ENSMUSG00000032690


Mus musculus

Features
Gene ID: ENSMUSG00000032690
  
Biological name :Oas2
  
Synonyms : E9Q9A9 / Mus musculus 2-5 oligoadenylate synthetase 2 (Oas2), transcript variant 1, mRNA. / Oas2
  
Possible biological names infered from orthology : 2-5-oligoadenylate synthetase 2 / P29728
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: F
Gene start: 120730333
Gene end: 120749853
  
Corresponding Affymetrix probe sets: 10533198 (MoGene1.0st)   1425065_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000122053
Ensembl peptide - ENSMUSP00000060082
Ensembl peptide - ENSMUSP00000080209
NCBI entrez gene - 246728     See in Manteia.
MGI - MGI:2180852
RefSeq - NM_145227
RefSeq - NM_001347448
RefSeq - XM_006530325
RefSeq Peptide - NP_001334377
RefSeq Peptide - NP_660262
swissprot - F7CFL3
swissprot - E9Q9A9
Ensembl - ENSMUSG00000032690
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 OAS2ENSG00000111335Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Oas3 / Q8VI93 / 2-5-oligoadenylate synthase 3 / Q9Y6K5* / 2-5-oligoadenylate synthetase 3*ENSMUSG0000003266144
Oas1a / P11928 / 2-5-oligoadenylate synthase 1A / OAS1* / P00973* / 2-5-oligoadenylate synthetase 1*ENSMUSG0000005277623
Oas1g / OAS1* / P00973* / 2-5-oligoadenylate synthetase 1*ENSMUSG0000006686123
Oas1f / OAS1* / P00973* / 2-5-oligoadenylate synthetase 1*ENSMUSG0000005376522
Oas1e / Mus musculus 2-5 oligoadenylate synthetase 1E (Oas1e), transcript variant 1, mRNA. / OAS1* / P00973* / 2-5-oligoadenylate synthetase 1*ENSMUSG0000006686720
Oas1c / Q924S2 / Inactive 2-5 oligoadenylate synthetase 1C / OAS1* / P00973* / 2-5-oligoadenylate synthetase 1*ENSMUSG0000000116619
Oas1h / OAS1* / P00973* / 2-5-oligoadenylate synthetase 1*ENSMUSG0000000116819
Oasl2 / Q9Z2F2 / 2-5-oligoadenylate synthase-like protein 2 ENSMUSG0000002956119
Oas1d / Q8VI95 / Inactive 2-5-oligoadenylate synthase 1D / OAS1* / P00973* / 2-5-oligoadenylate synthetase 1*ENSMUSG0000003262319
Oasl1 / Q8VI94 / 2-5-oligoadenylate synthase-like protein 1 / OASL* / Q15646* / 2-5-oligoadenylate synthetase like*ENSMUSG0000004182717
Oas1b / Mus musculus 2-5 oligoadenylate synthetase 1B (Oas1b), transcript variant 1, coding, mRNA. / OAS1* / P00973* / 2-5-oligoadenylate synthetase 1*ENSMUSG0000002960515


Protein motifs (from Interpro)
Interpro ID Name
 IPR002934  Polymerase, nucleotidyl transferase domain
 IPR006116  2-5-oligoadenylate synthetase, N-terminal
 IPR006117  2-5-oligoadenylate synthetase, conserved site
 IPR018952  2"-5"-oligoadenylate synthetase 1, domain 2/C-terminal
 IPR026774  2"-5"-oligoadenylate synthase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006164 purine nucleotide biosynthetic process ISO
 biological_processGO:0006401 RNA catabolic process IDA
 biological_processGO:0006486 protein glycosylation ISO
 biological_processGO:0006955 immune response IEA
 biological_processGO:0009615 response to virus TAS
 biological_processGO:0018377 protein myristoylation ISO
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:0060337 type I interferon signaling pathway IDA
 biological_processGO:1903487 regulation of lactation IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001730 2"-5"-oligoadenylate synthetase activity ISO
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003725 double-stranded RNA binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008270 zinc ion binding ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016779 nucleotidyltransferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001881 abnormal mammary gland physiology "aberrant function of of the milk-secreting gland that lies within the breast" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bag3tm1b(EUCOMM)Hmgu/Bag3tm1b(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6N

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Bag3tm1b(EUCOMM)Hmgu/Bag3tm1b(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6N

 MP:0006270 abnormal mammary gland growth during lactation "anomaly in the final stage of mammary growth that occurs during the start of lactation" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bag3tm1b(EUCOMM)Hmgu/Bag3tm1b(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6N

 MP:0009506 abnormal mammary gland alveolus morphology "any structural anomaly of the sac-like structure of the mammary gland that secretes milk after pregnancy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bag3tm1b(EUCOMM)Hmgu/Bag3tm1b(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6N

 MP:0010174 decreased mammary gland epithelium proliferation "decrease in the expansion rate of the cells of the mammary gland epithelium by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bag3tm1b(EUCOMM)Hmgu/Bag3tm1b(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6N

 MP:0010249 lactation failure "mammary glands do not secrete milk after parturition" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bag3tm1b(EUCOMM)Hmgu/Bag3tm1b(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6N

 MP:0013716 hypolactation "partial failure, or reduced ability to produce or secrete milk from the mammary gland" [MGI:Anna]
Show

Allelic Composition: Bag3tm1b(EUCOMM)Hmgu/Bag3tm1b(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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