ENSMUSG00000032420


Mus musculus

Features
Gene ID: ENSMUSG00000032420
  
Biological name :Nt5e
  
Synonyms : 5 nucleotidase, ecto / Nt5e / Q61503
  
Possible biological names infered from orthology : P21589
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: E3.1
Gene start: 88327197
Gene end: 88372092
  
Corresponding Affymetrix probe sets: 10587639 (MoGene1.0st)   1422974_at (Mouse Genome 430 2.0 Array)   1428547_at (Mouse Genome 430 2.0 Array)   1459023_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034992
NCBI entrez gene - 23959     See in Manteia.
MGI - MGI:99782
RefSeq - NM_011851
RefSeq Peptide - NP_035981
swissprot - Q0VEE0
swissprot - Q61503
Ensembl - ENSMUSG00000032420
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nt5eENSDARG00000071017Danio rerio
 ENSGALG00000015833Gallus gallus
 NT5EENSG00000135318Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
4933425L06Rik / RIKEN cDNA 4933425L06 geneENSMUSG0000002171821


Protein motifs (from Interpro)
Interpro ID Name
 IPR004843  Calcineurin-like phosphoesterase domain, ApaH type
 IPR006146  5"-Nucleotidase, conserved site
 IPR006179  5"-Nucleotidase/apyrase
 IPR008334  5"-Nucleotidase, C-terminal
 IPR029052  Metallo-dependent phosphatase-like
 IPR036907  5"-Nucleotidase, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006196 AMP catabolic process IMP
 biological_processGO:0007159 leukocyte cell-cell adhesion IEA
 biological_processGO:0009166 nucleotide catabolic process IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0046086 adenosine biosynthetic process IMP
 biological_processGO:0050728 negative regulation of inflammatory response IMP
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031225 anchored component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0008253 5"-nucleotidase activity ISO
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016788 hydrolase activity, acting on ester bonds IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Nicotinate metabolism
Pyrimidine catabolism
Purine catabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000343 altered response to myocardial infarction "change in the physiological response to necrosis of the cardiac tissue, often resulting from the sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0001357 increased aggression to humans "when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action toward humans" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Webster s II New College Dictionary:ISBN 0-395-70869-9]
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Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Scn8amed-jo2J/Scn8amed-jo2J
Genetic Background: B6(129S7)-Scn8amed-jo2J/J

 MP:0003023 decreased coronary flow rate "reduced rate of blood flow in the blood vessels supplying the heart" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Grm1nmf373/Grm1nmf373
Genetic Background: C57BL/6J-Grm1nmf373/J

 MP:0003037 increased infarction size "increased size of necrotic area from normal of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0003070 increased vascular permeability "greater or faster ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Scn8amed-jo2J/Scn8amed-jo2J
Genetic Background: B6(129S7)-Scn8amed-jo2J/J

Allelic Composition: Nt5etm1Lft/Nt5etm1Lft
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005048 thrombosis "formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Grm1nmf373/Grm1nmf373
Genetic Background: C57BL/6J-Grm1nmf373/J

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0005464 abnormal platelet physiology "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Grm1nmf373/Grm1nmf373
Genetic Background: C57BL/6J-Grm1nmf373/J

 MP:0005529 abnormal renal vascular resistance "deviation from the normal force opposing blood flow in the kidney blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Scn8amed-jo2J/Scn8amed-jo2J
Genetic Background: B6(129S7)-Scn8amed-jo2J/J

 MP:0005607 decreased bleeding time "less than the normal duration of blood flow after skin puncture; indicative of platement and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Grm1nmf373/Grm1nmf373
Genetic Background: C57BL/6J-Grm1nmf373/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000032420 Nt5e / Q61503 / 5 nucleotidase, ecto / P21589*  / complex






 

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