ENSMUSG00000030283


Mus musculus

Features
Gene ID: ENSMUSG00000030283
  
Biological name :St8sia1
  
Synonyms : Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase / Q64687 / St8sia1
  
Possible biological names infered from orthology : Q92185 / ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: G3
Gene start: 142821545
Gene end: 142964452
  
Corresponding Affymetrix probe sets: 10549162 (MoGene1.0st)   1419694_at (Mouse Genome 430 2.0 Array)   1419695_at (Mouse Genome 430 2.0 Array)   1455695_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000032421
Ensembl peptide - ENSMUSP00000145148
NCBI entrez gene - 20449     See in Manteia.
MGI - MGI:106011
RefSeq - XM_017321472
RefSeq - NM_011374
RefSeq - XM_011241574
RefSeq - XM_011241575
RefSeq - XM_011241576
RefSeq - XM_006506928
RefSeq - XM_006506929
RefSeq - XM_006506930
RefSeq Peptide - NP_035504
swissprot - Q64687
swissprot - A0A0N4SVL1
Ensembl - ENSMUSG00000030283
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 st8sia1ENSDARG00000098221Danio rerio
 ST8SIA1ENSGALG00000013211Gallus gallus
 Q92185ENSG00000111728Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P70126 / St8sia5 / Alpha-2,8-sialyltransferase 8E / O15466* / ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5*ENSMUSG0000002542538
Q8K4T1 / St8sia6 / ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 / P61647*ENSMUSG0000000341836
O35696 / St8sia2 / Alpha-2,8-sialyltransferase 8B / Q92186* / ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2*ENSMUSG0000002578929
Q64689 / St8sia3 / Sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase / O43173* / ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3*ENSMUSG0000005681229
Q64692 / St8sia4 / ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 / Q92187*ENSMUSG0000004071027


Protein motifs (from Interpro)
Interpro ID Name
 IPR001675  Glycosyl transferase family 29
 IPR012163  Sialyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006486 protein glycosylation IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006665 sphingolipid metabolic process IEA
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0034605 cellular response to heat IDA
 biological_processGO:0097503 sialylation IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IEA
 molecular_functionGO:0008373 sialyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA


Pathways (from Reactome)
Pathway description
Sialic acid metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Otcspf-ash/Otc+
Genetic Background: involves: C57BL/6

 MP:0001496 audiogenic seizures "a reflex seizure triggered by loud noises" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Otcspf-ash/Otc+
Genetic Background: involves: C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Otcspf-ash/Otc+
Genetic Background: involves: C57BL/6

 MP:0001951 abnormal breathing "irregular or atypical breathing pattern " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]
Show

Allelic Composition: B4galnt1tm1Rlp/B4galnt1tm1Rlp,St8sia1tm1Rlp/St8sia1tm1Rlp
Genetic Background: involves: 129S6/SvEvTac

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Otcspf-ash/Otc+
Genetic Background: involves: C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Otcspf-ash/Otc+
Genetic Background: involves: C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Otcspf-ash/Otc+
Genetic Background: involves: C57BL/6

 MP:0003997 tonic-clonic seizures "increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: B4galnt1tm1Rlp/B4galnt1tm1Rlp,St8sia1tm1Rlp/St8sia1tm1Rlp
Genetic Background: involves: 129S6/SvEvTac

 MP:0004858 abnormal nervous system regeneration "changes in the ability or inability of healthy nervous system tissue to regenerate following injury or disease" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Sema3atm1Mcf/Sema3atm1Mcf
Genetic Background: involves: 129S4/SvJae

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sema3atm1Mcf/Sema3atm1Mcf
Genetic Background: involves: 129S4/SvJae

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sema3atm1Mcf/Sema3atm1Mcf
Genetic Background: involves: 129S4/SvJae

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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