ENSMUSG00000030589


Mus musculus

Features
Gene ID: ENSMUSG00000030589
  
Biological name :Rasgrp4
  
Synonyms : Q8BTM9 / Rasgrp4 / RAS guanyl releasing protein 4
  
Possible biological names infered from orthology : Q8TDF6
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: B1
Gene start: 29134851
Gene end: 29153961
  
Corresponding Affymetrix probe sets: 10551696 (MoGene1.0st)   1425380_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000124183
Ensembl peptide - ENSMUSP00000145352
Ensembl peptide - ENSMUSP00000145259
Ensembl peptide - ENSMUSP00000145186
Ensembl peptide - ENSMUSP00000144774
Ensembl peptide - ENSMUSP00000144753
Ensembl peptide - ENSMUSP00000125544
Ensembl peptide - ENSMUSP00000125137
Ensembl peptide - ENSMUSP00000124908
Ensembl peptide - ENSMUSP00000032811
Ensembl peptide - ENSMUSP00000092200
Ensembl peptide - ENSMUSP00000123718
NCBI entrez gene - 233046     See in Manteia.
MGI - MGI:2386851
RefSeq - XM_017322165
RefSeq - NM_001174155
RefSeq - NM_145149
RefSeq - XM_011250525
RefSeq - XM_017322159
RefSeq - XM_017322160
RefSeq - XM_017322161
RefSeq - XM_017322162
RefSeq - XM_017322163
RefSeq - XM_017322164
RefSeq Peptide - NP_660131
RefSeq Peptide - NP_001167626
swissprot - A0A0N4SW33
swissprot - A0A0N4SVV6
swissprot - A0A0N4SVP1
swissprot - A0A0N4SUQ3
swissprot - A0A0N4SUN7
swissprot - F7BK25
swissprot - E0CZ06
swissprot - E9QKB7
swissprot - Q8BTM9
swissprot - E0CX54
Ensembl - ENSMUSG00000030589
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rasgrp4ENSDARG00000061796Danio rerio
 Q8TDF6ENSG00000171777Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9Z1S3 / Rasgrp1 / RAS guanyl releasing protein 1 / O95267*ENSMUSG0000002734745
Rasgrp3 / RAS, guanyl releasing protein 3 / Q8IV61*ENSMUSG0000007104238
Q9QUG9 / Rasgrp2 / RAS, guanyl releasing protein 2 / Q7LDG7*ENSMUSG0000003294637
Q8CHG7 / Rapgef2 / Rap guanine nucleotide exchange factor 2 / Q9Y4G8*ENSMUSG0000006223218
Rapgef6 / Rap guanine nucleotide exchange factor (GEF) 6 / Q8TEU7* / AC008695.1* / Rap guanine nucleotide exchange factor 6*ENSMUSG0000003753317
Q8VCC8 / Rapgef3 / Mus musculus Rap guanine nucleotide exchange factor (GEF) 3 (Rapgef3), transcript variant 4, mRNA. / O95398* / Rap guanine nucleotide exchange factor 3*ENSMUSG0000002246916
Q9EQZ6 / Rapgef4 / Rap guanine nucleotide exchange factor (GEF) 4 / Q8WZA2* / Rap guanine nucleotide exchange factor 4*ENSMUSG0000004904414
Q68EF8 / Rapgefl1 / Rap guanine nucleotide exchange factor-like 1 / Q9UHV5*ENSMUSG0000003802013
Q8C0Q9 / Rapgef5 / Rap guanine nucleotide exchange factor 5 / Q92565*ENSMUSG0000004199212
Q9D300 / Rasgef1c / Ras-GEF domain-containing family member 1C / Q8N431* / RasGEF domain family member 1C*ENSMUSG0000002037411
Rasgef1a / RasGEF domain family, member 1A / Q8N9B8*ENSMUSG0000003013411
Q8JZL7 / Rasgef1b / Ras-GEF domain-containing family member 1B / Q0VAM2* / RasGEF domain family member 1B*ENSMUSG0000008980911


Protein motifs (from Interpro)
Interpro ID Name
 IPR000651  Ras-like guanine nucleotide exchange factor, N-terminal
 IPR001895  Ras guanine-nucleotide exchange factors catalytic domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR011992  EF-hand domain pair
 IPR020454  Diacylglycerol/phorbol-ester binding
 IPR023578  Ras guanine nucleotide exchange factor domain superfamily
 IPR036964  Ras guanine-nucleotide exchange factor catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0008283 cell proliferation ISS
 biological_processGO:0009991 response to extracellular stimulus ISO
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0046579 positive regulation of Ras protein signal transduction ISS
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:1904628 cellular response to phorbol 13-acetate 12-myristate ISO
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane ISO
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity ISS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
RAF/MAP kinase cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptpn12tm1b(NCOM)Mfgc/Ptpn12tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Ptpn12tm1b(NCOM)Mfgc/Tcp

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ifnar1tm1Agt/Ifnar1tm1Agt,Myd88tm1Aki/Myd88+
Genetic Background: B6.129-Myd88tm1Aki Ifnar1tm1Agt

Allelic Composition: Rasgrp4tm1d(KOMP)Lste/Rasgrp4tm1d(KOMP)Lste
Genetic Background: involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6

 MP:0003436 resistance to induced arthritis "less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]
Show

Allelic Composition: Tmem100tm1.1Ysai/Tmem100tm2.1Ysai,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0005103 abnormal retinal pigmentation "anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptpn12tm1b(NCOM)Mfgc/Ptpn12tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Ptpn12tm1b(NCOM)Mfgc/Tcp

 MP:0008539 decreased susceptibility to induced colitis "decreased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tmem100tm1.1Ysai/Tmem100tm2.1Ysai,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0008720 impaired neutrophil migration "defect in the ability of neutrophils to move along a chemotactic gradient" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ifnar1tm1Agt/Ifnar1tm1Agt,Myd88tm1Aki/Myd88+
Genetic Background: B6.129-Myd88tm1Aki Ifnar1tm1Agt

Allelic Composition: Rasgrp4tm1d(KOMP)Lste/Rasgrp4tm1d(KOMP)Lste
Genetic Background: involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr