ENSMUSG00000030510


Mus musculus

Features
Gene ID: ENSMUSG00000030510
  
Biological name :Cers3
  
Synonyms : Ceramide synthase 3 / Cers3 / Q1A3B0
  
Possible biological names infered from orthology : Q8IU89
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: C
Gene start: 66743504
Gene end: 66823691
  
Corresponding Affymetrix probe sets: 10554034 (MoGene1.0st)   1444740_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000069238
Ensembl peptide - ENSMUSP00000146745
NCBI entrez gene - 545975     See in Manteia.
MGI - MGI:2681008
RefSeq - XM_011250877
RefSeq - NM_001164201
RefSeq - XM_006541001
RefSeq - XM_006541002
RefSeq Peptide - NP_001157673
swissprot - Q1A3B0
Ensembl - ENSMUSG00000030510
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cers3aENSDARG00000078541Danio rerio
 cers3bENSDARG00000036337Danio rerio
 CERS3ENSGALG00000014624Gallus gallus
 CERS3ENSG00000154227Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cers2 / Q924Z4 / Ceramide synthase 2 / Q96G23*ENSMUSG0000001571446
Cers4 / Q9D6J1 / Ceramide synthase 4 / Q9HA82*ENSMUSG0000000820637
Cers5 / Q9D6K9 / Ceramide synthase 5 / Q8N5B7*ENSMUSG0000002302137
Cers6 / Q8C172 / Ceramide synthase 6 / Q6ZMG9*ENSMUSG0000002703537


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR006634  TRAM/LAG1/CLN8 homology domain
 IPR009057  Homeobox-like domain superfamily
 IPR016439  Sphingosine N-acyltransferase Lag1/Lac1-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0030148 sphingolipid biosynthetic process IDA
 biological_processGO:0030216 keratinocyte differentiation ISO
 biological_processGO:0046513 ceramide biosynthetic process IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005783 endoplasmic reticulum IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0050291 sphingosine N-acyltransferase activity IDA


Pathways (from Reactome)
Pathway description
Sphingolipid de novo biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001190 reddish skin "skin has a more intense ruddy appearance than normal, often due to capillary congestion" [J:65038]
Show

Allelic Composition: MitfMi/MitfMi-J
Genetic Background: involves: C3HeB/Fe * C57BL/6J * C57BL/10J

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
Show

Allelic Composition: MitfMi/MitfMi-J
Genetic Background: involves: C3HeB/Fe * C57BL/6J * C57BL/10J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: MitfMi/MitfMi-J
Genetic Background: involves: C3HeB/Fe * C57BL/6J * C57BL/10J

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
Show

Allelic Composition: MitfMi/MitfMi-J
Genetic Background: involves: C3HeB/Fe * C57BL/6J * C57BL/10J

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: MitfMi/MitfMi-J
Genetic Background: involves: C3HeB/Fe * C57BL/6J * C57BL/10J

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
Show

Allelic Composition: MitfMi/MitfMi-J
Genetic Background: involves: C3HeB/Fe * C57BL/6J * C57BL/10J

 MP:0003453 abnormal keratinocyte physiology "atypical function of the cells of the epidermis that produce keratin" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:94860]
Show

Allelic Composition: MitfMi/MitfMi-J
Genetic Background: involves: C3HeB/Fe * C57BL/6J * C57BL/10J

 MP:0003941 abnormal skin development "anomaly in the formation of of the membranous protective covering of the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: MitfMi/MitfMi-J
Genetic Background: involves: C3HeB/Fe * C57BL/6J * C57BL/10J

 MP:0005399 increased susceptibility to fungal infection "greater likelihood that an organism will develop ill effects from infection by a yeast or mold, or from components of, or toxins produced by, these organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: MitfMi/MitfMi-J
Genetic Background: involves: C3HeB/Fe * C57BL/6J * C57BL/10J

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: MitfMi/MitfMi-J
Genetic Background: involves: C3HeB/Fe * C57BL/6J * C57BL/10J

 MP:0009596 abnormal stratum corneum lipid matrix formation "altered lipid composition or intercellular lipid matrix assembly in the stratum corneum, usually resulting in loss of epidermal barrier function; normally, the intercorneocyte lipid matrix consists of a complex lipid mixture of ceramides, cholesterol and long-chain saturated fatty acids that self-assembles into an ordered multilayer structure known as lipid lamellae" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: MitfMi/MitfMi-J
Genetic Background: involves: C3HeB/Fe * C57BL/6J * C57BL/10J

 MP:0009597 impaired stratum corneum desquamation "dysregulated shedding of the outermost layer of corneocytes, affecting the integrity and thickness of the stratum corneum; may result in xerotic and ichthyotic conditions" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: MitfMi/MitfMi-J
Genetic Background: involves: C3HeB/Fe * C57BL/6J * C57BL/10J

 MP:0009608 abnormal lamellar body morphology "any structural anomaly of a membrane-bounded organelle, specialized for the storage and secretion various substances (surfactant phospholipids, glycoproteins and acid phosphates) which are arranged in the form of tightly packed, concentric, membrane sheets or lamellae" [GO:0042599]
Show

Allelic Composition: MitfMi/MitfMi-J
Genetic Background: involves: C3HeB/Fe * C57BL/6J * C57BL/10J

 MP:0009931 abnormal skin appearance "skin that looks different from the usual state" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: MitfMi/MitfMi-J
Genetic Background: involves: C3HeB/Fe * C57BL/6J * C57BL/10J

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: MitfMi/MitfMi-J
Genetic Background: involves: C3HeB/Fe * C57BL/6J * C57BL/10J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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