb1 / P62874 / guanine nucleotide binding protein (G protein), beta 1 / P62873* / G protein subunit beta 1*	ENSMUSG00000029064	90
Gnb2 / P62880 / guanine nucleotide binding protein (G protein), beta 2 / P62879* / G protein subunit beta 2*	ENSMUSG00000029713	89
Gnb3 / Q61011 / guanine nucleotide binding protein (G protein), beta 3 / P16520* / G protein subunit beta 3*	ENSMUSG00000023439	79
Gnb5 / P62881 / guanine nucleotide binding protein (G protein), beta 5 / O14775* / G protein subunit beta 5*	ENSMUSG00000032192	52
Wdr47 / Q8CGF6 / WD repeat domain 47 / O94967*	ENSMUSG00000040389	28

Protein motifs (from Interpro)

Interpro ID	Name
IPR001632	G-protein, beta subunit
IPR001680	WD40 repeat
IPR011042	Six-bladed beta-propeller, TolB-like
IPR015943	WD40/YVTN repeat-like-containing domain superfamily
IPR016346	Guanine nucleotide-binding protein, beta subunit
IPR017986	WD40-repeat-containing domain
IPR019775	WD40 repeat, conserved site
IPR020472	G-protein beta WD-40 repeat
IPR036322	WD40-repeat-containing domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0007165	signal transduction	IEA
biological_process	GO:0007186	G-protein coupled receptor signaling pathway	TAS
cellular_component	GO:0005834	heterotrimeric G-protein complex	ISA
cellular_component	GO:0043209	myelin sheath	IDA
molecular_function	GO:0003924	GTPase activity	ISA
molecular_function	GO:0004871	obsolete signal transducer activity	IEA
molecular_function	GO:0005515	protein binding	IEA
molecular_function	GO:0044877	protein-containing complex binding	IEA

Pathways (from Reactome)

Pathway description

Glucagon signaling in metabolic regulation

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000025127	Gcgr / Q61606 / Glucagon receptor / P47871*	/ reaction
ENSMUSG00000043004	Gng2 / P63213 / guanine nucleotide binding protein (G protein), gamma 2 / P59768* / G protein subunit gamma 2*	/ reaction / complex
ENSMUSG00000009030	Pdcl / Q9DBX2 / Phosducin-like protein / Q13371* / phosducin like*	/ complex
ENSMUSG00000027523	Gnas / Q9Z0F1 / P63094 / Q6R0H6 / Q6R0H7 / GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus / P84996* / Q5JWF2* / O95467* / P63092* / GNAS complex locus*	/ complex

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr