ENSMUSG00000033569


Mus musculus

Features
Gene ID: ENSMUSG00000033569
  
Biological name :Adgrb3
  
Synonyms : Adgrb3 / Adhesion G protein-coupled receptor B3 / Q80ZF8
  
Possible biological names infered from orthology : O60242
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: A5
Gene start: 25067476
Gene end: 25829707
  
Corresponding Affymetrix probe sets: 10353632 (MoGene1.0st)   1454782_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116231
Ensembl peptide - ENSMUSP00000116759
Ensembl peptide - ENSMUSP00000119804
Ensembl peptide - ENSMUSP00000115442
Ensembl peptide - ENSMUSP00000035612
NCBI entrez gene - 210933     See in Manteia.
MGI - MGI:2441837
RefSeq - XM_017319555
RefSeq - NM_175642
RefSeq - XM_006495817
RefSeq - XM_006495818
RefSeq Peptide - NP_783573
swissprot - Q8BJ13
swissprot - Q68FL1
swissprot - Q80ZF8
Ensembl - ENSMUSG00000033569
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adgrb3ENSDARG00000059832Danio rerio
 ENSGALG00000044704Gallus gallus
 ENSGALG00000030872Gallus gallus
 ENSGALG00000016176Gallus gallus
 ADGRB3ENSG00000135298Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Adgrb2 / Q8CGM1 / Adhesion G protein-coupled receptor B2 / O60241*ENSMUSG0000002878250
Adgrb1 / Q3UHD1 / Adhesion G protein-coupled receptor B1 Vasculostatin-120 Vasculostatin-40 / O14514* / adhesion G protein-coupled receptor B1*ENSMUSG0000003473049
Adgrf5 / G5E8Q8 / Mus musculus adhesion G protein-coupled receptor F5 (Adgrf5), transcript variant 2, mRNA. / Q8IZF2* / adhesion G protein-coupled receptor F5*ENSMUSG0000005649213
Adgrf1 / Q8VEC3 / Adhesion G-protein coupled receptor F1 / Q5T601*ENSMUSG0000004129311
Adgrf3 / Q58Y75 / Adhesion G-protein coupled receptor F3 / Q8IZF5*ENSMUSG0000006764211
Cfp / P11680 / complement factor properdin / P27918*ENSMUSG000000011289
Adgrf4 / adhesion G protein-coupled receptor F4 / Q8IZF3*ENSMUSG000000239188
Adgrf2 / E9Q4J9 / Adhesion G-protein coupled receptor F2 / Q8IZF7*ENSMUSG000000578998


Protein motifs (from Interpro)
Interpro ID Name
 IPR000203  GPS motif
 IPR000832  GPCR, family 2, secretin-like
 IPR000884  Thrombospondin type-1 (TSP1) repeat
 IPR001879  GPCR, family 2, extracellular hormone receptor domain
 IPR008077  GPCR, family 2, brain-specific angiogenesis inhibitor
 IPR017981  GPCR, family 2-like
 IPR017983  GPCR, family 2, secretin-like, conserved site
 IPR032471  GAIN domain, N-terminal
 IPR036383  Thrombospondin type-1 (TSP1) repeat superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007520 myoblast fusion ISS
 biological_processGO:0016322 neuron remodeling IGI
 biological_processGO:0016525 negative regulation of angiogenesis IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0048814 regulation of dendrite morphogenesis IMP
 biological_processGO:0051965 positive regulation of synapse assembly IDA
 biological_processGO:0061743 motor learning IGI
 biological_processGO:0099558 maintenance of synapse structure IMP
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043083 synaptic cleft IDA
 cellular_componentGO:0098794 postsynapse IDA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0005096 GTPase activator activity IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001899 absent long term depression "lack of the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [Principles of Neural Science:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kcnt1tm1.1Acsc/Kcnt1tm1.1Acsc,Tg(Scn10a-cre)1Rkun/0
Genetic Background: involves: BALB/cJ * C57BL/6 * C57BL/6N * DBA/2

 MP:0002804 abnormal motor learning "defects in the ability to repeat a motor task requiring well coordinated movements and balance; measures cerebellar dependent learning" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Kcnt1tm1.1Acsc/Kcnt1tm1.1Acsc,Tg(Scn10a-cre)1Rkun/0
Genetic Background: involves: BALB/cJ * C57BL/6 * C57BL/6N * DBA/2

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Kcnt1tm1.1Acsc/Kcnt1tm1.1Acsc,Tg(Scn10a-cre)1Rkun/0
Genetic Background: involves: BALB/cJ * C57BL/6 * C57BL/6N * DBA/2

 MP:0003412 abnormal afterhyperpolarization "anomaly in the currents that follow an action potential and influence firing frequency and neuronal integration" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94941]
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Allelic Composition: Kcnt1tm1.1Acsc/Kcnt1tm1.1Acsc,Tg(Scn10a-cre)1Rkun/0
Genetic Background: involves: BALB/cJ * C57BL/6 * C57BL/6N * DBA/2

 MP:0003463 abnormal single cell response "altered values from controls obtained upon extra- or intracellular recordings from single cells" [Nmice:Neuromice Consortium Submission]
Show

Allelic Composition: Kcnt1tm1.1Acsc/Kcnt1tm1.1Acsc,Tg(Scn10a-cre)1Rkun/0
Genetic Background: involves: BALB/cJ * C57BL/6 * C57BL/6N * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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