ENSMUSG00000029992


Mus musculus

Features
Gene ID: ENSMUSG00000029992
  
Biological name :Gfpt1
  
Synonyms : Gfpt1 / Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 / P47856
  
Possible biological names infered from orthology : glutamine--fructose-6-phosphate transaminase 1 / Q06210
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: D1
Gene start: 87042846
Gene end: 87092197
  
Corresponding Affymetrix probe sets: 10539773 (MoGene1.0st)   1418904_at (Mouse Genome 430 2.0 Array)   1420080_a_at (Mouse Genome 430 2.0 Array)   1428715_at (Mouse Genome 430 2.0 Array)   1444329_at (Mouse Genome 430 2.0 Array)   1449268_at (Mouse Genome 430 2.0 Array)   1449725_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000109285
Ensembl peptide - ENSMUSP00000109288
Ensembl peptide - ENSMUSP00000109287
Ensembl peptide - ENSMUSP00000032057
NCBI entrez gene - 14583     See in Manteia.
MGI - MGI:95698
RefSeq - NM_013528
RefSeq Peptide - NP_038556
swissprot - D3YYE0
swissprot - D3YYD9
swissprot - P47856
Ensembl - ENSMUSG00000029992
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gfpt1ENSDARG00000057465Danio rerio
 GFPT1ENSGALG00000036391Gallus gallus
 GFPT1ENSG00000198380Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gfpt2 / Q9Z2Z9 / Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 / O94808* / glutamine-fructose-6-phosphate transaminase 2*ENSMUSG0000002036379


Protein motifs (from Interpro)
Interpro ID Name
 IPR001347  Sugar isomerase (SIS)
 IPR005855  Glucosamine-fructose-6-phosphate aminotransferase, isomerising
 IPR017932  Glutamine amidotransferase type 2 domain
 IPR029055  Nucleophile aminohydrolases, N-terminal
 IPR035466  GlmS/AgaS, SIS domain 1
 IPR035490  GlmS/FrlB, SIS domain 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006002 fructose 6-phosphate metabolic process IBA
 biological_processGO:0006047 UDP-N-acetylglucosamine metabolic process IBA
 biological_processGO:0006048 UDP-N-acetylglucosamine biosynthetic process IEA
 biological_processGO:0006487 protein N-linked glycosylation IBA
 biological_processGO:0006541 glutamine metabolic process IEA
 biological_processGO:0032922 circadian regulation of gene expression IMP
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:1901135 carbohydrate derivative metabolic process IEA
 biological_processGO:1901137 carbohydrate derivative biosynthetic process IEA
 molecular_functionGO:0004360 glutamine-fructose-6-phosphate transaminase (isomerizing) activity IBA
 molecular_functionGO:0008483 transaminase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0097367 carbohydrate derivative binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of UDP-N-acetyl-glucosamine


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Gbx1tm1b(KOMP)Wtsi/Gbx1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Gbx1tm1b(KOMP)Wtsi/H

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gbx1tm1b(KOMP)Wtsi/Gbx1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Gbx1tm1b(KOMP)Wtsi/H

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Gbx1tm1b(KOMP)Wtsi/Gbx1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Gbx1tm1b(KOMP)Wtsi/H

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
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Allelic Composition: Gbx1tm1b(KOMP)Wtsi/Gbx1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Gbx1tm1b(KOMP)Wtsi/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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