ENSMUSG00000032015


Mus musculus

Features
Gene ID: ENSMUSG00000032015
  
Biological name :Pou2f3
  
Synonyms : Pou2f3 / POU domain, class 2, transcription factor 3
  
Possible biological names infered from orthology : POU class 2 homeobox 3 / Q9UKI9
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A5.1
Gene start: 43123939
Gene end: 43210369
  
Corresponding Affymetrix probe sets: 10592705 (MoGene1.0st)   1450507_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034513
Ensembl peptide - ENSMUSP00000135115
NCBI entrez gene - 18988     See in Manteia.
MGI - MGI:102565
RefSeq - NM_011139
RefSeq - XM_011242420
RefSeq Peptide - NP_035269
swissprot - H3BJT4
swissprot - Q3U5D1
Ensembl - ENSMUSG00000032015
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pou2f3ENSDARG00000052387Danio rerio
 POU2F3ENSGALG00000006673Gallus gallus
 POU2F3ENSG00000137709Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pou2f2 / Q00196 / POU domain, class 2, transcription factor 2 / P09086* / POU class 2 homeobox 2*ENSMUSG0000000849649
P25425 / Pou2f1 / POU domain, class 2, transcription factor 1 / P14859* / POU class 2 homeobox 1*ENSMUSG0000002656548
P31361 / Pou3f3 / POU domain, class 3, transcription factor 3 / P20264* / POU class 3 homeobox 3*ENSMUSG0000004551532
P31360 / Pou3f2 / POU domain, class 3, transcription factor 2 / P20265* / POU class 3 homeobox 2*ENSMUSG0000009513930
P20263 / Pou5f1 / POU domain, class 5, transcription factor 1 / Q06416* / Q01860* / POU5F1B* / POU class 5 homeobox 1* / POU class 5 homeobox 1B*ENSMUSG0000002440629
P62515 / Pou3f4 / POU domain, class 3, transcription factor 4 / P49335* / POU class 3 homeobox 4*ENSMUSG0000005685429
P21952 / Pou3f1 / POU domain, class 3, transcription factor 1 / Q03052* / POU class 3 homeobox 1*ENSMUSG0000009012529
Pou1f1 / Q00286 / POU domain, class 1, transcription factor 1 / P28069* / POU class 1 homeobox 1*ENSMUSG0000000484223
P17208 / Pou4f1 / POU domain, class 4, transcription factor 1 / Q01851* / POU class 4 homeobox 1*ENSMUSG0000004834923
Pou4f3 / Q63955 / POU domain, class 4, transcription factor 3 / Q15319* / POU class 4 homeobox 3*ENSMUSG0000002449722
Pou4f2 / Q63934 / POU domain, class 4, transcription factor 2 / Q12837* / POU class 4 homeobox 2*ENSMUSG0000003168822
Pou5f2 / POU domain class 5, transcription factor 2 / Q8N7G0*ENSMUSG0000009366819


Protein motifs (from Interpro)
Interpro ID Name
 IPR000327  POU-specific domain
 IPR000972  Octamer-binding transcription factor
 IPR001356  Homeobox domain
 IPR001387  Cro/C1-type helix-turn-helix domain
 IPR009057  Homeobox-like domain superfamily
 IPR010982  Lambda repressor-like, DNA-binding domain superfamily
 IPR013847  POU domain
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0043922 negative regulation by host of viral transcription IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Pik3c2atm1b(EUCOMM)Hmgu/Pik3c2a+
Genetic Background: C57BL/6N-Pik3c2atm1b(EUCOMM)Hmgu/Tcp

 MP:0001423 abnormal liquid preference "the desire to drink more or less fluids than average, or to drink unusual fluids" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ay/Ay
Genetic Background: 101-Ay

 MP:0002656 abnormal keratinocyte differentiation "developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern
Genetic Background: involves: 129P2/OlaHsd

 MP:0004209 abnormal sweet taste sensitivity "changes in the ability to perceive a particular flavor or suggestion of something sweet by the chemoreceptors of the gustatory system" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ay/Ay
Genetic Background: 101-Ay

 MP:0004210 abnormal bitter taste sensitivity "changes in the ability to perceive a particular flavor or suggestion of something bitter by the chemoreceptors of the gustatory system" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ay/Ay
Genetic Background: 101-Ay

 MP:0004213 abnormal unami taste sensitivity "changes in the ability to perceive a particular flavor or suggestion of something unami (savory) by the chemoreceptors of the gustatory system" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ay/Ay
Genetic Background: 101-Ay

 MP:0006260 abnormal gustatory papillae taste buds "malformation, absence, or atypical size or shape of the taste buds located on the gustatory papillae, which includes the fungiform, foliate, and circumvallate papillae" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:55127]
Show

Allelic Composition: Ay/Ay
Genetic Background: 101-Ay

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Pou2f3tm1Rsd/Pou2f3tm1Rsd,Pou3f1tm1Rsd/Pou3f1tm1Rsd
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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