ENSMUSG00000030064


Mus musculus
domainFrmd4bfermsuperfamilyjunctionph-likeproteincellacyl-coa-bindingn-terminalc-terminalconservedsitecentralbandunknownfunctiondufubiquitin-likesecondestablishmentepithelialpolarityrufflecytoplasmcytoskeletonadherensbicellulartightbindingincreased

Features
Gene ID: ENSMUSG00000030064
  
Biological name :Frmd4b
  
Synonyms : Frmd4b / Mus musculus FERM domain containing 4B (Frmd4b), transcript variant 2, mRNA. / Q920B0
  
Possible biological names infered from orthology : FERM domain containing 4B / Q9Y2L6
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: D3
Gene start: 97286867
Gene end: 97617541
  
Corresponding Affymetrix probe sets: 10546631 (MoGene1.0st)   1426331_a_at (Mouse Genome 430 2.0 Array)   1426594_at (Mouse Genome 430 2.0 Array)   1438169_a_at (Mouse Genome 430 2.0 Array)   1441548_at (Mouse Genome 430 2.0 Array)   1452123_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000032146
Ensembl peptide - ENSMUSP00000108982
Ensembl peptide - ENSMUSP00000108986
Ensembl peptide - ENSMUSP00000145240
NCBI entrez gene - 232288     See in Manteia.
MGI - MGI:2141794
RefSeq - XM_017321538
RefSeq - NM_001346637
RefSeq - NM_001346639
RefSeq - NM_145148
RefSeq - XM_006506002
RefSeq - XM_006506004
RefSeq - XM_017321537
RefSeq Peptide - NP_001333566
RefSeq Peptide - NP_001333568
RefSeq Peptide - NP_660130
swissprot - Q6ZQ04
swissprot - Q920B0
swissprot - A0A0N4SVT9
Ensembl - ENSMUSG00000030064
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 frmd4baENSDARG00000074599Danio rerio
 frmd4bbENSDARG00000076496Danio rerio
 FRMD4BENSGALG00000037791Gallus gallus
 FRMD4BENSG00000114541Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Frmd4a / Q8BIE6 / Mus musculus FERM domain containing 4A (Frmd4a), transcript variant 4, mRNA. / Q9P2Q2* / FERM domain containing 4A*ENSMUSG0000002665748
5730559C18Rik / innate immunity activator / INAVA* / Q3KP66*ENSMUSG0000004160515
A2AEV7 / Ccdc120 / Coiled-coil domain-containing protein 120 / Q96HB5* / coiled-coil domain containing 120*ENSMUSG0000003115014


Protein motifs (from Interpro)
Interpro ID Name
 IPR000299  FERM domain
 IPR011993  PH-like domain superfamily
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR018979  FERM, N-terminal
 IPR018980  FERM, C-terminal PH-like domain
 IPR019747  FERM conserved site
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR021774  Domain of unknown function DUF3338
 IPR029071  Ubiquitin-like domain superfamily
 IPR035963  FERM superfamily, second domain


Gene Ontology (GO)
establishment or maintenance of cell polarityestablishment or maintenance of cell polarityestablishment or maintenance of cell polarityestablishment or maintenance of cell polarityestablishment or maintenance of cell polarityestablishment or maintenance of cell polarityestablishment or maintenance of cell polarityestablishment or maintenance of cell polarityestablishment or maintenance of cell polarityestablishment or maintenance of cell polarityestablishment or maintenance of cell polarityestablishment or maintenance of cell polarity
protein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein binding
cellorganellecell junctioncellorganellecell junctioncellorganellecell junctioncellorganellecell junctioncellorganellecell junctioncellorganellecell junctioncellorganellecell junctioncellorganellecell junctioncellorganellecell junctioncellorganellecell junctioncellcellorganelleorganellecell junctioncell junction
TypeGO IDTermEv.Code
 biological_processGO:0090162 establishment of epithelial cell polarity IGI
 cellular_componentGO:0001726 ruffle IPI
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005912 adherens junction IEA
 cellular_componentGO:0005923 bicellular tight junction IEA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
behavior/neurological phenotypeintegument phenotypebehavior/neurological phenotypeintegument phenotypebehavior/neurological phenotypeintegument phenotypebehavior/neurological phenotypeintegument phenotypebehavior/neurological phenotypeintegument phenotypebehavior/neurological phenotypeintegument phenotypebehavior/neurological phenotypeintegument phenotypebehavior/neurological phenotypeintegument phenotypebehavior/neurological phenotypeintegument phenotypebehavior/neurological phenotypeintegument phenotypebehavior/neurological phenotypebehavior/neurological phenotypeintegument phenotypeintegument phenotype
IDPhenotypeDefinition Genetic BG
 MP:0001415 increased exploration in new environment "greater amount of time spent investigating new location" [J:28825]
Show

Allelic Composition: Fgf3tm4b(EUCOMM)Hmgu/Fgf3tm4b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Fgf3tm4b(EUCOMM)Hmgu/Bay

 MP:0011239 abnormal skin coloration "a variation in an expected skin color or complexion that may be due to inflammation, pigment defects or other causes" [MGI:llw2]
Show

Allelic Composition: Fgf3tm4b(EUCOMM)Hmgu/Fgf3tm4b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Fgf3tm4b(EUCOMM)Hmgu/Bay

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr