ENSMUSG00000041468


Mus musculus

Features
Gene ID: ENSMUSG00000041468
  
Biological name :Gpr12
  
Synonyms : Gpr12 / G-protein coupled receptor 12 / P35412
  
Possible biological names infered from orthology : P47775
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: G3
Gene start: 146582398
Gene end: 146585239
  
Corresponding Affymetrix probe sets: 10535732 (MoGene1.0st)   1449472_at (Mouse Genome 430 2.0 Array)   1457702_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000143653
Ensembl peptide - ENSMUSP00000038245
Ensembl peptide - ENSMUSP00000142889
Ensembl peptide - ENSMUSP00000143415
NCBI entrez gene - 14738     See in Manteia.
MGI - MGI:101909
RefSeq - XM_017320668
RefSeq - NM_001010941
RefSeq - NM_008151
RefSeq - XM_006504806
RefSeq - XM_011241002
RefSeq Peptide - NP_001345984
RefSeq Peptide - NP_001345985
RefSeq Peptide - NP_001345986
RefSeq Peptide - NP_032177
RefSeq Peptide - NP_001010941
swissprot - P35412
swissprot - A0A0G2JG41
swissprot - A0A0G2JGQ1
Ensembl - ENSMUSG00000041468
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gpr12ENSDARG00000062934Danio rerio
 GPR12ENSGALG00000017102Gallus gallus
 GPR12ENSG00000132975Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gpr6 / Q6YNI2 / G-protein coupled receptor 6 / P46095*ENSMUSG0000004692257
Gpr3 / P35413 / G-protein coupled receptor 3 / P46089*ENSMUSG0000004964955
S1pr5 / Q91X56 / Sphingosine 1-phosphate receptor 5 / Q9H228*ENSMUSG0000004508730
Lpar2 / lysophosphatidic acid receptor 2 / Q9HBW0*ENSMUSG0000003186126
S1pr1 / O08530 / Sphingosine 1-phosphate receptor 1 / P21453*ENSMUSG0000004509225
Cnr2 / P47936 / Cannabinoid receptor 2 / P34972*ENSMUSG0000006258525
S1pr3 / Q9Z0U9 / Sphingosine 1-phosphate receptor 3 / Q99500*ENSMUSG0000006758625
S1pr2 / P52592 / Sphingosine 1-phosphate receptor 2 / O95136*ENSMUSG0000004389524
S1pr4 / Q9Z0L1 / Sphingosine 1-phosphate receptor 4 / O95977*ENSMUSG0000004419924
Cnr1 / P47746 / Mus musculus cannabinoid receptor 1 (brain) (Cnr1), transcript variant 2, mRNA. / P21554* / cannabinoid receptor 1*ENSMUSG0000004428824
Lpar1 / P61793 / Lysophosphatidic acid receptor 1 / Q92633*ENSMUSG0000003866823
Lpar3 / Q9EQ31 / Lysophosphatidic acid receptor 3 / Q9UBY5*ENSMUSG0000003683221


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000599  G protein-coupled receptor 12
 IPR000723  G protein-coupled receptor 3/6/12 orphan
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006874 cellular calcium ion homeostasis IDA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0031210 phosphatidylcholine binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000182 increased circulating LDL cholesterol level "greater than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Npr1tm1(Npr1)Unc/Npr1tm1(Npr1)Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Npr1tm1(Npr1)Unc/Npr1tm1(Npr1)Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Npr1tm1(Npr1)Unc/Npr1tm1(Npr1)Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
Show

Allelic Composition: Npr1tm1(Npr1)Unc/Npr1tm1(Npr1)Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Npr1tm1(Npr1)Unc/Npr1tm1(Npr1)Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Npr1tm1(Npr1)Unc/Npr1tm1(Npr1)Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005278 abnormal cholesterol homeostasis "anomaly in the state of equilibrium in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:71350]
Show

Allelic Composition: Npr1tm1(Npr1)Unc/Npr1tm1(Npr1)Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005450 abnormal energy expenditure "utilization of calories that differs from the norm " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Npr1tm1(Npr1)Unc/Npr1tm1(Npr1)Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005458 increased percent body fat "more fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Npr1tm1(Npr1)Unc/Npr1tm1(Npr1)Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Npr1tm1(Npr1)Unc/Npr1tm1(Npr1)Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009285 increased gonadal fat pad weight "greater than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Npr1tm1(Npr1)Unc/Npr1tm1(Npr1)Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009304 increased retroperitoneal fat pad weight 
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Allelic Composition: Npr1tm1(Npr1)Unc/Npr1tm1(Npr1)Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Npr1tm1(Npr1)Unc/Npr1tm1(Npr1)Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010379 decreased respiratory quotient "reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Npr1tm1(Npr1)Unc/Npr1tm1(Npr1)Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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