ENSMUSG00000032869


Mus musculus

Features
Gene ID: ENSMUSG00000032869
  
Biological name :Psmf1
  
Synonyms : proteasome (prosome, macropain) inhibitor subunit 1 / Psmf1 / Q8BHL8
  
Possible biological names infered from orthology : proteasome inhibitor subunit 1 / Q92530
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: G3
Gene start: 151715812
Gene end: 151744186
  
Corresponding Affymetrix probe sets: 10488575 (MoGene1.0st)   1424369_at (Mouse Genome 430 2.0 Array)   1424370_s_at (Mouse Genome 430 2.0 Array)   1424371_at (Mouse Genome 430 2.0 Array)   1451337_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000105495
Ensembl peptide - ENSMUSP00000117723
Ensembl peptide - ENSMUSP00000041184
NCBI entrez gene - 228769     See in Manteia.
MGI - MGI:1346072
RefSeq - NM_212446
RefSeq - XM_006499306
RefSeq - NM_001305244
RefSeq Peptide - NP_001292173
RefSeq Peptide - NP_997611
swissprot - A2AU35
swissprot - Q8BHL8
swissprot - D6REH2
Ensembl - ENSMUSG00000032869
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 psmf1ENSDARG00000022652Danio rerio
 PSMF1ENSGALG00000000259Gallus gallus
 PSMF1ENSG00000125818Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR013886  PI31 proteasome regulator, C-terminal
 IPR021625  PI31 proteasome regulator, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process ISS
 biological_processGO:1901799 negative regulation of proteasomal protein catabolic process ISS
 cellular_componentGO:0000502 proteasome complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISO
 molecular_functionGO:0042803 protein homodimerization activity ISO
 molecular_functionGO:0046982 protein heterodimerization activity ISO
 molecular_functionGO:0070628 proteasome binding ISS


Pathways (from Reactome)
Pathway description
AUF1 (hnRNP D0) binds and destabilizes mRNA
ABC-family proteins mediated transport
Antigen processing: Ubiquitination & Proteasome degradation
Activation of NF-kappaB in B cells
Asymmetric localization of PCP proteins
CDK-mediated phosphorylation and removal of Cdc6
CLEC7A (Dectin-1) signaling
Degradation of DVL
Degradation of GLI1 by the proteasome
Cross-presentation of soluble exogenous antigens (endosomes)
Degradation of beta-catenin by the destruction complex
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Downstream TCR signaling
GLI3 is processed to GLI3R by the proteasome
Hedgehog on state
Interleukin-1 signaling
MAPK6/MAPK4 signaling
Neddylation
Orc1 removal from chromatin
Regulation of PTEN stability and activity
Regulation of ornithine decarboxylase (ODC)
Regulation of RUNX2 expression and activity
Regulation of RAS by GAPs
SCF(Skp2)-mediated degradation of p27/p21
Regulation of RUNX3 expression and activity
TNFR2 non-canonical NF-kB pathway
Ub-specific processing proteases
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
UCH proteinases
Ubiquitin-dependent degradation of Cyclin D1
Separation of Sister Chromatids
NIK-->noncanonical NF-kB signaling
APC/C:Cdc20 mediated degradation of Securin
Autodegradation of the E3 ubiquitin ligase COP1
SCF-beta-TrCP mediated degradation of Emi1
Autodegradation of Cdh1 by Cdh1:APC/C
CDT1 association with the CDC6:ORC:origin complex
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
FCERI mediated NF-kB activation
Hedgehog ligand biogenesis
The role of GTSE1 in G2/M progression after G2 checkpoint
G2/M Checkpoints
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Dectin-1 mediated noncanonical NF-kB signaling
Degradation of AXIN
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Psen1tm1.1(KOMP)Vlcg/Psen1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psen1tm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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