ENSMUSG00000042371


Mus musculus

Features
Gene ID: ENSMUSG00000042371
  
Biological name :Slc5a10
  
Synonyms : Q5SWY8 / Slc5a10 / Sodium/glucose cotransporter 5
  
Possible biological names infered from orthology : A0PJK1 / solute carrier family 5 member 10
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B2
Gene start: 61672781
Gene end: 61720826
  
Corresponding Affymetrix probe sets: 10386758 (MoGene1.0st)   1440834_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000054407
Ensembl peptide - ENSMUSP00000114523
Ensembl peptide - ENSMUSP00000118196
NCBI entrez gene - 109342     See in Manteia.
MGI - MGI:1926089
RefSeq - XM_017314221
RefSeq - NM_001033227
RefSeq - XM_006531978
RefSeq - XM_006531979
RefSeq - XM_006531980
RefSeq Peptide - NP_001028399
swissprot - Q5SWY8
swissprot - F6UXY4
Ensembl - ENSMUSG00000042371
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SLC5A10ENSDARG00000074212Danio rerio
 SLC5A10ENSGALG00000005083Gallus gallus
 A0PJK1ENSG00000154025Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8VDT1 / Slc5a9 / Sodium/glucose cotransporter 4 / Q2M3M2* / solute carrier family 5 member 9*ENSMUSG0000002854459
Q923I7 / Slc5a2 / Sodium/glucose cotransporter 2 / P31639* / solute carrier family 5 member 2*ENSMUSG0000003078155
Slc5a1 / solute carrier family 5 (sodium/glucose cotransporter), member 1 / P13866* / solute carrier family 5 member 1*ENSMUSG0000001103453
Q8K0E3 / Slc5a11 / Sodium/myo-inositol cotransporter 2 / Q8WWX8* / solute carrier family 5 member 11*ENSMUSG0000003076952
Slc5a4b / solute carrier family 5 (neutral amino acid transporters, system A), member 4b / Q9NY91* / SLC5A4* / solute carrier family 5 member 4*ENSMUSG0000002022651
Slc5a4a / Q9NY91* / SLC5A4* / solute carrier family 5 member 4*ENSMUSG0000002022949
Q9JKZ2 / Slc5a3 / Sodium/myo-inositol cotransporter / P53794* / solute carrier family 5 member 3*ENSMUSG0000008977446
Gm5134ENSMUSG0000003325541
Slc5a5 / solute carrier family 5 member 5 / Q92911*ENSMUSG0000000079223
Q8BYF6 / Slc5a8 / Sodium-coupled monocarboxylate transporter 1 / Q8N695* / solute carrier family 5 member 8*ENSMUSG0000002006221
Q5U4D8 / Slc5a6 / Sodium-dependent multivitamin transporter / Q9Y289* / solute carrier family 5 member 6*ENSMUSG0000000664120
Q49B93 / Slc5a12 / solute carrier family 5 (sodium/glucose cotransporter), member 12 / Q1EHB4* / solute carrier family 5 member 12*ENSMUSG0000004164420


Protein motifs (from Interpro)
Interpro ID Name
 IPR001734  Sodium/solute symporter
 IPR018212  Sodium/solute symporter, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006814 sodium ion transport IBA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:1904659 glucose transmembrane transport IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005412 glucose:sodium symporter activity IBA
 molecular_functionGO:0022857 transmembrane transporter activity IEA


Pathways (from Reactome)
Pathway description
Cellular hexose transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tdp2tm1Huy/Tdp2tm1Huy
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tdp2tm1Huy/Tdp2tm1Huy
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tdp2tm1Huy/Tdp2tm1Huy
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tdp2tm1Huy/Tdp2tm1Huy
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0002965 hyperalbuminemia "blood albumin concentration above the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Tdp2tm1Huy/Tdp2tm1Huy
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tdp2tm1Huy/Tdp2tm1Huy
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
Show

Allelic Composition: Tdp2tm1Huy/Tdp2tm1Huy
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0009289 decreased epididymal fat pad weight 
Show

Allelic Composition: Tdp2tm1Huy/Tdp2tm1Huy
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tdp2tm1Huy/Tdp2tm1Huy
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tdp2tm1Huy/Tdp2tm1Huy
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0010107 abnormal renal reabsorption "any anomaly in the two-step process beginning with the active or passive extraction of substances (such as water, glucose, oligopeptides, amino acids, sodium (Na+) and other ions) from the renal tubule fluid into the renal interstitium, and the subsequent transport of these substances out of the renal interstitium back into the bloodstream; reabsorption begins in the proximal convoluted tubules and continues in the loop of Henle, distal convoluted tubules, and collecting tubules" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tdp2tm1Huy/Tdp2tm1Huy
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0011971 increased circulating lactate dehydrogenase level "elevated blood level of the tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of lactate and pyruvate; measurements of circulating levels are used clinically as a diagnostic indicator of tissue breakdown, some forms of cancer or particular infection types" [MeSH:D08.811.682.047.551.400, MGI:csmith]
Show

Allelic Composition: Tdp2tm1Huy/Tdp2tm1Huy
Genetic Background: involves: 129P2/OlaHsd * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr