ENSMUSG00000074003


Mus musculus
cyclaseGucy2dproteinbindingactivitykinasedomainnucleotidemembraneolfactoryadenylylclass-guanylylbiosyntheticprocesssignaltransductionintracellularguanylatelyasebulbserine-threoninetyrosine-proteincatalyticreceptorligandregionkinase-likesuperfamilyconservedsite

Features
Gene ID: ENSMUSG00000074003
  
Biological name :Gucy2d
  
Synonyms : Gucy2d
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: E1
Gene start: 98440416
Gene end: 98477479
  
Corresponding Affymetrix probe sets: 10555156 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000095875
Ensembl peptide - ENSMUSP00000146093
Ensembl peptide - ENSMUSP00000145913
NCBI entrez gene - 14918     See in Manteia.
MGI - MGI:106030
RefSeq - NM_001130693
RefSeq - XM_011241678
RefSeq Peptide - NP_001124165
swissprot - A0A0U1RPB5
swissprot - F6VFS9
swissprot - A0A0U1RPR8
Ensembl - ENSMUSG00000074003
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
No match


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gucy2e / P52785 / Guanylyl cyclase GC-E / GUCY2D* / Q02846* / guanylate cyclase 2D, retinal*ENSMUSG0000002089049
Gucy2f / Q5SDA5 / Retinal guanylyl cyclase 2 / P51841* / guanylate cyclase 2F, retinal*ENSMUSG0000004228249
Npr2 / Q6VVW5 / natriuretic peptide receptor 2 / P20594*ENSMUSG0000002846930
Npr1 / P18293 / natriuretic peptide receptor 1 / P16066*ENSMUSG0000002793129
Gucy2g / Q6TL19 / Guanylate cyclase 2G ENSMUSG0000005552329
Gucy2c / Q3UWA6 / Heat-stable enterotoxin receptor / P25092* / guanylate cyclase 2C*ENSMUSG0000004263828
Gucy1b2ENSMUSG0000002193316
Q9ERL9 / Gucy1a1 / guanylate cyclase 1, soluble, alpha 1 / Q02108* / guanylate cyclase 1 soluble subunit alpha 1*ENSMUSG0000003391015
Gucy1a2 / guanylate cyclase 1 soluble subunit alpha 2 / P33402*ENSMUSG0000004162415
O54865 / Gucy1b1 / guanylate cyclase 1, soluble, beta 1 / Q02153* / guanylate cyclase 1 soluble subunit beta 1*ENSMUSG0000002800513


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001054  Adenylyl cyclase class-3/4/guanylyl cyclase
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001828  Receptor, ligand binding region
 IPR011009  Protein kinase-like domain superfamily
 IPR018297  Adenylyl cyclase class-4/guanylyl cyclase, conserved site
 IPR028082  Periplasmic binding protein-like I
 IPR029787  Nucleotide cyclase


Gene Ontology (GO)
nitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processcell communicationcellular response to stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processcell communicationcellular response to stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processcell communicationcellular response to stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processcell communicationcellular response to stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processcell communicationcellular response to stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processcell communicationcellular response to stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processcell communicationcellular response to stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processcell communicationcellular response to stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processcell communicationcellular response to stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processcell communicationcellular response to stimulusnitrogen compoundnitrogen compound metabolic processbiosynthetic procbiosynthetic processcellular metabolicellular metabolic processprimary metabolicprimary metabolic processsmall molecule mesmall molecule metabolic processorganic substanceorganic substance metabolic processcell communicatiocell communicationcellular responsecellular response to stimulus
organic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcyclase activitylyase activitycatalytic activity, acting on a proteintransferase activityion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcyclase activitylyase activitycatalytic activity, acting on a proteintransferase activityion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcyclase activitylyase activitycatalytic activity, acting on a proteintransferase activityion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcyclase activitylyase activitycatalytic activity, acting on a proteintransferase activityion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcyclase activitylyase activitycatalytic activity, acting on a proteintransferase activityion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcyclase activitylyase activitycatalytic activity, acting on a proteintransferase activityion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcyclase activitylyase activitycatalytic activity, acting on a proteintransferase activityion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcyclase activitylyase activitycatalytic activity, acting on a proteintransferase activityion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcyclase activitylyase activitycatalytic activity, acting on a proteintransferase activityion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcyclase activitylyase activitycatalytic activity, acting on a proteintransferase activityion bindingcarbohydrate derivative bindingdrug bindingorganic cyclicorganic cyclic compound bindingheterocyclic cheterocyclic compound bindingsmall moleculesmall molecule bindingcyclase activicyclase activitylyase activitylyase activitycatalytic acticatalytic activity, acting on a proteintransferase actransferase activityion bindingion bindingcarbohydrate dcarbohydrate derivative bindingdrug bindingdrug binding
cellmembraneprotein-containing complexcellmembraneprotein-containing complexcellmembraneprotein-containing complexcellmembraneprotein-containing complexcellmembraneprotein-containing complexcellmembraneprotein-containing complexcellmembraneprotein-containing complexcellmembraneprotein-containing complexcellmembraneprotein-containing complexcellmembraneprotein-containing complexcellcellmembranemembraneprotein-containing complexprotein-containing complex
TypeGO IDTermEv.Code
 biological_processGO:0006182 cGMP biosynthetic process IBA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0009190 cyclic nucleotide biosynthetic process IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0008074 guanylate cyclase complex, soluble IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004383 guanylate cyclase activity IBA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0016849 phosphorus-oxygen lyase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
nervous system phenotypetaste/olfaction phenotypenervous system phenotypetaste/olfaction phenotypenervous system phenotypetaste/olfaction phenotypenervous system phenotypetaste/olfaction phenotypenervous system phenotypetaste/olfaction phenotypenervous system phenotypetaste/olfaction phenotypenervous system phenotypetaste/olfaction phenotypenervous system phenotypetaste/olfaction phenotypenervous system phenotypetaste/olfaction phenotypenervous system phenotypetaste/olfaction phenotypenervous system phenotypenervous system phenotypetaste/olfaction phenotypetaste/olfaction phenotype
IDPhenotypeDefinition Genetic BG
 MP:0000819 abnormal olfactory bulb morphology "malformation or absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:16461]
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Allelic Composition: Ednrbs-15DttMb/Ednrbs-15DttMb
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/6J

Allelic Composition: Gucy2dtm1Mom/Gucy2dtm1Mom,Sema3ftm1Mom/Sema3ftm1Mom
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001983 abnormal olfactory system physiology "abnormal function of the system relating to smell " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ltbp3m1Btlr/Ltbp3m1Btlr
Genetic Background: either: C57BL/6J-Ltbp3m1Btlr or (involves: C3H/HeJ * C57BL/6J)

 MP:0009943 abnormal olfactory bulb periglomerular cell morphology "any structural anomaly of the small neuron in the glomerular layer of the olfactory bulb whose dendrites arborize within a glomerulus, where it receives synaptic input from olfactory receptor cell axon terminals, and also engages in dendrodendritic interactions with mitral and tufted cell dendrites; uses both GABA and dopamine as a neurotransmitter" [NLX:nlx_cell_091202 "NeuroLex.org"]
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Allelic Composition: Ltbp3m1Btlr/Ltbp3m1Btlr
Genetic Background: either: C57BL/6J-Ltbp3m1Btlr or (involves: C3H/HeJ * C57BL/6J)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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