ENSMUSG00000030549


Mus musculus

Features
Gene ID: ENSMUSG00000030549
  
Biological name :Rhcg
  
Synonyms : Ammonium transporter Rh type C / Q9QXP0 / Rhcg
  
Possible biological names infered from orthology : Q9UBD6 / Rh family C glycoprotein
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: D2
Gene start: 79593363
Gene end: 79617657
  
Corresponding Affymetrix probe sets: 10564762 (MoGene1.0st)   1417362_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000032766
Ensembl peptide - ENSMUSP00000134005
Ensembl peptide - ENSMUSP00000134230
NCBI entrez gene - 56315     See in Manteia.
MGI - MGI:1888517
RefSeq - XM_006541004
RefSeq - XM_011250878
RefSeq - NM_019799
RefSeq Peptide - NP_062773
swissprot - Q9QXP0
swissprot - G3UYU7
swissprot - G3UYA4
Ensembl - ENSMUSG00000030549
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rhcgaENSDARG00000003203Danio rerio
 rhcgbENSDARG00000100265Danio rerio
 rhcgl1ENSDARG00000007080Danio rerio
 RHCGENSGALG00000006635Gallus gallus
 RHCGENSG00000140519Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rhbg / Q8BUX5 / Ammonium transporter Rh type B / Q9H310* / Rh family B glycoprotein (gene/pseudogene)*ENSMUSG0000010444549
Gm38392 / RHBG* / Q9H310* / Rh family B glycoprotein (gene/pseudogene)*ENSMUSG0000010376645
Rhag / Q9QUT0 / Ammonium transporter Rh type A / Q02094* / Rh associated glycoprotein*ENSMUSG0000002392642
Rhd / RHCE* / P18577* / Q02161* / Rh blood group D antigen* / Rh blood group CcEe antigens*ENSMUSG0000002882526


Protein motifs (from Interpro)
Interpro ID Name
 IPR002229  Blood group Rhesus C/E/D polypeptide
 IPR024041  Ammonium transporter AmtB-like domain
 IPR029020  Ammonium/urea transporter


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006873 cellular ion homeostasis IEA
 biological_processGO:0006885 regulation of pH IMP
 biological_processGO:0015695 organic cation transport IBA
 biological_processGO:0015696 ammonium transport ISO
 biological_processGO:0070634 transepithelial ammonium transport IEA
 biological_processGO:0072488 ammonium transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 molecular_functionGO:0008519 ammonium transmembrane transporter activity ISO
 molecular_functionGO:0030506 ankyrin binding IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Rhesus glycoproteins mediate ammonium transport.


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000525 renal tubular acidosis "a clinical syndrome characterized by the inability to acidify urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19268]
Show

Allelic Composition: Tyrc-20FATw/Tyrc
Genetic Background: involves: 101/Rl * C3H/Rl

Allelic Composition: Rhcgtm1Ibmm/Rhcgtm1Ibmm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Tyrc-20FATw/Tyrc
Genetic Background: involves: 101/Rl * C3H/Rl

Allelic Composition: Rhcgtm1Ibmm/Rhcgtm1Ibmm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Tyrc-20FATw/Tyrc
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0002631 abnormal epididymis morphology "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tyrc-20FATw/Tyrc
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0003014 abnormal kidney medulla morphology "anomalous structure of the inner portion of the kidney consisting of the renal pyramids" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:88636, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rhcgtm1Tigm/Rhcg+
Genetic Background: involves: 129S/SvEvBrd * C57BL/6

 MP:0003031 acidosis "a pathological state characterized by an increase in the hydrogen ion concentration of arterial blood; caused by an decrease in the concentration of alkaline compounds, or by a increase in the concentration of acidic compounds or carbon dioxide to the body fluids" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tyrc-20FATw/Tyrc
Genetic Background: involves: 101/Rl * C3H/Rl

Allelic Composition: Rhcgtm1Tigm/Rhcg+
Genetic Background: involves: 129S/SvEvBrd * C57BL/6

Allelic Composition: Rhcgtm1Tigm/Rhcgtm1Tigm
Genetic Background: involves: 129S/SvEvBrd * C57BL/6

 MP:0004754 abnormal kidney collecting duct "any structural anomaly of the duct that drains fluid from the nephron and either allows bodily reabsorbtion of water or allows the fluid to drain to the bladder via the ureter; the collecting duct system also maintains acid-base homeostasis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rhcgtm1Tigm/Rhcg+
Genetic Background: involves: 129S/SvEvBrd * C57BL/6

Allelic Composition: Rhcgtm1Tigm/Rhcgtm1Tigm
Genetic Background: involves: 129S/SvEvBrd * C57BL/6

 MP:0005628 decreased circulating potassium level "less than the normal concentration in the blood of this alkaline metallic element, the most abundant intracellular ion; anomalies in the extracellular (circulating) concentration have important implications for the function of excitable tissues, such as nerve and muscle" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Tyrc-20FATw/Tyrc
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0009349 increased urine pH "increased urine alkalinity" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tyrc-20FATw/Tyrc
Genetic Background: involves: 101/Rl * C3H/Rl

Allelic Composition: Rhcgtm1Tigm/Rhcg+
Genetic Background: involves: 129S/SvEvBrd * C57BL/6

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rhcgtm1Tigm/Rhcgtm1Tigm
Genetic Background: involves: 129S/SvEvBrd * C57BL/6

 MP:0011736 decreased urine ammonia level "a reduced amount of ammonia in the urine compared to the normal state" [MGI:anna]
Show

Allelic Composition: Tyrc-20FATw/Tyrc
Genetic Background: involves: 101/Rl * C3H/Rl

Allelic Composition: Rhcgtm1Tigm/Rhcgtm1Tigm
Genetic Background: involves: 129S/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr