ENSMUSG00000045515


Mus musculus

Features
Gene ID: ENSMUSG00000045515
  
Biological name :Pou3f3
  
Synonyms : P31361 / Pou3f3 / POU domain, class 3, transcription factor 3
  
Possible biological names infered from orthology : P20264 / POU class 3 homeobox 3
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: B
Gene start: 42695768
Gene end: 42703176
  
Corresponding Affymetrix probe sets: 10345879 (MoGene1.0st)   1422331_at (Mouse Genome 430 2.0 Array)   1429857_at (Mouse Genome 430 2.0 Array)   1435197_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000052088
NCBI entrez gene - 18993     See in Manteia.
MGI - MGI:102564
RefSeq - NM_008900
RefSeq Peptide - NP_032926
swissprot - P31361
Ensembl - ENSMUSG00000045515
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 P20264ENSG00000198914Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P31360 / Pou3f2 / POU domain, class 3, transcription factor 2 / P20265* / POU class 3 homeobox 2*ENSMUSG0000009513954
P21952 / Pou3f1 / POU domain, class 3, transcription factor 1 / Q03052* / POU class 3 homeobox 1*ENSMUSG0000009012550
P62515 / Pou3f4 / POU domain, class 3, transcription factor 4 / P49335* / POU class 3 homeobox 4*ENSMUSG0000005685449
P25425 / Pou2f1 / POU domain, class 2, transcription factor 1 / P14859* / POU class 2 homeobox 1*ENSMUSG0000002656530
Pou2f2 / Q00196 / POU domain, class 2, transcription factor 2 / P09086* / POU class 2 homeobox 2*ENSMUSG0000000849629
Pou2f3 / POU domain, class 2, transcription factor 3 / Q9UKI9* / POU class 2 homeobox 3*ENSMUSG0000003201528
P20263 / Pou5f1 / POU domain, class 5, transcription factor 1 / Q06416* / Q01860* / POU5F1B* / POU class 5 homeobox 1* / POU class 5 homeobox 1B*ENSMUSG0000002440625
Pou4f2 / Q63934 / POU domain, class 4, transcription factor 2 / Q12837* / POU class 4 homeobox 2*ENSMUSG0000003168823
Pou1f1 / Q00286 / POU domain, class 1, transcription factor 1 / P28069* / POU class 1 homeobox 1*ENSMUSG0000000484222
P17208 / Pou4f1 / POU domain, class 4, transcription factor 1 / Q01851* / POU class 4 homeobox 1*ENSMUSG0000004834922
Pou4f3 / Q63955 / POU domain, class 4, transcription factor 3 / Q15319* / POU class 4 homeobox 3*ENSMUSG0000002449721
Pou5f2 / POU domain class 5, transcription factor 2 / Q8N7G0*ENSMUSG0000009366818


Protein motifs (from Interpro)
Interpro ID Name
 IPR000327  POU-specific domain
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR010982  Lambda repressor-like, DNA-binding domain superfamily
 IPR013847  POU domain
 IPR016362  POU-domain transcription factor, class 3
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0001822 kidney development IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007588 excretion IMP
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0021799 cerebral cortex radially oriented cell migration IGI
 biological_processGO:0021869 forebrain ventricular zone progenitor cell division IGI
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 biological_processGO:0048878 chemical homeostasis IMP
 biological_processGO:0072218 metanephric ascending thin limb development IMP
 biological_processGO:0072227 metanephric macula densa development IMP
 biological_processGO:0072233 metanephric thick ascending limb development IMP
 biological_processGO:0072236 metanephric loop of Henle development IMP
 biological_processGO:0072240 metanephric DCT cell differentiation IMP
 cellular_componentGO:0005634 nucleus ISO
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0071837 HMG box domain binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000528 delayed kidney development "late onset of the induction and/or differentiation of the kidney" [J:18048]
Show

