ENSMUSG00000030220


Mus musculus

Features
Gene ID: ENSMUSG00000030220
  
Biological name :Arhgdib
  
Synonyms : Arhgdib / Q61599 / Rho GDP-dissociation inhibitor 2
  
Possible biological names infered from orthology : P52566 / Rho GDP dissociation inhibitor beta
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: G1
Gene start: 136923655
Gene end: 136941899
  
Corresponding Affymetrix probe sets: 10548892 (MoGene1.0st)   1426454_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000032344
Ensembl peptide - ENSMUSP00000107523
Ensembl peptide - ENSMUSP00000120047
Ensembl peptide - ENSMUSP00000145103
Ensembl peptide - ENSMUSP00000107522
NCBI entrez gene - 11857     See in Manteia.
MGI - MGI:101940
RefSeq - XM_006505404
RefSeq - NM_001301301
RefSeq - NM_001301303
RefSeq - NM_001301305
RefSeq - NM_001301308
RefSeq - NM_001301309
RefSeq - NM_007486
RefSeq Peptide - NP_001288238
RefSeq Peptide - NP_031512
RefSeq Peptide - NP_001288232
RefSeq Peptide - NP_001288230
RefSeq Peptide - NP_001288234
RefSeq Peptide - NP_001288237
swissprot - Q61599
swissprot - D3YWL7
swissprot - A0A0N4SVH4
Ensembl - ENSMUSG00000030220
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arhgdigENSDARG00000004034Danio rerio
 ARHGDIBENSGALG00000011738Gallus gallus
 P52566ENSG00000111348Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q99PT1 / Arhgdia / Rho GDP-dissociation inhibitor 1 / P52565* / Rho GDP dissociation inhibitor alpha*ENSMUSG0000002513267
Q62160 / Arhgdig / Rho GDP-dissociation inhibitor 3 / Q99819* / Rho GDP dissociation inhibitor gamma*ENSMUSG0000007343357


Protein motifs (from Interpro)
Interpro ID Name
 IPR000406  Rho protein GDP-dissociation inhibitor
 IPR014756  Immunoglobulin E-set
 IPR024792  Rho GDP-dissociation inhibitor domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0035023 regulation of Rho protein signal transduction ISS
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0050790 regulation of catalytic activity IEA
 biological_processGO:0071461 cellular response to redox state IEA
 biological_processGO:1901164 negative regulation of trophoblast cell migration ISO
 biological_processGO:2000249 regulation of actin cytoskeleton reorganization ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0003924 GTPase activity ISO
 molecular_functionGO:0005094 Rho GDP-dissociation inhibitor activity IEA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0048365 Rac GTPase binding ISS


Pathways (from Reactome)
Pathway description
Rho GTPase cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000217 abnormal white blood cell count "anomalies in the number of leukocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Nectin1tm1Mjd/Nectin1tm1Mjd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
Show

Allelic Composition: Arhgdiatm1Ytk/Arhgdiatm1Ytk,Arhgdibtm1Miyo/Arhgdibtm1Miyo
Genetic Background: involves: 129S/SvEv

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Nectin1tm1Mjd/Nectin1tm1Mjd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Arhgdiatm1Ytk/Arhgdiatm1Ytk,Arhgdibtm1Miyo/Arhgdibtm1Miyo
Genetic Background: involves: 129S/SvEv

 MP:0001940 testicular hypoplasia "decreased cell number in the testicles" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nectin1tm1Mjd/Nectin1tm1Mjd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002344 abnormal lymph node B cell domain "anomaly in the lymph node cortex in which B lymphocytes reside" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Arhgdiatm1Ytk/Arhgdiatm1Ytk,Arhgdibtm1Miyo/Arhgdibtm1Miyo
Genetic Background: involves: 129S/SvEv

 MP:0002375 abnormal thymus medulla morphology "anomalous structure or development of the inner area of thymus lobules" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Arhgdiatm1Ytk/Arhgdiatm1Ytk,Arhgdibtm1Miyo/Arhgdibtm1Miyo
Genetic Background: involves: 129S/SvEv

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nectin1tm1Mjd/Nectin1tm1Mjd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nectin1tm1Mjd/Nectin1tm1Mjd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Arhgdiatm1Ytk/Arhgdiatm1Ytk,Arhgdibtm1Miyo/Arhgdibtm1Miyo
Genetic Background: involves: 129S/SvEv

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nectin1tm1Mjd/Nectin1tm1Mjd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nectin1tm1Mjd/Nectin1tm1Mjd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Arhgdiatm1Ytk/Arhgdiatm1Ytk,Arhgdibtm1Miyo/Arhgdibtm1Miyo
Genetic Background: involves: 129S/SvEv

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Arhgdiatm1Ytk/Arhgdiatm1Ytk,Arhgdibtm1Miyo/Arhgdibtm1Miyo
Genetic Background: involves: 129S/SvEv

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Arhgdiatm1Ytk/Arhgdiatm1Ytk,Arhgdibtm1Miyo/Arhgdibtm1Miyo
Genetic Background: involves: 129S/SvEv

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hfetm1.1Nca/Hfetm1.1Nca
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Arhgdiatm1Ytk/Arhgdiatm1Ytk,Arhgdibtm1Miyo/Arhgdibtm1Miyo
Genetic Background: involves: 129S/SvEv

 MP:0005232 abnormal mesenteric lymph node morphology "anomalous structure, development, or number of the lymph nodes located in the mesentary, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Arhgdiatm1Ytk/Arhgdiatm1Ytk,Arhgdibtm1Miyo/Arhgdibtm1Miyo
Genetic Background: involves: 129S/SvEv

 MP:0008082 increased single-positive T cell number "greater number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Arhgdiatm1Ytk/Arhgdiatm1Ytk,Arhgdibtm1Miyo/Arhgdibtm1Miyo
Genetic Background: involves: 129S/SvEv

 MP:0008174 decreased follicular B cell number "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Arhgdiatm1Ytk/Arhgdiatm1Ytk,Arhgdibtm1Miyo/Arhgdibtm1Miyo
Genetic Background: involves: 129S/SvEv

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
Show

Allelic Composition: Arhgdiatm1Ytk/Arhgdiatm1Ytk,Arhgdibtm1Miyo/Arhgdibtm1Miyo
Genetic Background: involves: 129S/SvEv

 MP:0008190 decreased transitional stage B cell number "reduced number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Arhgdiatm1Ytk/Arhgdiatm1Ytk,Arhgdibtm1Miyo/Arhgdibtm1Miyo
Genetic Background: involves: 129S/SvEv

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Arhgdiatm1Ytk/Arhgdiatm1Ytk,Arhgdibtm1Miyo/Arhgdibtm1Miyo
Genetic Background: involves: 129S/SvEv

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
Show

Allelic Composition: Arhgdiatm1Ytk/Arhgdiatm1Ytk,Arhgdibtm1Miyo/Arhgdibtm1Miyo
Genetic Background: involves: 129S/SvEv

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Arhgdiatm1Ytk/Arhgdiatm1Ytk,Arhgdibtm1Miyo/Arhgdibtm1Miyo
Genetic Background: involves: 129S/SvEv

 MP:0008470 abnormal spleen B cell follicle morphology "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]
Show

Allelic Composition: Arhgdiatm1Ytk/Arhgdiatm1Ytk,Arhgdibtm1Miyo/Arhgdibtm1Miyo
Genetic Background: involves: 129S/SvEv

 MP:0008626 increased circulating interleukin-5 level "increase in the amount in the blood of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
Show

Allelic Composition: Arhgdiatm1Ytk/Arhgdiatm1Ytk,Arhgdibtm1Miyo/Arhgdibtm1Miyo
Genetic Background: involves: 129S/SvEv

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Arhgdiatm1Ytk/Arhgdiatm1Ytk,Arhgdibtm1Miyo/Arhgdibtm1Miyo
Genetic Background: involves: 129S/SvEv

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Arhgdiatm1Ytk/Arhgdiatm1Ytk,Arhgdibtm1Miyo/Arhgdibtm1Miyo
Genetic Background: involves: 129S/SvEv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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