ENSMUSG00000042282


Mus musculus

Features
Gene ID: ENSMUSG00000042282
  
Biological name :Gucy2f
  
Synonyms : Gucy2f / Q5SDA5 / Retinal guanylyl cyclase 2
  
Possible biological names infered from orthology : guanylate cyclase 2F, retinal / P51841
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: F2
Gene start: 142081160
Gene end: 142196931
  
Corresponding Affymetrix probe sets: 10607064 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000044521
NCBI entrez gene - 245650     See in Manteia.
MGI - MGI:105119
RefSeq - NM_001007576
RefSeq - XM_006528841
RefSeq Peptide - NP_001007577
swissprot - Q5SDA5
Ensembl - ENSMUSG00000042282
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gc2ENSDARG00000018329Danio rerio
 ENSGALG00000000808Gallus gallus
 GUCY2FENSG00000101890Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gucy2e / P52785 / Guanylyl cyclase GC-E / GUCY2D* / Q02846* / guanylate cyclase 2D, retinal*ENSMUSG0000002089051
Gucy2dENSMUSG0000007400349
Npr2 / Q6VVW5 / natriuretic peptide receptor 2 / P20594*ENSMUSG0000002846932
Npr1 / P18293 / natriuretic peptide receptor 1 / P16066*ENSMUSG0000002793131
Gucy2g / Q6TL19 / Guanylate cyclase 2G ENSMUSG0000005552330
Gucy2c / Q3UWA6 / Heat-stable enterotoxin receptor / P25092* / guanylate cyclase 2C*ENSMUSG0000004263829
Gucy1b2ENSMUSG0000002193316
Gucy1a2 / guanylate cyclase 1 soluble subunit alpha 2 / P33402*ENSMUSG0000004162416
Q9ERL9 / Gucy1a1 / guanylate cyclase 1, soluble, alpha 1 / Q02108* / guanylate cyclase 1 soluble subunit alpha 1*ENSMUSG0000003391014
O54865 / Gucy1b1 / guanylate cyclase 1, soluble, beta 1 / Q02153* / guanylate cyclase 1 soluble subunit beta 1*ENSMUSG0000002800513


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001054  Adenylyl cyclase class-3/4/guanylyl cyclase
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001828  Receptor, ligand binding region
 IPR011009  Protein kinase-like domain superfamily
 IPR018297  Adenylyl cyclase class-4/guanylyl cyclase, conserved site
 IPR028082  Periplasmic binding protein-like I
 IPR029787  Nucleotide cyclase
 IPR033484  Retinal guanylyl cyclase 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006182 cGMP biosynthetic process IBA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0007601 visual perception IEA
 biological_processGO:0009190 cyclic nucleotide biosynthetic process IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0050896 response to stimulus IEA
 biological_processGO:0050908 detection of light stimulus involved in visual perception IMP
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0008074 guanylate cyclase complex, soluble IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004383 guanylate cyclase activity IBA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0016849 phosphorus-oxygen lyase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Inactivation, recovery and regulation of the phototransduction cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001005 abnormal rod morphology "structural or developmental anomaly of the photoreceptors that contain rhodopsin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gucy2etm1Gar/Gucy2etm1Gar
Genetic Background: involves: 129S6/SvEvTac

 MP:0004021 abnormal rod electrophysiology "anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gucy2etm1Gar/Gucy2etm1Gar
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Gucy2etm1Gar/Gucy2etm1Gar,Gucy2ftm1Wbae/Gucy2ftm1Wbae
Genetic Background: involves: 129S6/SvEvTac

 MP:0008444 retinal cone cell degeneration "a retrogressive impairment of function or destruction of one of the photoreceptor cell types in the retina, in which the photopigment is in invaginations of the cell membrane of the outer segment" [MESH:A08.663.650.650.670.100, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gucy2etm1Gar/Gucy2etm1Gar,Gucy2ftm1Wbae/Gucy2ftm1Wbae
Genetic Background: involves: 129S6/SvEvTac

 MP:0008446 decreased retinal cone cell number "reduced number of one of the photoreceptor cell types in the retina, in which the photopigment is in invaginations of the cell membrane of the outer segment" [MESH:A08.663.650.650.670.100, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gucy2etm1Gar/Gucy2etm1Gar,Gucy2ftm1Wbae/Gucy2ftm1Wbae
Genetic Background: involves: 129S6/SvEvTac

 MP:0008449 abnormal retinal cone cell outer segment morphology "any structural anomaly of the retinal cone cell region in which the visual pigment rhodopsin is in invaginations of the cell membrane" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gucy2etm1Gar/Gucy2etm1Gar,Gucy2ftm1Wbae/Gucy2ftm1Wbae
Genetic Background: involves: 129S6/SvEvTac

 MP:0008456 abnormal retinal rod cell outer segment morphology "any strucutral anomaly of the retinal rod cell region which contains stacks of membranous discs separate from the outer cell membrane that are rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gucy2etm1Gar/Gucy2etm1Gar,Gucy2ftm1Wbae/Gucy2ftm1Wbae
Genetic Background: involves: 129S6/SvEvTac

 MP:0008515 thin retinal outer nuclear layer "reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gucy2etm1Gar/Gucy2etm1Gar,Gucy2ftm1Wbae/Gucy2ftm1Wbae
Genetic Background: involves: 129S6/SvEvTac

 MP:0008587 short photoreceptor outer segment "decreased length of the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gucy2etm1Gar/Gucy2etm1Gar,Gucy2ftm1Wbae/Gucy2ftm1Wbae
Genetic Background: involves: 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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