ENSMUSG00000056492


Mus musculus

Features
Gene ID: ENSMUSG00000056492
  
Biological name :Adgrf5
  
Synonyms : Adgrf5 / G5E8Q8 / Mus musculus adhesion G protein-coupled receptor F5 (Adgrf5), transcript variant 2, mRNA.
  
Possible biological names infered from orthology : adhesion G protein-coupled receptor F5 / Q8IZF2
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: B3
Gene start: 43360451
Gene end: 43459557
  
Corresponding Affymetrix probe sets: 10445268 (MoGene1.0st)   1440225_at (Mouse Genome 430 2.0 Array)   1440830_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000153373
Ensembl peptide - ENSMUSP00000152923
Ensembl peptide - ENSMUSP00000153704
Ensembl peptide - ENSMUSP00000153049
Ensembl peptide - ENSMUSP00000153304
Ensembl peptide - ENSMUSP00000109229
NCBI entrez gene - 224792     See in Manteia.
MGI - MGI:2182928
RefSeq - XM_006524124
RefSeq - XM_006524125
RefSeq - XM_006524129
RefSeq - XM_006524128
RefSeq - XM_006524127
RefSeq - NM_001081178
RefSeq - NM_001357332
RefSeq - XM_017317437
RefSeq - XM_006524126
RefSeq Peptide - NP_001344261
RefSeq Peptide - NP_001074647
swissprot - A0A286YE42
swissprot - A0A286YCD3
swissprot - G5E8Q8
swissprot - A0A286YD74
swissprot - A0A286YDT5
Ensembl - ENSMUSG00000056492
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000039320Gallus gallus
 ADGRF5ENSG00000069122Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Adgrf1 / Q8VEC3 / Adhesion G-protein coupled receptor F1 / Q5T601*ENSMUSG0000004129322
Adgrf3 / Q58Y75 / Adhesion G-protein coupled receptor F3 / Q8IZF5*ENSMUSG0000006764218
Adgrf4 / adhesion G protein-coupled receptor F4 / Q8IZF3*ENSMUSG0000002391817
Adgrf2 / E9Q4J9 / Adhesion G-protein coupled receptor F2 / Q8IZF7*ENSMUSG0000005789917
Adgrb2 / Q8CGM1 / Adhesion G protein-coupled receptor B2 / O60241*ENSMUSG0000002878215
Adgrb3 / Q80ZF8 / Adhesion G protein-coupled receptor B3 / O60242*ENSMUSG0000003356915
Adgrb1 / Q3UHD1 / Adhesion G protein-coupled receptor B1 Vasculostatin-120 Vasculostatin-40 / O14514* / adhesion G protein-coupled receptor B1*ENSMUSG0000003473015
Cfp / P11680 / complement factor properdin / P27918*ENSMUSG000000011285


Protein motifs (from Interpro)
Interpro ID Name
 IPR000082  SEA domain
 IPR000203  GPS motif
 IPR000832  GPCR, family 2, secretin-like
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR008078  GPCR family 2, Ig-hepta-like receptor
 IPR013098  Immunoglobulin I-set
 IPR013151  Immunoglobulin
 IPR013783  Immunoglobulin-like fold
 IPR017981  GPCR, family 2-like
 IPR017983  GPCR, family 2, secretin-like, conserved site
 IPR032471  GAIN domain, N-terminal
 IPR036179  Immunoglobulin-like domain superfamily
 IPR036364  SEA domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006112 energy reserve metabolic process IMP
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0019216 regulation of lipid metabolic process IMP
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0043031 negative regulation of macrophage activation IMP
 biological_processGO:0043129 surfactant homeostasis IMP
 biological_processGO:0045444 fat cell differentiation IMP
 biological_processGO:0071073 positive regulation of phospholipid biosynthetic process IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0045177 apical part of cell IDA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA


Pathways (from Reactome)
Pathway description
Surfactant metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H

 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H

 MP:0000194 hypercalcemia "abnormally high concentration of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H

 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
Show

Allelic Composition: Hdctm1Nagy/Hdc+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Vps54wr/Vps54wr
Genetic Background: involves: C57BL/6J * C57BL/Fa

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Vps54wr/Vps54wr
Genetic Background: involves: C57BL/6J * C57BL/Fa

Allelic Composition: Adgrf5tm1.1Bstc/Adgrf5tm1.2Bstc,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J

 MP:0001943 abnormal respiration "anomaly in the movement of gases into and out of the lung " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hdctm1Nagy/Hdc+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Vps54wr/Vps54wr
Genetic Background: involves: C57BL/6J * C57BL/Fa

Allelic Composition: Adgrf5tm1.2Jpbs/Adgrf5tm1.2Jpbs
Genetic Background: BALB/c-Adgrf5tm1.2Jpbs

 MP:0001958 emphysema "lung disease characterized by increased size of terminal bronchioles with destructive changes in their walls and reduction in number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33629]
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Allelic Composition: Nacc1tm1.1Jlwa/Nacc1+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vps54wr/Vps54wr
Genetic Background: involves: C57BL/6J * C57BL/Fa

 MP:0002133 abnormal respiratory system physiology "anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hdctm1Nagy/Hdc+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nacc1tm1.1Jlwa/Nacc1+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Adgrf5tm1.2Jpbs/Adgrf5tm1.2Jpbs
Genetic Background: BALB/c-Adgrf5tm1.2Jpbs

 MP:0002275 abnormal type II pneumocyte morphology "any structural anomaly of the epithelial cells lining the alveoli that produce surfactant " [Pathology , 2nd edition:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Vps54wr/Vps54wr
Genetic Background: involves: C57BL/6J * C57BL/Fa

 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H

 MP:0003982 increased cholesterol level "greater than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Vps54wr/Vps54wr
Genetic Background: involves: C57BL/6J * C57BL/Fa

Allelic Composition: Adgrf5tm1.1Bstc/Adgrf5tm1.2Bstc,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J

 MP:0004778 increased foam cell number "greater than normal number of a type of macrophage containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions" [CL:0000517]
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Allelic Composition: Vps54wr/Vps54wr
Genetic Background: involves: C57BL/6J * C57BL/Fa

 MP:0004781 abnormal surfactant composition "anomaly in the chemical consituents of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adgrf5tm1.2Jpbs/Adgrf5tm1.2Jpbs
Genetic Background: BALB/c-Adgrf5tm1.2Jpbs

 MP:0004782 abnormal surfactant physiology "anomaly in the production, composition or function of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Vps54wr/Vps54wr
Genetic Background: involves: C57BL/6J * C57BL/Fa

Allelic Composition: Adgrf5tm1.2Jpbs/Adgrf5tm1.2Jpbs
Genetic Background: BALB/c-Adgrf5tm1.2Jpbs

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H

 MP:0005344 increased circulating bilirubin level "greater than the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
Show

Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
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Allelic Composition: Nacc1tm1.1Jlwa/Nacc1+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005426 tachypnea "rapid breathing" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Adgrf5tm1.2Jpbs/Adgrf5tm1.2Jpbs
Genetic Background: BALB/c-Adgrf5tm1.2Jpbs

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Ctsktm1(cre)Ska/Ctsk+,Snx10tm1c(EUCOMM)Raba/Snx10tm1c(EUCOMM)Raba
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0005562 decreased mean corpuscular hemoglobin "less than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H

 MP:0005630 increased lung weight "greater than the normal state of the physical heaviness of the lung" [RGD:Rat Genome Database submission]
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Allelic Composition: Nacc1tm1.1Jlwa/Nacc1+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008245 abnormal alveolar macrophage morphology "any structural anomaly of the round, granular, mononuclear phagocytes found in the alveoli of the lungs which ingest small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells" [CL:0000583, MESH:A.11.329.372.600]
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Allelic Composition: Nacc1tm1.1Jlwa/Nacc1+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Adgrf5tm1.2Jpbs/Adgrf5tm1.2Jpbs
Genetic Background: BALB/c-Adgrf5tm1.2Jpbs

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H

 MP:0010052 increased grip strength "greater ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H

 MP:0010067 increased red blood cell distribution width "higher than normal coefficient of variance (reference range) of the red blood cell volume for an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", NCI:C64800 "NCI Thesaurus (Code C64800)"]
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Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H

 MP:0010810 increased type II pneumocyte number "greater number of the granular and roughly cuboidal cells typically found at the alveolar-septal junction that modulate the fluid surrounding the alveolar epithelium by secreting and recycling surfactants, and also contribute to tissue repair and can differentiate after injury into a type I pneumocyte; type II cells cover a much smaller surface area than type I cells (less than 5 percent), but are much more numerous and contain lamellar bodies on the apical surface where surfactant is stored" [ISBN:0412046911, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", PMID:8540632]
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Allelic Composition: Nacc1tm1.1Jlwa/Nacc1+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0010891 increased alveolar lamellar body number "greater number of the specialized secretory organelles found in the cytoplasm of type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Vps54wr/Vps54wr
Genetic Background: involves: C57BL/6J * C57BL/Fa

 MP:0010992 increased surfactant secretion "greater production or release from pneumocytes of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Vps54wr/Vps54wr
Genetic Background: involves: C57BL/6J * C57BL/Fa

Allelic Composition: Adgrf5tm1.1Bstc/Adgrf5tm1.2Bstc,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J

Allelic Composition: Adgrf5tm1Shiro/Adgrf5tm1Shiro
Genetic Background: B6.Cg-Adgrf5tm1Shiro

Allelic Composition: Adgrf5tm1.2Jpbs/Adgrf5tm1.2Jpbs
Genetic Background: BALB/c-Adgrf5tm1.2Jpbs

 MP:0010998 pulmonary alveolar proteinosis "abnormal intra-alveolar accumulation of an amorphous, largely cell-free, surfactant-like lipoproteinaceous material that is not easily cleared from the lungs" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Vps54wr/Vps54wr
Genetic Background: involves: C57BL/6J * C57BL/Fa

Allelic Composition: Adgrf5tm1.1Bstc/Adgrf5tm1.2Bstc,Tg(Sftpc-cre)1Blh/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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