ENSMUSG00000030382


Mus musculus

Features
Gene ID: ENSMUSG00000030382
  
Biological name :Slc27a5
  
Synonyms : Bile acyl-CoA synthetase / Q4LDG0 / Slc27a5
  
Possible biological names infered from orthology : Q9Y2P5 / solute carrier family 27 member 5
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: A1
Gene start: 12988346
Gene end: 12998192
  
Corresponding Affymetrix probe sets: 10560045 (MoGene1.0st)   1449112_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000112495
Ensembl peptide - ENSMUSP00000117208
Ensembl peptide - ENSMUSP00000032539
NCBI entrez gene - 26459     See in Manteia.
MGI - MGI:1347100
RefSeq - NM_009512
RefSeq Peptide - NP_033538
swissprot - Q4LDG0
swissprot - E9PXV4
swissprot - F6YDR6
Ensembl - ENSMUSG00000030382
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q9Y2P5ENSG00000083807Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Slc27a6 / solute carrier family 27 member 6 / Q9Y2P4*ENSMUSG0000002460039
O35488 / Slc27a2 / Very long-chain acyl-CoA synthetase / O14975* / solute carrier family 27 member 2*ENSMUSG0000002735939
Slc27a3 / solute carrier family 27 (fatty acid transporter), member 3 / Q5K4L6* / solute carrier family 27 member 3*ENSMUSG0000002793238
Q60714 / Slc27a1 / solute carrier family 27 (fatty acid transporter), member 1 / Q6PCB7* / solute carrier family 27 member 1*ENSMUSG0000003180835
Q91VE0 / Slc27a4 / Long-chain fatty acid transport protein 4 / Q6P1M0* / solute carrier family 27 member 4*ENSMUSG0000005931634


Protein motifs (from Interpro)
Interpro ID Name
 IPR000873  AMP-dependent synthetase/ligase
 IPR020845  AMP-binding, conserved site
 IPR025110  AMP-binding enzyme, C-terminal domain
 IPR030302  Fatty acid transport protein 5


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000038 very long-chain fatty acid metabolic process IEA
 biological_processGO:0001676 long-chain fatty acid metabolic process IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006642 triglyceride mobilization IMP
 biological_processGO:0006699 bile acid biosynthetic process IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0008206 bile acid metabolic process IEA
 biological_processGO:0015908 fatty acid transport IEA
 biological_processGO:0015911 plasma membrane long-chain fatty acid transport IMP
 biological_processGO:0046951 ketone body biosynthetic process IMP
 cellular_componentGO:0005783 endoplasmic reticulum TAS
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0009925 basal plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030176 integral component of endoplasmic reticulum membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004467 long-chain fatty acid-CoA ligase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0015245 fatty acid transmembrane transporter activity IEA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0031957 very long-chain fatty acid-CoA ligase activity IEA
 molecular_functionGO:0047747 cholate-CoA ligase activity IEA


Pathways (from Reactome)
Pathway description
Recycling of bile acids and salts
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Synthesis of bile acids and bile salts via 24-hydroxycholesterol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Atf4tm1Jml/Atf4tm1Jml
Genetic Background: involves: 129X1/SvJ

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Atf4tm1Jml/Atf4tm1Jml
Genetic Background: involves: 129X1/SvJ

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Atf4tm1Jml/Atf4tm1Jml,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Atf4tm1Jml/Atf4tm1Jml
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Slc27a5tm1Asta/Slc27a5tm1Asta
Genetic Background: involves: 129/Sv

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Atf4tm1Jml/Atf4tm1Jml
Genetic Background: involves: 129X1/SvJ

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Atf4tm1Jml/Atf4tm1Jml
Genetic Background: involves: 129X1/SvJ

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Atf4tm1Jml/Atf4tm1Jml
Genetic Background: involves: 129X1/SvJ

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Atf4tm1Jml/Atf4tm1Jml
Genetic Background: involves: 129X1/SvJ

 MP:0003458 decreased circulating ketone body level "less than the normal amount of acetoacetate, 3-hydroxybutyrate and acteone in the blood; produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Atf4tm1Jml/Atf4tm1Jml
Genetic Background: involves: 129X1/SvJ

 MP:0004773 abnormal bile composition "any alteration in the chemical make up of the greenish-yellow fluid secreted by the liver; normally contains bile acids and salts such as sodium glycocholate and sodium taurocholate as well as cholesterol, biliverdin and bilirubin, mucus, fat, lecithin, and cells and cellular debris" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc27a5tm1Asta/Slc27a5tm1Asta
Genetic Background: involves: 129/Sv

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Atf4tm1Jml/Atf4tm1Jml
Genetic Background: involves: 129X1/SvJ

 MP:0005282 decreased fatty acid level "less than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Atf4tm1Jml/Atf4tm1Jml
Genetic Background: involves: 129X1/SvJ

 MP:0005285 decreased unsaturated fatty acid level "less than normal non-circulating level of organic, monobasic acids derived from hydrocarbons in which the carbon chain has one or more double or triple carbon-carbon bonds " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Atf4tm1Jml/Atf4tm1Jml
Genetic Background: involves: 129X1/SvJ

 MP:0005286 decreased saturated fatty acid level "less than normal non-circulating level of organic, monobasic acids derived from hydrocarbons in which the carbon chain contains only single carbon-carbon bonds " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Atf4tm1Jml/Atf4tm1Jml
Genetic Background: involves: 129X1/SvJ

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Slc27a5tm1Asta/Slc27a5tm1Asta
Genetic Background: involves: 129/Sv

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Slc27a5tm1Asta/Slc27a5tm1Asta
Genetic Background: involves: 129/Sv

 MP:0005533 increased body temperature "greater than the level of heat natural to a living being" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Slc27a5tm1Asta/Slc27a5tm1Asta
Genetic Background: involves: 129/Sv

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Atf4tm1Jml/Atf4tm1Jml
Genetic Background: involves: 129X1/SvJ

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Slc27a5tm1Asta/Slc27a5tm1Asta
Genetic Background: involves: 129/Sv

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Slc27a5tm1Asta/Slc27a5tm1Asta
Genetic Background: involves: 129/Sv

 MP:0009289 decreased epididymal fat pad weight 
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Allelic Composition: Slc27a5tm1Asta/Slc27a5tm1Asta
Genetic Background: involves: 129/Sv

 MP:0009305 decreased retroperitoneal fat pad weight 
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Allelic Composition: Slc27a5tm1Asta/Slc27a5tm1Asta
Genetic Background: involves: 129/Sv

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atf4tm1Jml/Atf4tm1Jml
Genetic Background: involves: 129X1/SvJ

 MP:0010026 decreased liver cholesterol level "less than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atf4tm1Jml/Atf4tm1Jml
Genetic Background: involves: 129X1/SvJ

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Slc27a5tm1Asta/Slc27a5tm1Asta
Genetic Background: involves: 129/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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