ENSMUSG00000032842


Mus musculus

Features
Gene ID: ENSMUSG00000032842
  
Biological name :Abcc10
  
Synonyms : Abcc10 / Mus musculus ATP-binding cassette, sub-family C (CFTR/MRP), member 10 (Abcc10), transcript variant 3, mRNA. / Q8R4P9
  
Possible biological names infered from orthology : ATP binding cassette subfamily C member 10 / Q5T3U5
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: C
Gene start: 46303221
Gene end: 46328352
  
Corresponding Affymetrix probe sets: 10451261 (MoGene1.0st)   1428009_a_at (Mouse Genome 430 2.0 Array)   1447476_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000038041
Ensembl peptide - ENSMUSP00000131843
Ensembl peptide - ENSMUSP00000132561
Ensembl peptide - ENSMUSP00000132760
Ensembl peptide - ENSMUSP00000092895
NCBI entrez gene - 224814     See in Manteia.
MGI - MGI:2386976
RefSeq - XM_017317442
RefSeq - NM_001347396
RefSeq - NM_145140
RefSeq - NM_170680
RefSeq - XM_006524142
RefSeq - XM_017317441
RefSeq Peptide - NP_660122
RefSeq Peptide - NP_733780
RefSeq Peptide - NP_001334325
swissprot - E9PZG1
swissprot - Q8R4P9
swissprot - E9PY11
Ensembl - ENSMUSG00000032842
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000010419Gallus gallus
 ABCC10ENSG00000124574Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Abcc6 / Q9R1S7 / Multidrug resistance-associated protein 6 / O95255* / ATP binding cassette subfamily C member 6*ENSMUSG0000003083428


Protein motifs (from Interpro)
Interpro ID Name
 IPR003439  ABC transporter-like
 IPR003593  AAA+ ATPase domain
 IPR011527  ABC transporter type 1, transmembrane domain
 IPR017871  ABC transporter, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR036640  ABC transporter type 1, transmembrane domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0055085 transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0042626 ATPase activity, coupled to transmembrane movement of substances IEA


Pathways (from Reactome)
Pathway description
ABC-family proteins mediated transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cop1tm2.1Vmd/Cop1+,Tg(Pbsn-cre)4Prb/0
Genetic Background: B6N.Cg-Cop1tm2.1Vmd Tg(Pbsn-cre)4Prb

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Cop1tm2.1Vmd/Cop1+,Tg(Pbsn-cre)4Prb/0
Genetic Background: B6N.Cg-Cop1tm2.1Vmd Tg(Pbsn-cre)4Prb

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cop1tm2.1Vmd/Cop1+,Tg(Pbsn-cre)4Prb/0
Genetic Background: B6N.Cg-Cop1tm2.1Vmd Tg(Pbsn-cre)4Prb

 MP:0000711 thymic cortex hypoplasia "reduced cell number in the outer portion of the thymus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cop1tm2.1Vmd/Cop1+,Tg(Pbsn-cre)4Prb/0
Genetic Background: B6N.Cg-Cop1tm2.1Vmd Tg(Pbsn-cre)4Prb

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Cop1tm2.1Vmd/Cop1+,Tg(Pbsn-cre)4Prb/0
Genetic Background: B6N.Cg-Cop1tm2.1Vmd Tg(Pbsn-cre)4Prb

 MP:0002356 abnormal spleen red pulp morphology "anomalous structure of the area of the spleen that screens and eliminates defective or foreign cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Cop1tm2.1Vmd/Cop1+,Tg(Pbsn-cre)4Prb/0
Genetic Background: B6N.Cg-Cop1tm2.1Vmd Tg(Pbsn-cre)4Prb

 MP:0008479 decreased spleen white pulp amount "reduction in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cop1tm2.1Vmd/Cop1+,Tg(Pbsn-cre)4Prb/0
Genetic Background: B6N.Cg-Cop1tm2.1Vmd Tg(Pbsn-cre)4Prb

 MP:0008482 decreased spleen germinal center number "reduced number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Cop1tm2.1Vmd/Cop1+,Tg(Pbsn-cre)4Prb/0
Genetic Background: B6N.Cg-Cop1tm2.1Vmd Tg(Pbsn-cre)4Prb

 MP:0008484 decreased spleen germinal center size "reduced size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Cop1tm2.1Vmd/Cop1+,Tg(Pbsn-cre)4Prb/0
Genetic Background: B6N.Cg-Cop1tm2.1Vmd Tg(Pbsn-cre)4Prb

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cop1tm2.1Vmd/Cop1+,Tg(Pbsn-cre)4Prb/0
Genetic Background: B6N.Cg-Cop1tm2.1Vmd Tg(Pbsn-cre)4Prb

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cop1tm2.1Vmd/Cop1+,Tg(Pbsn-cre)4Prb/0
Genetic Background: B6N.Cg-Cop1tm2.1Vmd Tg(Pbsn-cre)4Prb

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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