ENSMUSG00000030745


Mus musculus

Features
Gene ID: ENSMUSG00000030745
  
Biological name :Il21r
  
Synonyms : Il21r / Interleukin-21 receptor / Q9JHX3
  
Possible biological names infered from orthology : Q9HBE5
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: F3
Gene start: 125603429
Gene end: 125633570
  
Corresponding Affymetrix probe sets: 10557342 (MoGene1.0st)   1450456_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033000
Ensembl peptide - ENSMUSP00000145772
Ensembl peptide - ENSMUSP00000145966
NCBI entrez gene - 60504     See in Manteia.
MGI - MGI:1890475
RefSeq - XM_006508098
RefSeq - NM_021887
RefSeq - XM_006508097
RefSeq Peptide - NP_068687
swissprot - Q3TAI3
swissprot - Q6PEU8
swissprot - Q9JHX3
swissprot - A0A0U1RP02
Ensembl - ENSMUSG00000030745
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 il21r.1ENSDARG00000069961Danio rerio
 il21r.2ENSDARG00000078649Danio rerio
 IL21RENSGALG00000006318Gallus gallus
 IL21RENSG00000103522Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003531  Short hematopoietin receptor, family 1, conserved site
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity ISS
 molecular_functionGO:0004896 cytokine receptor activity ISS
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Interleukin-21 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000334 decreased granulocyte number "fewer than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Srebf1tm2Jdh/Srebf1tm2Jdh
Genetic Background: involves: 129S/SvEvBrd * C57BL/6

 MP:0000685 abnormal immune system morphology "morphological anomalies in the organs or cells associated with the development and formation of lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Srebf1tm2Jdh/Srebf1tm2Jdh
Genetic Background: involves: 129S/SvEvBrd * C57BL/6

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Itktm1Lex/Itktm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Srebf1tm2Jdh/Srebf1tm2Jdh
Genetic Background: involves: 129S/SvEvBrd * C57BL/6

 MP:0001793 altered susceptibility to infection "a change in the likelihood that an organism will develop ill effects from a pathogenic invasion or from components of or toxins produced by pathogens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il21rtm1Wjl/Il21rtm1Wjl,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129 * C57BL/6

 MP:0001807 decreased IgA "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Srebf1tm2Jdh/Srebf1tm2Jdh
Genetic Background: involves: 129S/SvEvBrd * C57BL/6

Allelic Composition: Il21rtm1Kopf/Il21rtm1Kopf
Genetic Background: B6.129-Il21rtm1Kopf

Allelic Composition: Il21rtm1Wjl/Il21rtm1Wjl,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129 * C57BL/6

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cd81tm1Geha/Cd81tm1Geha
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Il21rtm1Day/Il21rtm1Day
Genetic Background: involves: BALB/c * C57BL/6

 MP:0002442 abnormal leukocyte physiology "abnormal function of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Srebf1tm2Jdh/Srebf1tm2Jdh
Genetic Background: involves: 129S/SvEvBrd * C57BL/6

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd81tm1Geha/Cd81tm1Geha
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002490 abnormal circulating immunoglobulin concentration "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Srebf1tm2Jdh/Srebf1tm2Jdh
Genetic Background: involves: 129S/SvEvBrd * C57BL/6

Allelic Composition: Il21rtm1Kopf/Il21rtm1Kopf
Genetic Background: B6.129-Il21rtm1Kopf

Allelic Composition: Il21rtm1Wjl/Il21rtm1Wjl
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Il21rtm1Wjl/Il21rtm1Wjl,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129 * C57BL/6

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd81tm1Geha/Cd81tm1Geha
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Srebf1tm2Jdh/Srebf1tm2Jdh
Genetic Background: involves: 129S/SvEvBrd * C57BL/6

Allelic Composition: Il21rtm1Kopf/Il21rtm1Kopf
Genetic Background: B6.129-Il21rtm1Kopf

Allelic Composition: Il21rtm1Wjl/Il21rtm1Wjl
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Il21rtm1Day/Il21rtm1Day
Genetic Background: involves: BALB/c * C57BL/6

 MP:0002500 granulomatous inflammation "chronic inflammation resulting from the failure of the acute inflammatory response and persistance of the injurious agent; characterized by a central area of marcophages, often fused into giant cells, and surrounded by T cells " [Pathology:ISBN 0-397-51047-0, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Srebf1tm2Jdh/Srebf1tm2Jdh
Genetic Background: involves: 129S/SvEvBrd * C57BL/6

 MP:0002607 decreased basophil count "lower than average number of basophils as measured by the percent of the total number of leukocytes" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, MPD:Mouse Phenome Database]
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Allelic Composition: Il21rtm1Kopf/Il21rtm1Kopf
Genetic Background: B6.129-Il21rtm1Kopf

 MP:0003850 abnormal thymocyte activation/response "anomaly in the process of producing activated thymocytes from naive thymocytes" [mberry:Melissa Berry, Genetics Resources Curator]
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Allelic Composition: Il21rtm1Day/Il21rtm1Day
Genetic Background: involves: BALB/c * C57BL/6

 MP:0003945 abnormal lymphocyte physiology "abnormal function of any of the white blood cells that includes B cells, T cells, and NK cells " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Srebf1tm2Jdh/Srebf1tm2Jdh
Genetic Background: involves: 129S/SvEvBrd * C57BL/6

Allelic Composition: Il21rtm1Kopf/Il21rtm1Kopf
Genetic Background: B6.129-Il21rtm1Kopf

 MP:0004392 abnormal CD8-positive T cell physiology "abnormal function of the subset of T lymphocytes that express the CD8 marker on the cell surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il21rtm1Wjl/Il21rtm1Wjl
Genetic Background: involves: 129 * C57BL/6

 MP:0004799 increased susceptibility to experimental autoimmune encephalomyelitis "greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il21rtm1Kopf/Il21rtm1Kopf
Genetic Background: B6.129-Il21rtm1Kopf

 MP:0004802 decreased susceptibility to systemic lupus erythematosus "reduced likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pofut1tm1Pst/Pofut1cax
Genetic Background: involves: 129/Sv * C57BL/6J * SJL/J

 MP:0004804 decreased susceptibility to autoimmune diabetes "reduced likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat3tm1Dlv/Stat3tm1Dlv,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0005012 decreased eosinophil count "fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il21rtm1Kopf/Il21rtm1Kopf
Genetic Background: B6.129-Il21rtm1Kopf

 MP:0005070 defective NK cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:6213]
Show

Allelic Composition: Il21rtm1Day/Il21rtm1Day
Genetic Background: involves: BALB/c * C57BL/6

 MP:0005079 defective cytotoxic T cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:6692]
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Allelic Composition: Il21rtm1Wjl/Il21rtm1Wjl
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Il21rtm1Day/Il21rtm1Day
Genetic Background: involves: BALB/c * C57BL/6

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Stat3tm1Dlv/Stat3tm1Dlv,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0005362 abnormal Langerhans cell physiology "atypical or failure of normal function of the phagocytic dendritic cells principally found in the epidemis" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il21rtm1Day/Il21rtm1Day
Genetic Background: involves: BALB/c * C57BL/6

 MP:0005465 abnormal T helper 1 physiology "anomalous response of the subset of helper T cells that enhance cell-mediated immune responses; these cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Il21rtm1Kopf/Il21rtm1Kopf
Genetic Background: B6.129-Il21rtm1Kopf

 MP:0005466 abnormal T helper 2 physiology "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il21rtm1Kopf/Il21rtm1Kopf
Genetic Background: B6.129-Il21rtm1Kopf

Allelic Composition: Il21rtm1Day/Il21rtm1Day
Genetic Background: C57BL/6-Il21rtm1Day

 MP:0005616 decreased susceptibility to type IV hypersensitivity reaction "less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il21rtm1Day/Il21rtm1Day
Genetic Background: involves: BALB/c * C57BL/6

 MP:0008051 abnormal memory T cell physiology "any functional anomaly of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Il21rtm1Day/Il21rtm1Day
Genetic Background: involves: BALB/c * C57BL/6

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il21rtm1Day/Il21rtm1Day
Genetic Background: involves: BALB/c * C57BL/6

 MP:0008076 abnormal CD4-positive T cell differentiation "atypical production of or inability to produce the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat3tm1Dlv/Stat3tm1Dlv,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

Allelic Composition: Il21rtm1Day/Il21rtm1Day
Genetic Background: involves: BALB/c * C57BL/6

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Srebf1tm2Jdh/Srebf1tm2Jdh
Genetic Background: involves: 129S/SvEvBrd * C57BL/6

Allelic Composition: Il21rtm1Kopf/Il21rtm1Kopf
Genetic Background: B6.129-Il21rtm1Kopf

