ENSMUSG00000029736


Mus musculus

Features
Gene ID: ENSMUSG00000029736
  
Biological name :Nobox
  
Synonyms : Homeobox protein NOBOX / Nobox / Q8VIH1
  
Possible biological names infered from orthology : NOBOX oogenesis homeobox / O60393
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: B2.1
Gene start: 43303674
Gene end: 43309554
  
Corresponding Affymetrix probe sets: 10544477 (MoGene1.0st)   1425759_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000031749
Ensembl peptide - ENSMUSP00000133353
NCBI entrez gene - 18291     See in Manteia.
MGI - MGI:108011
RefSeq - NM_130869
RefSeq - XM_017321447
RefSeq Peptide - NP_570939
swissprot - G3UWN1
swissprot - Q8VIH1
Ensembl - ENSMUSG00000029736
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000043916Gallus gallus
 NOBOXENSG00000106410Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001541 ovarian follicle development IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II ISO
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048477 oogenesis IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005667 transcription factor complex IC
 cellular_componentGO:0005737 cytoplasm IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IMP
 molecular_functionGO:0043565 sequence-specific DNA binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001125 abnormal oocytes "anomalous structure of immature ova" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Slit3Gt(OST106158)Lex/Slit3Gt(OST106158)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0001129 impaired ovarian folliculogenesis "a block in the formation of the spherical ovum in the ovary" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slit3Gt(OST106158)Lex/Slit3Gt(OST106158)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0001131 abnormal ovarian follicles "malformed or absent sac-like structure in the ovary which surrounds an ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
Show

Allelic Composition: Slit3Gt(OST106158)Lex/Slit3Gt(OST106158)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nhlh2tm1b(KOMP)Mbp/Nhlh2tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Nhlh2tm1b(KOMP)Mbp/Tcp

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Slit3Gt(OST106158)Lex/Slit3Gt(OST106158)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0002016 ovarian cysts "cystic ovary; usually refers to a benign growth" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Slit3Gt(OST106158)Lex/Slit3Gt(OST106158)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0002059 abnormal seminal gland morphology "anomalous structure of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nhlh2tm1b(KOMP)Mbp/Nhlh2tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Nhlh2tm1b(KOMP)Mbp/Tcp

 MP:0003232 abnormal forebrain development "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nhlh2tm1b(KOMP)Mbp/Nhlh2tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Nhlh2tm1b(KOMP)Mbp/Tcp

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
Show

Allelic Composition: Nhlh2tm1b(KOMP)Mbp/Nhlh2tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Nhlh2tm1b(KOMP)Mbp/Tcp

 MP:0003864 abnormal midbrain development "anomaly in the formation of or the patterning of the part of the brainstem developing from the middle of the three primary cerebral vesicles of the embryo" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Nhlh2tm1b(KOMP)Mbp/Nhlh2tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Nhlh2tm1b(KOMP)Mbp/Tcp

 MP:0004805 absent oocytes "absence of mature germ cells in the female" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slit3Gt(OST106158)Lex/Slit3Gt(OST106158)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0004833 ovary atrophy "wasting of the ovary due to injury or disease resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slit3Gt(OST106158)Lex/Slit3Gt(OST106158)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0005431 oocyte depletion "reduced numbers or absence of germ cells in the female" [llw2:Linda Washburn , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Slit3Gt(OST106158)Lex/Slit3Gt(OST106158)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0006108 abnormal hindbrain development "anomaly in the formation or pattering of the caudal region of the brain" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93573]
Show

Allelic Composition: Nhlh2tm1b(KOMP)Mbp/Nhlh2tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Nhlh2tm1b(KOMP)Mbp/Tcp

 MP:0009093 oocyte degeneration "a retrogressive impairment of function or destruction of the female germ cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Slit3Gt(OST106158)Lex/Slit3Gt(OST106158)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0009363 abnormal secondary ovarian follicle morphology "any structural abnormality in the ovarian follicle in which the primary oocyte attains its full size and is surrounded by an extracellular glycoprotein layer (zona pellucida) that separates it from a peripheral layer of follicular cells permeated by one or more fluid-filled antra; the primary oocyte occupies the cumulus oophorus while the theca of the follicle develops into internal and external layers" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slit3Gt(OST106158)Lex/Slit3Gt(OST106158)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Nhlh2tm1b(KOMP)Mbp/Nhlh2tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Nhlh2tm1b(KOMP)Mbp/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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