ENSMUSG00000030834


Mus musculus

Features
Gene ID: ENSMUSG00000030834
  
Biological name :Abcc6
  
Synonyms : Abcc6 / Multidrug resistance-associated protein 6 / Q9R1S7
  
Possible biological names infered from orthology : ATP binding cassette subfamily C member 6 / O95255
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B3
Gene start: 45967555
Gene end: 46030302
  
Corresponding Affymetrix probe sets: 10563447 (MoGene1.0st)   1421212_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000002850
Ensembl peptide - ENSMUSP00000147676
NCBI entrez gene - 27421     See in Manteia.
MGI - MGI:1351634
RefSeq - XM_006540948
RefSeq - NM_018795
RefSeq - XM_006540945
RefSeq - XM_006540946
RefSeq - XM_006540947
RefSeq Peptide - NP_061265
swissprot - Q9R1S7
swissprot - A0A1B0GRV2
Ensembl - ENSMUSG00000030834
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ABCC6ENSG00000091262Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Abcc10 / Q8R4P9 / Mus musculus ATP-binding cassette, sub-family C (CFTR/MRP), member 10 (Abcc10), transcript variant 3, mRNA. / Q5T3U5* / ATP binding cassette subfamily C member 10*ENSMUSG0000003284228


Protein motifs (from Interpro)
Interpro ID Name
 IPR003439  ABC transporter-like
 IPR003593  AAA+ ATPase domain
 IPR011527  ABC transporter type 1, transmembrane domain
 IPR017871  ABC transporter, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR030239  Multidrug resistance-associated protein 6
 IPR036640  ABC transporter type 1, transmembrane domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0055085 transmembrane transport IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0016328 lateral plasma membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0042626 ATPase activity, coupled to transmembrane movement of substances IBA


Pathways (from Reactome)
Pathway description
ABC-family proteins mediated transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Prkacatm3Gsm/Prkacatm3Gsm,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000530 abnormal kidney vasculature "malformation or malfunctioning of the blood vessel network of the organ of excretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
Show

Allelic Composition: Prkacatm3Gsm/Prkacatm3Gsm,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002098 abnormal vibrissae morphology "irregular or unusual structure, appearance, or alignment of the vibrissae" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Socs2tm1Vem/Socs2tm1Vem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002838 resistance to dystrophic cardiac calcinosis "less likely to be stricken by dystrophic cardiac calcinosis" [il:Ira Lu , Mouse Genome Informatics Curator, J:76777]
Show

Allelic Composition: l1Rk3/Mlphln
Genetic Background: involves: C57L/J

Allelic Composition: Abcc6Dyscalc1-C3H/DiSnA/Abcc6Dyscalc1-C57BL/10
Genetic Background: involves: C3H/DiSnA * C57BL/10

Allelic Composition: Abcc6rs32756904-T/Abcc6Dyscalc1-C57BL/6J
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Abcc6Dyscalc1-C57BL/6J/Abcc6Dyscalc1-C57BL/6J
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0002839 susceptibility to dystrophic cardiac calcinosis "more likely to be stricken by dystrophic cardiac calcinosis" [J:76777, il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Mtf1Thyls-BALB/c/Mtf1Thyls-MSM
Genetic Background: involves: BALB/c * MSM

Allelic Composition: Abcc6Dyscalc1-DBA/2J/Abcc6Dyscalc1-DBA/2J
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: Abcc6rs32756904-T/Abcc6rs32756904-T,Dyscalc2C3H/HeJ/?
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Abcc6Dyscalc1-C3H/HeNCrl/Abcc6Dyscalc1-C3H/HeNCrl
Genetic Background: involves: C3H/HeNCrl * C57BL/6NCrl

 MP:0003195 calcinosis "pathologic deposition of calcium salts in tissues " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Il6tm1Poli/Il6tm1Poli
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Abcc6tm1Jfk/Abcc6tm1Jfk,Samd9ltm1Homy/Samd9ltm1Homy
Genetic Background: B6.129-Samd9ltm1Homy Abcc6tm1Jfk

 MP:0003196 skin calcification "pathologic deposition of calcium salts in the skin" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Il6tm1Poli/Il6tm1Poli
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Abcc6tm1Aabb/Abcc6tm1Aabb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003197 kidney calcification "pathologic deposition of calcium salts in the kidney" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Il6tm1Poli/Il6tm1Poli
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0005239 abnormal Bruch membrane morphology "anomalous structure of the transparent, nearly structureless inner layer of the choroid in contact with the pigmented layer of the retina" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Prkacatm3Gsm/Prkacatm3Gsm,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Prkacatm3Gsm/Prkacatm3Gsm,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0006133 arterial calcification "pathologic deposition of calcium salts in the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Il6tm1Poli/Il6tm1Poli
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Abcc6tm1Aabb/Abcc6tm1Aabb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006188 retinal calcification "pathologic deposition of calcium salts in the retina" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Il6tm1Poli/Il6tm1Poli
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0010234 abnormal vibrissa follicle morphology "any structural anomaly of one of the tubular invaginations of the epidermis enclosing the hair roots and from which grow the vibrissae located on the muzzle and face of many species" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il6tm1Poli/Il6tm1Poli
Genetic Background: involves: 129S/SvEv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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