Allelic Composition: Il21rtm1Wjl/Il21rtm1Wjl
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Il21rtm1Wjl/Il21rtm1Wjl,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Il21rtm1Day/Il21rtm1Day
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Il21rtm1Day/Il21rtm1Day
Genetic Background: C57BL/6-Il21rtm1Day

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Il21rtm1Wjl/Il21rtm1Wjl
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Il21rtm1Wjl/Il21rtm1Wjl,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Il21rtm1Day/Il21rtm1Day
Genetic Background: involves: BALB/c * C57BL/6

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Il21rtm1Wjl/Il21rtm1Wjl
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Il21rtm1Wjl/Il21rtm1Wjl,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Il21rtm1Day/Il21rtm1Day
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Il21rtm1Day/Il21rtm1Day
Genetic Background: C57BL/6-Il21rtm1Day

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Il21rtm1Wjl/Il21rtm1Wjl
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Il21rtm1Wjl/Il21rtm1Wjl,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129 * C57BL/6

 MP:0008522 abnormal lymph node germinal center "any strucutral anomaly of the area of the lymph node secondary follicle where B cells are stimulated by antigens and helper T cells are stimulated to generate memory cells" [MESH:A10.549.400.500, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il21rtm1Wjl/Il21rtm1Wjl,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129 * C57BL/6

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Il21rtm1Day/Il21rtm1Day
Genetic Background: involves: BALB/c * C57BL/6

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Il21rtm1Day/Il21rtm1Day
Genetic Background: involves: BALB/c * C57BL/6

 MP:0008673 decreased interleukin-13 secretion "reduction in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
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Allelic Composition: Il21rtm1Day/Il21rtm1Day
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Il21rtm1Day/Il21rtm1Day
Genetic Background: C57BL/6-Il21rtm1Day

 MP:0008682 decreased interleukin-17 secretion "reduction in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
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Allelic Composition: Il21rtm1Wjl/Il21rtm1Wjl
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Il21rtm1Wjl/Il21rtm1Wjl
Genetic Background: NOD.Cg-Il21rtm1Wjl

Allelic Composition: Il21rtm1Day/Il21rtm1Day
Genetic Background: involves: BALB/c * C57BL/6

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Il21rtm1Day/Il21rtm1Day
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Il21rtm1Day/Il21rtm1Day
Genetic Background: C57BL/6-Il21rtm1Day

 MP:0008723 impaired eosinophil recruitment "reduced diffusion or accumulation of eosinophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Srebf1tm2Jdh/Srebf1tm2Jdh
Genetic Background: involves: 129S/SvEvBrd * C57BL/6

Allelic Composition: Il21rtm1Kopf/Il21rtm1Kopf
Genetic Background: B6.129-Il21rtm1Kopf

 MP:0008769 abnormal plasmacytoid dendritic cell physiology "any functional anomaly of phagocytic dendritic cells that are morphologically similar to plasma cells, but do not express B lineage markers, and produce large amounts of alpha/beta interferons (IFN-/) in response to viral and bacterial stimuli; plasmacytoid dendritic cells are found in the thymic medulla and lymph node T cell areas and are responsible for immune tolerance" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il21rtm1Day/Il21rtm1Day
Genetic Background: involves: BALB/c * C57BL/6

 MP:0009058 decreased interleukin-21 secretion "reduction in the production or release of a pleiotropic cytokine that regulates immunoglobulin production, plasma cell and Th17 T cell differentiation, CD8+ T cell expansion, and inhibits antigen presentation by dendritic cells" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Il21rtm1Day/Il21rtm1Day
Genetic Background: C57BL/6-Il21rtm1Day

 MP:0010766 abnormal NK cell physiology "any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]
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Allelic Composition: Il21rtm1Day/Il21rtm1Day
Genetic Background: involves: BALB/c * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000062939 Stat4 / signal transducer and activator of transcription 4 / Q14765*  / complex
 ENSMUSG00000031304 Il2rg / P34902 / Cytokine receptor common subunit gamma / P31785* / AL590764.2* / interleukin 2 receptor subunit gamma*  / complex
 ENSMUSG00000027718 Il21 / Q9ES17 / Interleukin-21 / Q9HBE4*  / complex
 ENSMUSG00000031805 Jak3 / Janus kinase 3 / P52333*  / complex
 ENSMUSG00000004040 Stat3 / P42227 / Signal transducer and activator of transcription 3 / P40763*  / complex
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / complex






 

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