ENSMUSG00000032978


Mus musculus

Features
Gene ID: ENSMUSG00000032978
  
Biological name :Guca2b
  
Synonyms : Guanylate cyclase activator 2B Uroguanylin / Guca2b / O09051
  
Possible biological names infered from orthology : guanylate cyclase activator 2B / Q16661
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D2.1
Gene start: 119656607
Gene end: 119658954
  
Corresponding Affymetrix probe sets: 10515935 (MoGene1.0st)   1460233_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000101916
Ensembl peptide - ENSMUSP00000043203
NCBI entrez gene - 14916     See in Manteia.
MGI - MGI:1270851
RefSeq - NM_008191
RefSeq Peptide - NP_032217
swissprot - A2AA35
swissprot - O09051
swissprot - Q9QUQ3
Ensembl - ENSMUSG00000032978
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GUCA2BENSG00000044012Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000879  Guanylin
 IPR036382  Guanylin superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006182 cGMP biosynthetic process IMP
 biological_processGO:0007588 excretion IMP
 biological_processGO:0007589 body fluid secretion IMP
 biological_processGO:0030802 obsolete regulation of cyclic nucleotide biosynthetic process IEA
 biological_processGO:0031284 positive regulation of guanylate cyclase activity IEA
 biological_processGO:0045776 negative regulation of blood pressure IMP
 cellular_componentGO:0001750 photoreceptor outer segment IDA
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0030250 guanylate cyclase activator activity IEA


Pathways (from Reactome)
Pathway description
Digestion


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002136 abnormal kidney physiology "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hba-a1tm1Ywk/Hba-a1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0004216 salt-resistant hypertension "sustained high blood pressure that is maintained regardless of the amount of salt consumed in the diet" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hba-a1tm1Ywk/Hba-a1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0005556 abnormal kidney clearance "altered ability of the kidneys to remove substances from the plasma for excretion in a specific period of time" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hba-a1tm1Ywk/Hba-a1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0005618 decreased potassium excretion "less than the normal amount of this alkaline metallic element, the most abundant intracellular ion, voided by the kidneys" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Hba-a1tm1Ywk/Hba-a1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0005633 increased circulating sodium level "greater than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Hba-a1tm1Ywk/Hba-a1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0006317 decreased urine sodium level "lower than normal concentration of sodium in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hba-a1tm1Ywk/Hba-a1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0008864 abnormal intestinal secretion "any anomaly in the quantity or rate of any substance transported from intestinal cells into the lumen of the intestine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hba-a1tm1Ywk/Hba-a1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hba-a1tm1Ywk/Hba-a1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000042638 Gucy2c / Q3UWA6 / Heat-stable enterotoxin receptor / P25092* / guanylate cyclase 2C*  / complex / reaction






 

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