ENSMUSG00000030781


Mus musculus

Features
Gene ID: ENSMUSG00000030781
  
Biological name :Slc5a2
  
Synonyms : Q923I7 / Slc5a2 / Sodium/glucose cotransporter 2
  
Possible biological names infered from orthology : P31639 / solute carrier family 5 member 2
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: F3
Gene start: 128265657
Gene end: 128272430
  
Corresponding Affymetrix probe sets: 10557975 (MoGene1.0st)   1419166_at (Mouse Genome 430 2.0 Array)   1455005_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000115451
Ensembl peptide - ENSMUSP00000145789
Ensembl peptide - ENSMUSP00000145739
Ensembl peptide - ENSMUSP00000145699
Ensembl peptide - ENSMUSP00000145615
Ensembl peptide - ENSMUSP00000145581
Ensembl peptide - ENSMUSP00000145578
Ensembl peptide - ENSMUSP00000124318
Ensembl peptide - ENSMUSP00000112597
NCBI entrez gene - 246787     See in Manteia.
MGI - MGI:2181411
RefSeq - NM_133254
RefSeq Peptide - NP_573517
swissprot - A0A0U1RNT9
swissprot - A0A0U1RNL6
swissprot - A0A0U1RNI8
swissprot - A0A0U1RNI5
swissprot - F6TFB9
swissprot - D3Z0A1
swissprot - Q923I7
swissprot - A0A0U1RP15
swissprot - A0A0U1RNX5
Ensembl - ENSMUSG00000030781
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc5a2ENSDARG00000100919Danio rerio
 P31639ENSG00000140675Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Slc5a1 / solute carrier family 5 (sodium/glucose cotransporter), member 1 / P13866* / solute carrier family 5 member 1*ENSMUSG0000001103459
Slc5a4b / solute carrier family 5 (neutral amino acid transporters, system A), member 4b / Q9NY91* / SLC5A4* / solute carrier family 5 member 4*ENSMUSG0000002022657
Slc5a4a / Q9NY91* / SLC5A4* / solute carrier family 5 member 4*ENSMUSG0000002022954
Q8VDT1 / Slc5a9 / Sodium/glucose cotransporter 4 / Q2M3M2* / solute carrier family 5 member 9*ENSMUSG0000002854453
Q8K0E3 / Slc5a11 / Sodium/myo-inositol cotransporter 2 / Q8WWX8* / solute carrier family 5 member 11*ENSMUSG0000003076950
Q5SWY8 / Slc5a10 / Sodium/glucose cotransporter 5 / A0PJK1* / solute carrier family 5 member 10*ENSMUSG0000004237149
Gm5134ENSMUSG0000003325544
Q9JKZ2 / Slc5a3 / Sodium/myo-inositol cotransporter / P53794* / solute carrier family 5 member 3*ENSMUSG0000008977444
Slc5a5 / solute carrier family 5 member 5 / Q92911*ENSMUSG0000000079221
Q5U4D8 / Slc5a6 / Sodium-dependent multivitamin transporter / Q9Y289* / solute carrier family 5 member 6*ENSMUSG0000000664119
Q8BYF6 / Slc5a8 / Sodium-coupled monocarboxylate transporter 1 / Q8N695* / solute carrier family 5 member 8*ENSMUSG0000002006218
Q49B93 / Slc5a12 / solute carrier family 5 (sodium/glucose cotransporter), member 12 / Q1EHB4* / solute carrier family 5 member 12*ENSMUSG0000004164418


Protein motifs (from Interpro)
Interpro ID Name
 IPR001734  Sodium/solute symporter
 IPR018212  Sodium/solute symporter, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006814 sodium ion transport IBA
 biological_processGO:0008643 carbohydrate transport IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:1904659 glucose transmembrane transport IBA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005412 glucose:sodium symporter activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015293 symporter activity IEA
 molecular_functionGO:0022857 transmembrane transporter activity IEA


Pathways (from Reactome)
Pathway description
Cellular hexose transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Slc5a1Gt(OST315271)Lex/Slc5a1Gt(OST315271)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0000188 abnormal circulating glucose level "anomalous concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc5a1Gt(OST315271)Lex/Slc5a1Gt(OST315271)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0000198 hypophosphatemia "abnormally low concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Slc5a1Gt(OST315271)Lex/Slc5a1Gt(OST315271)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Slc5a1Gt(OST315271)Lex/Slc5a1Gt(OST315271)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Slc5a1Gt(OST315271)Lex/Slc5a1Gt(OST315271)Lex,Slc5a2tm1Lex/Slc5a2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001759 increased urine glucose level "a greater level of excretion of glucose in the urine compared to the normal state" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Slc6a4tm1.1Rbl/Slc6a4tm1.1Rbl
Genetic Background: 129S6/SvEvTac-Slc6a4tm1.1Rbl

Allelic Composition: Slc5a2tm1Lex/Slc5a2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Slc5a1Gt(OST315271)Lex/Slc5a1Gt(OST315271)Lex,Slc5a2tm1Lex/Slc5a2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Slc6a4tm1.1Rbl/Slc6a4tm1.1Rbl
Genetic Background: 129S6/SvEvTac-Slc6a4tm1.1Rbl

 MP:0002667 decreased circulating aldosterone level "decreased blood concentration of this hormone, secreted by the adrenal cortex, in the bloodstream; regulates sodium conservation and potassium secretion in the distal renal tubule" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Slc6a4tm1.1Rbl/Slc6a4tm1.1Rbl
Genetic Background: 129S6/SvEvTac-Slc6a4tm1.1Rbl

