ENSMUSG00000030107


Mus musculus
increasedUsp18activitydecreasedpeptidaseubiquitinhydrolaseproteaseproteinsusceptibilityspecificresponseregulationisgcountdeathbacterialinfectionenlargedinterferon-gammasecretioncirculatinglevelinterleukin-inducedccarboxyl-terminalconservedsitedomainproteolysis

Features
Gene ID: ENSMUSG00000030107
  
Biological name :Usp18
  
Synonyms : Q9WTV6 / ubiquitin specific peptidase 18 / Usp18
  
Possible biological names infered from orthology : Q3LFD5 / Q9UMW8 / ubiquitin specific peptidase 41 / USP41
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: F1
Gene start: 121245906
Gene end: 121270917
  
Corresponding Affymetrix probe sets: 10541307 (MoGene1.0st)   1418191_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000145285
Ensembl peptide - ENSMUSP00000032198
NCBI entrez gene - 24110     See in Manteia.
MGI - MGI:1344364
RefSeq - NM_011909
RefSeq Peptide - NP_036039
swissprot - A0A0N4SVX5
swissprot - Q9WTV6
Ensembl - ENSMUSG00000030107
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 usp18ENSDARG00000088078Danio rerio
 ENSGALG00000013057Gallus gallus
 USP18ENSG00000184979Homo sapiens
 USP41ENSG00000161133Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Usp47 / Q8BY87 / ubiquitin specific peptidase 47 / Q96K76*ENSMUSG0000005926326
Usp40 / Q8BWR4 / ubiquitin specific peptidase 40 / Q9NVE5*ENSMUSG0000000550124
Usp24 / B1AY13 / ubiquitin specific peptidase 24 / Q9UPU5*ENSMUSG0000002851424
Usp48 / Q3V0C5 / ubiquitin specific peptidase 48 / Q86UV5*ENSMUSG0000004341124
Usp9y / ubiquitin specific peptidase 9, Y chromosome / O00507* / ubiquitin specific peptidase 9, Y-linked*ENSMUSG0000006904424
Usp9x / ubiquitin specific peptidase 9, X chromosome / Q93008* / ubiquitin specific peptidase 9, X-linked*ENSMUSG0000003101023
Usp7 / ubiquitin specific peptidase 7 / Q93009*ENSMUSG0000002271022
Usp34 / Q6ZQ93 / ubiquitin specific peptidase 34 / Q70CQ2*ENSMUSG0000005634220


Protein motifs (from Interpro)
Interpro ID Name
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR018200  Ubiquitin specific protease, conserved site
 IPR028889  Ubiquitin specific protease domain


Gene Ontology (GO)
nitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcatabolic processcellular metabolic processresponse to chemicalresponse to stressresponse to external stimulusnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcatabolic processcellular metabolic processresponse to chemicalresponse to stressresponse to external stimulusnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcatabolic processcellular metabolic processresponse to chemicalresponse to stressresponse to external stimulusnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcatabolic processcellular metabolic processresponse to chemicalresponse to stressresponse to external stimulusnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcatabolic processcellular metabolic processresponse to chemicalresponse to stressresponse to external stimulusnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcatabolic processcellular metabolic processresponse to chemicalresponse to stressresponse to external stimulusnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcatabolic processcellular metabolic processresponse to chemicalresponse to stressresponse to external stimulusnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcatabolic processcellular metabolic processresponse to chemicalresponse to stressresponse to external stimulusnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcatabolic processcellular metabolic processresponse to chemicalresponse to stressresponse to external stimulusnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcatabolic processcellular metabolic processresponse to chemicalresponse to stressresponse to external stimulusnitrogen compoundnitrogen compound metabolic processprimary metabolicprimary metabolic processorganic substanceorganic substance metabolic processcatabolic processcatabolic processcellular metabolicellular metabolic processresponse to chemiresponse to chemicalresponse to stresresponse to stressresponse to exterresponse to external stimulus
protein bindingcatalytic activity, acting on a proteinhydrolase activityprotein bindingcatalytic activity, acting on a proteinhydrolase activityprotein bindingcatalytic activity, acting on a proteinhydrolase activityprotein bindingcatalytic activity, acting on a proteinhydrolase activityprotein bindingcatalytic activity, acting on a proteinhydrolase activityprotein bindingcatalytic activity, acting on a proteinhydrolase activityprotein bindingcatalytic activity, acting on a proteinhydrolase activityprotein bindingcatalytic activity, acting on a proteinhydrolase activityprotein bindingcatalytic activity, acting on a proteinhydrolase activityprotein bindingcatalytic activity, acting on a proteinhydrolase activityprotein bindingprotein bindingcatalytic activity, acting on a proteincatalytic activity, acting on a proteinhydrolase activityhydrolase activity
cellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellcellorganelleorganelle
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0016579 protein deubiquitination IEA
 biological_processGO:0035634 response to stilbenoid IEP
 biological_processGO:0050727 regulation of inflammatory response ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005829 cytosol ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019785 ISG15-specific protease activity ISO
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA


Pathways (from Reactome)
Pathway description
ISG15 antiviral mechanism
Ub-specific processing proteases
Regulation of IFNA signaling


Phenotype (from MGI, Zfin or HPO)
immune system phenotypehematopoietic system phenotypebehavior/neurological phenotypenervous system phenotypecardiovascular system phenotypemortality/aginghomeostasis/metabolism phenotypecellular phenotypeimmune system phenotypehematopoietic system phenotypebehavior/neurological phenotypenervous system phenotypecardiovascular system phenotypemortality/aginghomeostasis/metabolism phenotypecellular phenotypeimmune system phenotypehematopoietic system phenotypebehavior/neurological phenotypenervous system phenotypecardiovascular system phenotypemortality/aginghomeostasis/metabolism phenotypecellular phenotypeimmune system phenotypehematopoietic system phenotypebehavior/neurological phenotypenervous system phenotypecardiovascular system phenotypemortality/aginghomeostasis/metabolism phenotypecellular phenotypeimmune system phenotypehematopoietic system phenotypebehavior/neurological phenotypenervous system phenotypecardiovascular system phenotypemortality/aginghomeostasis/metabolism phenotypecellular phenotypeimmune system phenotypehematopoietic system phenotypebehavior/neurological phenotypenervous system phenotypecardiovascular system phenotypemortality/aginghomeostasis/metabolism phenotypecellular phenotypeimmune system phenotypehematopoietic system phenotypebehavior/neurological phenotypenervous system phenotypecardiovascular system phenotypemortality/aginghomeostasis/metabolism phenotypecellular phenotypeimmune system phenotypehematopoietic system phenotypebehavior/neurological phenotypenervous system phenotypecardiovascular system phenotypemortality/aginghomeostasis/metabolism phenotypecellular phenotypeimmune system phenotypehematopoietic system phenotypebehavior/neurological phenotypenervous system phenotypecardiovascular system phenotypemortality/aginghomeostasis/metabolism phenotypecellular phenotypeimmune system phenotypehematopoietic system phenotypebehavior/neurological phenotypenervous system phenotypecardiovascular system phenotypemortality/aginghomeostasis/metabolism phenotypecellular phenotypeimmune system pheimmune system phenotypehematopoietic syshematopoietic system phenotypebehavior/neurologbehavior/neurological phenotypenervous system phnervous system phenotypecardiovascular sycardiovascular system phenotypemortality/agingmortality/aginghomeostasis/metabhomeostasis/metabolism phenotypecellular phenotypcellular phenotype
IDPhenotypeDefinition Genetic BG
 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ugt8atm1Wst/Ugt8atm1Wst
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Ugt8atm1Wst/Ugt8atm1Wst
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000947 convulsive seizures "seizures characterized by uncontrolled motor activity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ugt8atm1Wst/Ugt8atm1Wst
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001394 circling "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]
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Allelic Composition: Ugt8atm1Wst/Ugt8atm1Wst
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001411 spinning "compulsive rolling of the body" [J:17123]
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Allelic Composition: Ugt8atm1Wst/Ugt8atm1Wst
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Ugt8atm1Wst/Ugt8atm1Wst
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001916 intracerebral hemorrhage "bleeding within the cerebrum" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ugt8atm1Wst/Ugt8atm1Wst
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ugt8atm1Wst/Ugt8atm1Wst
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S4/SvJae * FVB/N

Allelic Composition: Usp18ity9/Usp18tm1Dez
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0002619 abnormal lymphocyte morphology/development "anomalous structure, differentiation, or number of the white blood cells formed in the body s lymphoid tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0008535 enlarged lateral ventricles "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ugt8atm1Wst/Ugt8atm1Wst
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008536 enlarged third ventricle "increased size of the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [MESH:A08.186.211.276.840, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ugt8atm1Wst/Ugt8atm1Wst
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0008578 decreased circulating interferon-gamma level "reduction in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0008943 increased sensitivity to induced cell death "decrease in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nodaltm1.1Mku/Nodaltm2Mku,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S1/Sv * C3H * C57BL/6

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S4/SvJae * FVB/N

Allelic Composition: Usp18ity9/Usp18tm1Dez
Genetic Background: involves: 129 * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022414 Tab1 / Q8CF89 / TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 / Q15750* / TGF-beta activated kinase 1 (MAP3K7) binding protein 1*  / complex
 ENSMUSG00000022971 O35664 / Ifnar2 / interferon (alpha and beta) receptor 2 / P48551* / AP000295.1* / interferon alpha and beta receptor subunit 2*  / complex / reaction
 ENSMUSG00000028284 Map3k7 / Q62073 / Mitogen-activated protein kinase kinase kinase 7 / O43318*  / complex






 

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