ENSMUSG00000020890


Mus musculus

Features
Gene ID: ENSMUSG00000020890
  
Biological name :Gucy2e
  
Synonyms : Guanylyl cyclase GC-E / Gucy2e / P52785
  
Possible biological names infered from orthology : guanylate cyclase 2D, retinal / GUCY2D / Q02846
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B3
Gene start: 69218117
Gene end: 69237036
  
Corresponding Affymetrix probe sets: 10387274 (MoGene1.0st)   1422193_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021259
Ensembl peptide - ENSMUSP00000104304
Ensembl peptide - ENSMUSP00000104305
NCBI entrez gene - 14919     See in Manteia.
MGI - MGI:105123
RefSeq - NM_008192
RefSeq - XM_006532244
RefSeq Peptide - NP_032218
swissprot - P52785
Ensembl - ENSMUSG00000020890
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gucy2dENSDARG00000026820Danio rerio
 ENSGALG00000000808Gallus gallus
 GUCY2DENSG00000132518Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gucy2f / Q5SDA5 / Retinal guanylyl cyclase 2 / P51841* / guanylate cyclase 2F, retinal*ENSMUSG0000004228251
Gucy2dENSMUSG0000007400349
Npr2 / Q6VVW5 / natriuretic peptide receptor 2 / P20594*ENSMUSG0000002846931
Npr1 / P18293 / natriuretic peptide receptor 1 / P16066*ENSMUSG0000002793130
Gucy2c / Q3UWA6 / Heat-stable enterotoxin receptor / P25092* / guanylate cyclase 2C*ENSMUSG0000004263829
Gucy2g / Q6TL19 / Guanylate cyclase 2G ENSMUSG0000005552329
Gucy1b2ENSMUSG0000002193316
Q9ERL9 / Gucy1a1 / guanylate cyclase 1, soluble, alpha 1 / Q02108* / guanylate cyclase 1 soluble subunit alpha 1*ENSMUSG0000003391015
Gucy1a2 / guanylate cyclase 1 soluble subunit alpha 2 / P33402*ENSMUSG0000004162415
O54865 / Gucy1b1 / guanylate cyclase 1, soluble, beta 1 / Q02153* / guanylate cyclase 1 soluble subunit beta 1*ENSMUSG0000002800513


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001054  Adenylyl cyclase class-3/4/guanylyl cyclase
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001828  Receptor, ligand binding region
 IPR011009  Protein kinase-like domain superfamily
 IPR011645  Haem NO binding associated
 IPR018297  Adenylyl cyclase class-4/guanylyl cyclase, conserved site
 IPR028082  Periplasmic binding protein-like I
 IPR029787  Nucleotide cyclase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006182 cGMP biosynthetic process IBA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0007601 visual perception IEA
 biological_processGO:0009190 cyclic nucleotide biosynthetic process IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0050896 response to stimulus IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0008074 guanylate cyclase complex, soluble IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004383 guanylate cyclase activity IBA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0016849 phosphorus-oxygen lyase activity IEA


Pathways (from Reactome)
Pathway description
Inactivation, recovery and regulation of the phototransduction cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001005 abnormal rod morphology "structural or developmental anomaly of the photoreceptors that contain rhodopsin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gucy2etm1Gar/Gucy2etm1Gar
Genetic Background: involves: 129S6/SvEvTac

 MP:0001006 abnormal cone morphology "structural or developmental anomaly of the retinal receptors that give rise to color vision" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Myo6sv-3J/Myo6sv-3J
Genetic Background: C57BL/6J-Myo6sv-3J

 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Myo6sv-3J/Myo6sv-3J
Genetic Background: C57BL/6J-Myo6sv-3J

 MP:0004021 abnormal rod electrophysiology "anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Gucy2etm1Gar/Gucy2etm1Gar
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Gucy2etm1Gar/Gucy2etm1Gar,Gucy2ftm1Wbae/Gucy2ftm1Wbae
Genetic Background: involves: 129S6/SvEvTac

 MP:0004022 abnormal cone electrophysiology "anomaly in the function of light adapted vision mediated by the cones" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005253 abnormal eye physiology "anomalous function and/or activity of the ocular system or any of its parts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Myo6sv-3J/Myo6sv-3J
Genetic Background: C57BL/6J-Myo6sv-3J

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Gucy2etm1Gar/Gucy2etm1Gar
Genetic Background: involves: 129S6/SvEvTac

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tex19.1tm2.2Ics/Tex19.1tm2.2Ics,Tex19.2tm1.2Ics/Tex19.2tm1.2Ics
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0008444 retinal cone cell degeneration "a retrogressive impairment of function or destruction of one of the photoreceptor cell types in the retina, in which the photopigment is in invaginations of the cell membrane of the outer segment" [MESH:A08.663.650.650.670.100, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Gucy2etm1Gar/Gucy2etm1Gar,Gucy2ftm1Wbae/Gucy2ftm1Wbae
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Gucy2etm1Gar/Gucy2etm1Gar,Nrltm1Asw/Nrltm1Asw
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0008446 decreased retinal cone cell number "reduced number of one of the photoreceptor cell types in the retina, in which the photopigment is in invaginations of the cell membrane of the outer segment" [MESH:A08.663.650.650.670.100, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Gucy2etm1Gar/Gucy2etm1Gar,Gucy2ftm1Wbae/Gucy2ftm1Wbae
Genetic Background: involves: 129S6/SvEvTac

 MP:0008448 abnormal retinal cone cell inner segment morphology "any structural anomaly of the retinal cone cell region which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc) and where opsin molecules are assembled and passed to be part of the outer segment region" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gucy2etm1Gar/Gucy2etm1Gar
Genetic Background: involves: 129S6/SvEvTac

 MP:0008449 abnormal retinal cone cell outer segment morphology "any structural anomaly of the retinal cone cell region in which the visual pigment rhodopsin is in invaginations of the cell membrane" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gucy2etm1Gar/Gucy2etm1Gar
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Gucy2etm1Gar/Gucy2etm1Gar,Gucy2ftm1Wbae/Gucy2ftm1Wbae
Genetic Background: involves: 129S6/SvEvTac

 MP:0008456 abnormal retinal rod cell outer segment morphology "any strucutral anomaly of the retinal rod cell region which contains stacks of membranous discs separate from the outer cell membrane that are rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gucy2etm1Gar/Gucy2etm1Gar,Gucy2ftm1Wbae/Gucy2ftm1Wbae
Genetic Background: involves: 129S6/SvEvTac

 MP:0008515 thin retinal outer nuclear layer "reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gucy2etm1Gar/Gucy2etm1Gar,Gucy2ftm1Wbae/Gucy2ftm1Wbae
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Gucy2etm1Gar/Gucy2etm1Gar,Nrltm1Asw/Nrltm1Asw
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0008587 short photoreceptor outer segment "decreased length of the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gucy2etm1Gar/Gucy2etm1Gar,Gucy2ftm1Wbae/Gucy2ftm1Wbae
Genetic Background: involves: 129S6/SvEvTac

 MP:0009619 abnormal optokinetic reflex "any anomaly in the nystagmus or deviation of the eyes in response to stimulation of the visual system by movement; normally, this reflex functions to stabilize a moving image on the retina" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gucy2etm1Gar/Gucy2etm1Gar,Nrltm1Asw/Nrltm1Asw
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0012029 abnormal electroretinogram waveform feature "any anomaly in the pattern of the graphic record of the integrated ensemble response from many vision related neuronal and glial populations as a consequence of the serial processing within the retina, represented as changes in voltage over time after visual photonic stimulation" [MGI:csmith]
Show

Allelic Composition: Gucy2etm1Gar/Gucy2etm1Gar,Nrltm1Asw/Nrltm1Asw
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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