ENSMUSG00000032051


Mus musculus

Features
Gene ID: ENSMUSG00000032051
  
Biological name :Fdx1
  
Synonyms : Fdx1 / ferredoxin 1 / P46656
  
Possible biological names infered from orthology : P10109
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A5.3
Gene start: 51943306
Gene end: 51963556
  
Corresponding Affymetrix probe sets: 10593483 (MoGene1.0st)   1449108_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000150434
Ensembl peptide - ENSMUSP00000150644
Ensembl peptide - ENSMUSP00000034552
NCBI entrez gene - 14148     See in Manteia.
MGI - MGI:103224
RefSeq - NM_001301728
RefSeq - NM_007996
RefSeq Peptide - NP_001288657
RefSeq Peptide - NP_032022
swissprot - Q545P3
swissprot - A0A1L1STP5
swissprot - P46656
swissprot - A0A1L1SU91
Ensembl - ENSMUSG00000032051
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fdx1ENSDARG00000056410Danio rerio
 FDX1ENSGALG00000026507Gallus gallus
 FDX1ENSG00000137714Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fdx1l / Q9CPW2 / Ferredoxin-2, mitochondrial / AC011511.1*ENSMUSG0000007967725
AC163637.1 / AC011511.1*ENSMUSG0000011169216


Protein motifs (from Interpro)
Interpro ID Name
 IPR001041  2Fe-2S ferredoxin-type iron-sulfur binding domain
 IPR001055  Adrenodoxin
 IPR012675  Beta-grasp domain superfamily
 IPR018298  Adrenodoxin, iron-sulphur binding site
 IPR036010  2Fe-2S ferredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006694 steroid biosynthetic process IEA
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008203 cholesterol metabolic process ISO
 biological_processGO:0022900 electron transport chain IEA
 biological_processGO:0042446 hormone biosynthetic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0071320 cellular response to cAMP IDA
 biological_processGO:1904322 cellular response to forskolin IDA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005759 mitochondrial matrix ISS
 molecular_functionGO:0009055 electron transfer activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051536 iron-sulfur cluster binding IEA
 molecular_functionGO:0051537 2 iron, 2 sulfur cluster binding IEA


Pathways (from Reactome)
Pathway description
Mitochondrial iron-sulfur cluster biogenesis
Pregnenolone biosynthesis
Endogenous sterols
Electron transport from NADPH to Ferredoxin


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Faddtm1e.1(KOMP)Wtsi/Faddtm1e.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Faddtm1e.1(KOMP)Wtsi/Ucd

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Faddtm1e.1(KOMP)Wtsi/Faddtm1e.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Faddtm1e.1(KOMP)Wtsi/Ucd

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Faddtm1e.1(KOMP)Wtsi/Faddtm1e.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Faddtm1e.1(KOMP)Wtsi/Ucd

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Faddtm1e.1(KOMP)Wtsi/Faddtm1e.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Faddtm1e.1(KOMP)Wtsi/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000018861 Fdxr / Q61578 / ferredoxin reductase / P22570*  / complex / reaction
 ENSMUSG00000032051 Fdx1 / P46656 / ferredoxin 1 / P10109*  / reaction
 ENSMUSG00000032323 Q9QZ82 / Cyp11a1 / Cholesterol side-chain cleavage enzyme, mitochondrial / P05108* / cytochrome P450 family 11 subfamily A member 1*  / complex / reaction






 

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