ENSMUSG00000042638


Mus musculus

Features
Gene ID: ENSMUSG00000042638
  
Biological name :Gucy2c
  
Synonyms : Gucy2c / Heat-stable enterotoxin receptor / Q3UWA6
  
Possible biological names infered from orthology : guanylate cyclase 2C / P25092
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: G1
Gene start: 136697284
Gene end: 136781765
  
Corresponding Affymetrix probe sets: 10548829 (MoGene1.0st)   1436370_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000032338
Ensembl peptide - ENSMUSP00000077236
NCBI entrez gene - 14917     See in Manteia.
MGI - MGI:106903
RefSeq - NM_001127318
RefSeq - NM_145067
RefSeq Peptide - NP_001120790
RefSeq Peptide - NP_659504
swissprot - Q3UWA6
Ensembl - ENSMUSG00000042638
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gucy2cENSDARG00000014320Danio rerio
 si:ch73-139e5.4ENSDARG00000056045Danio rerio
 GUCY2CENSGALG00000011838Gallus gallus
 GUCY2CENSG00000070019Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gucy2e / P52785 / Guanylyl cyclase GC-E / GUCY2D* / Q02846* / guanylate cyclase 2D, retinal*ENSMUSG0000002089030
Gucy2f / Q5SDA5 / Retinal guanylyl cyclase 2 / P51841* / guanylate cyclase 2F, retinal*ENSMUSG0000004228230
Npr1 / P18293 / natriuretic peptide receptor 1 / P16066*ENSMUSG0000002793129
Npr2 / Q6VVW5 / natriuretic peptide receptor 2 / P20594*ENSMUSG0000002846929
Gucy2dENSMUSG0000007400329
Gucy2g / Q6TL19 / Guanylate cyclase 2G ENSMUSG0000005552325
Gucy1b2ENSMUSG0000002193315
Q9ERL9 / Gucy1a1 / guanylate cyclase 1, soluble, alpha 1 / Q02108* / guanylate cyclase 1 soluble subunit alpha 1*ENSMUSG0000003391014
Gucy1a2 / guanylate cyclase 1 soluble subunit alpha 2 / P33402*ENSMUSG0000004162414
O54865 / Gucy1b1 / guanylate cyclase 1, soluble, beta 1 / Q02153* / guanylate cyclase 1 soluble subunit beta 1*ENSMUSG0000002800512


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001054  Adenylyl cyclase class-3/4/guanylyl cyclase
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001828  Receptor, ligand binding region
 IPR011009  Protein kinase-like domain superfamily
 IPR018297  Adenylyl cyclase class-4/guanylyl cyclase, conserved site
 IPR028082  Periplasmic binding protein-like I
 IPR029787  Nucleotide cyclase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006182 cGMP biosynthetic process IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0009190 cyclic nucleotide biosynthetic process IEA
 biological_processGO:0009636 response to toxic substance IMP
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0042127 regulation of cell proliferation IGI
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0008074 guanylate cyclase complex, soluble IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004383 guanylate cyclase activity IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0015643 toxic substance binding IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0016849 phosphorus-oxygen lyase activity IEA


Pathways (from Reactome)
Pathway description
Digestion


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Myo5ad/Myo5ad-97H
Genetic Background: involves: 101/H * C3H/HeH

 MP:0001433 polyphagia "eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myo5ad/Myo5ad-97H
Genetic Background: involves: 101/H * C3H/HeH

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Myo5ad/Myo5ad-97H
Genetic Background: involves: 101/H * C3H/HeH

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Myo5ad/Myo5ad-97H
Genetic Background: involves: 101/H * C3H/HeH

 MP:0002409 decreased susceptibility to infection "reduced likelihood that an organism will develop ill effects from a pathogenic invasion or from components of or toxins produced by pathogens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Kcne12J/Kcne12J
Genetic Background: C57BL/6J-Kcne12J/J

 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pou3f1tm1Rsd/Pou3f1tm1Rsd
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6J

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myo5ad/Myo5ad-97H
Genetic Background: involves: 101/H * C3H/HeH

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Myo5ad/Myo5ad-97H
Genetic Background: involves: 101/H * C3H/HeH

 MP:0005036 diarrhea "abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pou3f1tm1Rsd/Pou3f1tm1Rsd
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6J

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Myo5ad/Myo5ad-97H
Genetic Background: involves: 101/H * C3H/HeH

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Myo5ad/Myo5ad-97H
Genetic Background: involves: 101/H * C3H/HeH

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myo5ad/Myo5ad-97H
Genetic Background: involves: 101/H * C3H/HeH

 MP:0009789 decreased susceptibility to bacterial infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pou3f1tm1Rsd/Pou3f1tm1Rsd
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6J

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myo5ad/Myo5ad-97H
Genetic Background: involves: 101/H * C3H/HeH

 MP:0010934 increased subcutaneous adipose tissue amount "increase in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myo5ad/Myo5ad-97H
Genetic Background: involves: 101/H * C3H/HeH

 MP:0011958 increased compensatory feeding amount "increased amount of food consumed after a period of fasting" [MGI:csmith]
Show

Allelic Composition: Myo5ad/Myo5ad-97H
Genetic Background: involves: 101/H * C3H/HeH

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000023247 Guca2a / P33680 / Guanylin / Q02747* / guanylate cyclase activator 2A*  / complex / reaction
 ENSMUSG00000042638 Gucy2c / Q3UWA6 / Heat-stable enterotoxin receptor / P25092* / guanylate cyclase 2C*  / complex
 ENSMUSG00000032978 Guca2b / O09051 / Guanylate cyclase activator 2B Uroguanylin / Q16661* / guanylate cyclase activator 2B*  / complex / reaction






 

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