ENSMUSG00000031451


Mus musculus

Features
Gene ID: ENSMUSG00000031451
  
Biological name :Gas6
  
Synonyms : Gas6 / Growth arrest-specific protein 6 / Q61592
  
Possible biological names infered from orthology : growth arrest specific 6 / Q14393
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: A1.1
Gene start: 13465374
Gene end: 13494490
  
Corresponding Affymetrix probe sets: 10577164 (MoGene1.0st)   1417399_at (Mouse Genome 430 2.0 Array)   1459585_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033828
NCBI entrez gene - 14456     See in Manteia.
MGI - MGI:95660
RefSeq - NM_019521
RefSeq Peptide - NP_062394
swissprot - Q61592
Ensembl - ENSMUSG00000031451
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gas6ENSDARG00000007804Danio rerio
 GAS6ENSGALG00000016820Gallus gallus
 GAS6ENSG00000183087Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pros1 / Q08761 / protein S (alpha) / P07225* / protein S*ENSMUSG0000002291239
Shbg / P97497 / Sex hormone-binding globulin / P04278*ENSMUSG0000000520213


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000294  Gamma-carboxyglutamic acid-rich (GLA) domain
 IPR000742  EGF-like domain
 IPR001791  Laminin G domain
 IPR001881  EGF-like calcium-binding domain
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR013032  EGF-like, conserved site
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR017857  Coagulation factor-like, Gla domain superfamily
 IPR018097  EGF-like calcium-binding, conserved site
 IPR035972  Gamma-carboxyglutamic acid-rich (GLA) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001764 neuron migration IGI
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0001961 positive regulation of cytokine-mediated signaling pathway IEA
 biological_processGO:0003104 positive regulation of glomerular filtration IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006909 phagocytosis IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007167 enzyme linked receptor protein signaling pathway IGI
 biological_processGO:0007596 blood coagulation IMP
 biological_processGO:0009267 cellular response to starvation IDA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:0010934 macrophage cytokine production IMP
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0019064 fusion of virus membrane with host plasma membrane IEA
 biological_processGO:0019079 viral genome replication IEA
 biological_processGO:0031100 animal organ regeneration IEA
 biological_processGO:0031589 cell-substrate adhesion IMP
 biological_processGO:0032008 positive regulation of TOR signaling IEA
 biological_processGO:0032148 activation of protein kinase B activity IEA
 biological_processGO:0032689 negative regulation of interferon-gamma production IEA
 biological_processGO:0032715 negative regulation of interleukin-6 production IEA
 biological_processGO:0032720 negative regulation of tumor necrosis factor production IEA
 biological_processGO:0032825 positive regulation of natural killer cell differentiation IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0033159 negative regulation of protein import into nucleus, translocation IEA
 biological_processGO:0035457 cellular response to interferon-alpha IEA
 biological_processGO:0035690 cellular response to drug IEA
 biological_processGO:0035754 B cell chemotaxis IEA
 biological_processGO:0040008 regulation of growth IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0043277 apoptotic cell clearance IEA
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0043491 protein kinase B signaling IEA
 biological_processGO:0045860 positive regulation of protein kinase activity IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0046718 viral entry into host cell IEA
 biological_processGO:0046813 receptor-mediated virion attachment to host cell IEA
 biological_processGO:0046827 positive regulation of protein export from nucleus IEA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IEA
 biological_processGO:0050711 negative regulation of interleukin-1 secretion IEA
 biological_processGO:0050766 positive regulation of phagocytosis IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:0061098 positive regulation of protein tyrosine kinase activity IEA
 biological_processGO:0070168 negative regulation of biomineral tissue development IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0071307 cellular response to vitamin K IEA
 biological_processGO:0071333 cellular response to glucose stimulus IEA
 biological_processGO:0071363 cellular response to growth factor stimulus IMP
 biological_processGO:0072659 protein localization to plasma membrane IEA
 biological_processGO:0085029 extracellular matrix assembly IEA
 biological_processGO:0097028 dendritic cell differentiation IEA
 biological_processGO:0097241 hematopoietic stem cell migration to bone marrow IEA
 biological_processGO:1900142 negative regulation of oligodendrocyte apoptotic process IEA
 biological_processGO:1900165 negative regulation of interleukin-6 secretion IEA
 biological_processGO:2000270 negative regulation of fibroblast apoptotic process IEA
 biological_processGO:2000352 negative regulation of endothelial cell apoptotic process IEA
 biological_processGO:2000510 positive regulation of dendritic cell chemotaxis IEA
 biological_processGO:2000533 negative regulation of renal albumin absorption IEA
 biological_processGO:2000669 negative regulation of dendritic cell apoptotic process IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0001786 phosphatidylserine binding IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005245 voltage-gated calcium channel activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0030296 protein tyrosine kinase activator activity IEA
 molecular_functionGO:0030971 receptor tyrosine kinase binding IEA
 molecular_functionGO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048018 receptor ligand activity IEA
 molecular_functionGO:0060090 molecular adaptor activity IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
Removal of aminoterminal propeptides from gamma-carboxylated proteins
Cell surface interactions at the vascular wall
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000199 abnormal circulating albumin level "aberrant concentration in the blood of this most abundant of the plasma proteins " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gnl3Gt(W223E05)Wrst/Gnl3Gt(W223E05)Wrst,Trp53tm1Tyj/Trp53tm5Tyj
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Folh1tm1b(KOMP)Wtsi/Folh1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Folh1tm1b(KOMP)Wtsi/J

