ENSMUSG00000031861


Mus musculus

Features
Gene ID: ENSMUSG00000031861
  
Biological name :Lpar2
  
Synonyms : Lpar2 / lysophosphatidic acid receptor 2
  
Possible biological names infered from orthology : Q9HBW0
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: B3.3
Gene start: 69822429
Gene end: 69831102
  
Corresponding Affymetrix probe sets: 10572235 (MoGene1.0st)   1420576_at (Mouse Genome 430 2.0 Array)   1442291_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034325
Ensembl peptide - ENSMUSP00000128261
NCBI entrez gene - 53978     See in Manteia.
MGI - MGI:1858422
RefSeq - NM_020028
RefSeq Peptide - NP_064412
swissprot - Q6P290
Ensembl - ENSMUSG00000031861
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lpar2aENSDARG00000042338Danio rerio
 lpar2bENSDARG00000042561Danio rerio
 LPAR2ENSG00000064547Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lpar1 / P61793 / Lysophosphatidic acid receptor 1 / Q92633*ENSMUSG0000003866853
Lpar3 / Q9EQ31 / Lysophosphatidic acid receptor 3 / Q9UBY5*ENSMUSG0000003683247
S1pr5 / Q91X56 / Sphingosine 1-phosphate receptor 5 / Q9H228*ENSMUSG0000004508734
S1pr1 / O08530 / Sphingosine 1-phosphate receptor 1 / P21453*ENSMUSG0000004509233
S1pr2 / P52592 / Sphingosine 1-phosphate receptor 2 / O95136*ENSMUSG0000004389532
S1pr3 / Q9Z0U9 / Sphingosine 1-phosphate receptor 3 / Q99500*ENSMUSG0000006758632
S1pr4 / Q9Z0L1 / Sphingosine 1-phosphate receptor 4 / O95977*ENSMUSG0000004419931
Gpr6 / Q6YNI2 / G-protein coupled receptor 6 / P46095*ENSMUSG0000004692228
Gpr3 / P35413 / G-protein coupled receptor 3 / P46089*ENSMUSG0000004964926
Gpr12 / P35412 / G-protein coupled receptor 12 / P47775*ENSMUSG0000004146825
Cnr1 / P47746 / Mus musculus cannabinoid receptor 1 (brain) (Cnr1), transcript variant 2, mRNA. / P21554* / cannabinoid receptor 1*ENSMUSG0000004428823
Cnr2 / P47936 / Cannabinoid receptor 2 / P34972*ENSMUSG0000006258523


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR004065  Lysophosphatidic acid receptor
 IPR004066  Lysophosphatidic acid receptor EDG-4
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030139 endocytic vesicle IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0070915 lysophosphatidic acid receptor activity IEA


Pathways (from Reactome)
Pathway description
G alpha (q) signalling events
G alpha (i) signalling events
Lysosphingolipid and LPA receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr,Tg(Col2a1/Acan-rtTA,tetO-cre)#Vlf/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001952 increased airway responsiveness "more easily provoked into bronchoconstriction in bronchial provocation tests" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr,Tg(Col2a1/Acan-rtTA,tetO-cre)#Vlf/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1tm1(cre)Krj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
Show

Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr,Tg(Col2a1/Acan-rtTA,tetO-cre)#Vlf/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr,Tg(Col2a1/Acan-rtTA,tetO-cre)#Vlf/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Plppr4tm2.1Roni/Plppr4tm2.1Roni
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005596 increased susceptibility to type I hypersensitvity reaction "greater likelihood of developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr,Tg(Col2a1/Acan-rtTA,tetO-cre)#Vlf/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr,Tg(Col2a1/Acan-rtTA,tetO-cre)#Vlf/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008661 decreased interleukin-10 secretion "reduction in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
Show

Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr,Tg(Col2a1/Acan-rtTA,tetO-cre)#Vlf/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008672 increased interleukin-13 secretion "increase in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
Show

Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr,Tg(Col2a1/Acan-rtTA,tetO-cre)#Vlf/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010935 increased airway resistance "greater opposition to flow of air caused by the forces of friction, measured as the ratio of driving pressure to the rate of air flow" [MGI:csmith]
Show

Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr,Tg(Col2a1/Acan-rtTA,tetO-cre)#Vlf/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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