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Slc5a2tm1Lex/Slc5a2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Slc5a1Gt(OST315271)Lex/Slc5a1Gt(OST315271)Lex,Slc5a2tm1Lex/Slc5a2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002901 hyperphosphaturia "an increase of excretion of phosphates in the urine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Slc5a2tm1Lex/Slc5a2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002988 decreased urine osmolarity "reduction in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]
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Allelic Composition: Slc6a4tm1.1Rbl/Slc6a4tm1.1Rbl
Genetic Background: 129S6/SvEvTac-Slc6a4tm1.1Rbl

 MP:0003019 increased circulating chloride level "elevated concentration of chlorine salts in the circulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Slc5a2tm1Lex/Slc5a2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0004804 decreased susceptibility to autoimmune diabetes "reduced likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc5a2tm1Lex/Slc5a2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Slc5a2tm1Lex/Slc5a2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Slc5a1Gt(OST315271)Lex/Slc5a1Gt(OST315271)Lex,Slc5a2tm1Lex/Slc5a2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005556 abnormal kidney clearance "altered ability of the kidneys to remove substances from the plasma for excretion in a specific period of time" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc6a4tm1.1Rbl/Slc6a4tm1.1Rbl
Genetic Background: 129S6/SvEvTac-Slc6a4tm1.1Rbl

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Slc5a2tm1Lex/Slc5a2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Slc5a1Gt(OST315271)Lex/Slc5a1Gt(OST315271)Lex,Slc5a2tm1Lex/Slc5a2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005582 increased renin activity "greater than the normal ability of this enzyme to cleave angiotensinogen and create angiotensin I" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Slc6a4tm1.1Rbl/Slc6a4tm1.1Rbl
Genetic Background: 129S6/SvEvTac-Slc6a4tm1.1Rbl

 MP:0005619 increased potassium excretion "greater than the normal amount of this alkaline metallic element, the most abundant intracellular ion, voided by the kidneys" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Slc5a2tm1Lex/Slc5a2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Slc5a1Gt(OST315271)Lex/Slc5a1Gt(OST315271)Lex,Slc5a2tm1Lex/Slc5a2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005633 increased circulating sodium level "greater than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Slc5a2tm1Lex/Slc5a2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0006316 increased urine sodium level "higher than normal concentration of sodium in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc5a2tm1Lex/Slc5a2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Slc5a1Gt(OST315271)Lex/Slc5a1Gt(OST315271)Lex,Slc5a2tm1Lex/Slc5a2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc5a2tm1Lex/Slc5a2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc5a2tm1Lex/Slc5a2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Slc5a1Gt(OST315271)Lex/Slc5a1Gt(OST315271)Lex,Slc5a2tm1Lex/Slc5a2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc5a2tm1Lex/Slc5a2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Slc5a1Gt(OST315271)Lex/Slc5a1Gt(OST315271)Lex,Slc5a2tm1Lex/Slc5a2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0010868 increased bone trabecula number "increased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc5a2tm1Lex/Slc5a2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0011435 increased urine magnesium level "higher than normal amount of magnesium in the urine" [MGI:anna]
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Allelic Composition: Slc5a2tm1Lex/Slc5a2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Slc5a1Gt(OST315271)Lex/Slc5a1Gt(OST315271)Lex,Slc5a2tm1Lex/Slc5a2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0011447 abnormal renal glucose reabsorption "any anomaly in the process in which glucose is taken up from the collecting ducts and proximal and distal loops of the nephron" [GO:0035623]
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Allelic Composition: Slc6a4tm1.1Rbl/Slc6a4tm1.1Rbl
Genetic Background: 129S6/SvEvTac-Slc6a4tm1.1Rbl

 MP:0011459 increased urine chloride ion level "abnormally large amounts of chloride ion in the urine" [MGI:csmith]
Show

Allelic Composition: Slc5a2tm1Lex/Slc5a2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Slc5a1Gt(OST315271)Lex/Slc5a1Gt(OST315271)Lex,Slc5a2tm1Lex/Slc5a2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0011466 increased urine urea nitrogen level "abnormally high amounts of nitrogen in the form of urea in the urine" [MGI:csmith]
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Allelic Composition: Slc5a2tm1Lex/Slc5a2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Slc5a1Gt(OST315271)Lex/Slc5a1Gt(OST315271)Lex,Slc5a2tm1Lex/Slc5a2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0011470 increased urine creatinine level "an increased amount of creatinine in the urine compared to the normal state" [MGI:csmith]
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Allelic Composition: Slc5a2tm1Lex/Slc5a2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0011923 abnormal urine volume "any anomaly in the amount of space occupied by urine in the bladder" [MPD:Molly]
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Allelic Composition: Slc5a2tm1Lex/Slc5a2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Slc5a1Gt(OST315271)Lex/Slc5a1Gt(OST315271)Lex,Slc5a2tm1Lex/Slc5a2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Slc6a4tm1.1Rbl/Slc6a4tm1.1Rbl
Genetic Background: 129S6/SvEvTac-Slc6a4tm1.1Rbl

Allelic Composition: Slc5a2tm1Lex/Slc5a2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Slc5a1Gt(OST315271)Lex/Slc5a1Gt(OST315271)Lex,Slc5a2tm1Lex/Slc5a2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0011941 increased fluid intake "increase in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Slc6a4tm1.1Rbl/Slc6a4tm1.1Rbl
Genetic Background: 129S6/SvEvTac-Slc6a4tm1.1Rbl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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