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Folh1tm1b(KOMP)Wtsi/Folh1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Folh1tm1b(KOMP)Wtsi/J

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0002871 albuminuria "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gnl3Gt(W223E05)Wrst/Gnl3Gt(W223E05)Wrst,Trp53tm1Tyj/Trp53tm5Tyj
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Folh1tm1b(KOMP)Wtsi/Folh1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Folh1tm1b(KOMP)Wtsi/J

 MP:0003070 increased vascular permeability "greater or faster ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0005264 glomerulosclerosis "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gnl3Gt(W223E05)Wrst/Gnl3Gt(W223E05)Wrst,Trp53tm1Tyj/Trp53tm5Tyj
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gnl3Gt(W223E05)Wrst/Gnl3Gt(W223E05)Wrst,Trp53tm1Tyj/Trp53tm5Tyj
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae

 MP:0009446 abnormal platelet dense granule physiology "any functional anomaly of the specialized secretory organelles located in the small, irregularly shaped anuclear cells derived from fragmentation of precursor megakaryocytes that contain adenine nucleotides (ADP and ATP), ionized calcium, histamine, serotonin, and epinephrine" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0009549 impaired platelet aggregation "decrease in the ability of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
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Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0009764 decreased sensitivity to induced morbidity/mortality "increase in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gnl3Gt(W223E05)Wrst/Gnl3Gt(W223E05)Wrst,Trp53tm1Tyj/Trp53tm5Tyj
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae

 MP:0011441 decreased kidney cell proliferation "decrease in the expansion rate of any kidney cell population by cell division" [MGI:anna]
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Allelic Composition: Gnl3Gt(W223E05)Wrst/Gnl3Gt(W223E05)Wrst,Trp53tm1Tyj/Trp53tm5Tyj
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae

 MP:0011506 glomerular crescent "formation of a crescent-shaped (semi-lunar) glomerular lesion corresponding to extracapillary proliferation of Bowman s capsular epithelium and acquiring a fibroblast-like spindled morphology, possibly stimulated by release of fibrinogen from a ruptured glomerular basement membrane; epithelial crescents occur in aggressive forms of glomerulonephritis, may be accompanied by collagen and fibrin deposition and/or monocyte and macrophage proliferation, may protrude into Bowman s space, and ultimately compress and destroy the glomerular tuft" [MGI:anna]
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Allelic Composition: Gnl3Gt(W223E05)Wrst/Gnl3Gt(W223E05)Wrst,Trp53tm1Tyj/Trp53tm5Tyj
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Folh1tm1b(KOMP)Wtsi/Folh1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Folh1tm1b(KOMP)Wtsi/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000014361 Mertk / Q60805 / Tyrosine-protein kinase Mer / Q12866* / MER proto-oncogene, tyrosine kinase*  / complex / reaction
 ENSMUSG00000030530 Furin / P23188 / P09958* / furin, paired basic amino acid cleaving enzyme*  / reaction






 

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