Allelic Composition: Adamts20bt/Adamts20bt
Genetic Background: DBA

 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Apobtm1Unc/Apob+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Apobtm1Unc/Apob+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Pou3f2tm1Rsd/Pou3f2tm1Rsd,Pou3f3tm1Rmc/Pou3f3tm1Rmc
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Pou3f2tm1Tno/Pou3f2tm1Tno,Pou3f3tm1Tno/Pou3f3tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000790 abnormal stratification in cerebral cortex "abnormal formation or pattern of the layers of the cerebral cortex " [J:64289, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pou3f2tm1Rsd/Pou3f2tm1Rsd,Pou3f3tm1Rmc/Pou3f3tm1Rmc
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Pou3f2tm1Tno/Pou3f2tm1Tno,Pou3f3tm1Tno/Pou3f3tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
Show

Allelic Composition: Apobtm1Unc/Apob+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000819 abnormal olfactory bulb morphology "malformation or absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:16461]
Show

Allelic Composition: Pou3f2tm1Tno/Pou3f2tm1Tno,Pou3f3tm1Tno/Pou3f3tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000854 abnormal cerebellum development "malformed or incomplete differentiation of the part of the metencephalon that lies dorsal to the pons and medulla behind the brain stem and controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Apobtm1Unc/Apob+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Pou3f2tm1Tno/Pou3f2tm1Tno,Pou3f3tm1Tno/Pou3f3tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000857 abnormal cerebellar foliation "malformation of small offshoots of the cerebellar lobules" [Principles of Neural Science:ISBN 0-8385-8034-3, J:52951]
Show

Allelic Composition: Pou3f2tm1Tno/Pou3f2tm1Tno,Pou3f3tm1Tno/Pou3f3tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002703 abnormal renal tubules "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Adamts20bt/Adamts20bt
Genetic Background: DBA

 MP:0002739 abnormal olfactory bulb development "abnormality in the progression of the formation of the olfactory bulb" [J:65380, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pou3f2tm1Rsd/Pou3f2tm1Rsd,Pou3f3tm1Rmc/Pou3f3tm1Rmc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pou3f3urehr2/Pou3f3urehr2
Genetic Background: C3HeB/FeJ-Pou3f3urehr2

 MP:0003241 loss of cortex neurons "loss of neurons in the cortex region of the brain, commonly due to an apoptotic event" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Pou3f2tm1Tno/Pou3f2tm1Tno,Pou3f3tm1Tno/Pou3f3tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003606 kidney failure "cessation of renal function" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Adamts20bt/Adamts20bt
Genetic Background: DBA

 MP:0003620 decreased urine output "decreased volume of urine produced and excreted" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Adamts20bt/Adamts20bt
Genetic Background: DBA

 MP:0003918 decreased kidney weight "reduced heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Adamts20bt/Adamts20bt
Genetic Background: DBA

Allelic Composition: Pou3f3urehr2/Pou3f3urehr2
Genetic Background: C3HeB/FeJ-Pou3f3urehr2

 MP:0004274 abnormal embryonic/fetal subventricular zone morphology "any structural anomaly in the transient proliferative population of neurons that expands exponentially during late prenatal development; it is a continuous germinal zone distinct from the ventricular zone that surrounds the brain ventricles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
Show

Allelic Composition: Pou3f2tm1Tno/Pou3f2tm1Tno,Pou3f3tm1Tno/Pou3f3tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004467 absent zygomatic bone "absence of the quadrilateral bone that forms the prominence of the cheek" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Apobtm1Unc/Apob+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004755 abnormal loop of Henle "any structural anomaly of the section of the renal tubule in the kidney medulla with a hairpin bend; consists of a descending limb and an ascending limb, and is situated between the proximal convoluted tubule to the distal convoluted tubule; it functions to reabsorb water and ions from the urine" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apobtm1Unc/Apob+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004757 abnormal distal convoluted tubule morphology "any structural anomaly of the convoluted portion of the duct system of the nephron between the ascending portion of the loop of Henle and the collecting duct system in the kidney cortex; it is partly responsible for the regulation of potassium, sodium, calcium, and pH through the endocrine system" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adamts20bt/Adamts20bt
Genetic Background: DBA

 MP:0004899 absent squamosal bone "absence of the thin, plate-like part of the temporal bone" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apobtm1Unc/Apob+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005107 abnormal stapes morphology "structural anomaly of the smallest and innermost of the three auditory ossicles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132]
Show

Allelic Composition: Apobtm1Unc/Apob+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Pou3f3urehr2/Pou3f3urehr2
Genetic Background: C3HeB/FeJ-Pou3f3urehr2

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: UmodUrehd1/Umod+
Genetic Background: C3HeB/FeJ-UmodUrehd1

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Adamts20bt/Adamts20bt
Genetic Background: DBA

Allelic Composition: Pou3f3urehr2/Pou3f3urehr2
Genetic Background: C3HeB/FeJ-Pou3f3urehr2

 MP:0005627 increased circulating potassium level "greater than the normal concentration in the blood of this alkaline metallic element, the most abundant intracellular ion; anomalies in the extracellular (circulating) concentration have important implications for the function of excitable tissues, such as nerve and muscle" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Adamts20bt/Adamts20bt
Genetic Background: DBA

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Pou3f2tm1Tno/Pou3f2tm1Tno,Pou3f3tm1Tno/Pou3f3tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0006317 decreased urine sodium level "lower than normal concentration of sodium in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pou3f3urehr2/Pou3f3urehr2
Genetic Background: C3HeB/FeJ-Pou3f3urehr2

 MP:0008023 abnormal styloid process morphology "any structural abnormality in the slender needle-like pointed projection that runs downward and slightly forward from the base of the inferior surface of the petrous portion of the temporal bone where it joins the tympanic portion; it gives attachment to the styloglossus, stylohyoid, and stylopharyngeus muscles and the stylohyoid and stylomandibular ligaments" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apobtm1Unc/Apob+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008458 abnormal cortical ventricular zone morphology "any structural anomaly of a transient region of the developing cerebral cortex that contains migrating neurons, radial glial cells, and a large population of cycling multipotent neural stem cells that generate newborn neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pou3f2tm1Tno/Pou3f2tm1Tno,Pou3f3tm1Tno/Pou3f3tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0008535 enlarged lateral ventricles "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pou3f2tm1Tno/Pou3f2tm1Tno,Pou3f3tm1Tno/Pou3f3tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0008547 abnormal neocortex morphology "any structural anomaly of the larger part of the mammalian cerebral cortex, distinguished from the allocortex by being composed of a larger number of nerve cells arranged in six layers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.186.211.730.885.213.420]
Show

Allelic Composition: Pou3f2tm1Tno/Pou3f2tm1Tno,Pou3f3tm1Tno/Pou3f3tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Apobtm1Unc/Apob+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Pou3f3tm1Tno/Pou3f3tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Pou3f2tm1Tno/Pou3f2tm1Tno,Pou3f3tm1Tno/Pou3f3tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Pou3f2tm1Rsd/Pou3f2tm1Rsd,Pou3f3tm1Rmc/Pou3f3tm1Rmc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011345 truncated loop of Henle "failure of the developing loop of Henle to elongate and extend into the medullary zone of the kidney" [MGI:anna]
Show

Allelic Composition: Pou3f3tm1Tno/Pou3f3tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0011368 increased kidney apoptosis "increase in the number of cells of the kidney undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Pou3f3tm1Tno/Pou3f3tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0011441 decreased kidney cell proliferation "decrease in the expansion rate of any kidney cell population by cell division" [MGI:anna]
Show

Allelic Composition: Pou3f3tm1Tno/Pou3f3tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0030111 absent temporomandibular joint "absence of the synovial articulation between the head of the mandibular condoyloid process and the mandibular fossa and articular tubercle of the temporal bones" [MGI:anna]
Show

Allelic Composition: Apobtm1Unc/Apob+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0030394 abnormal incus short process morphology "any structural anomaly of the short limb (crus) of the incus that fits into a depression (fossa incudis) in the epitympanic recess; it is attached to the cavity wall by the posterior incudal ligament" [http://audilab.bmed.mcgill.ca/~daren/3Dear/mid1.html, https://medical-dictionary.thefreedictionary.com/short+limb+of+incus]
Show

Allelic Composition: Apobtm1Unc/Apob+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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