MP:0000063 | reduced bone density | "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315] |
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Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H
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MP:0000186 | decreased circulating HDL cholesterol level | "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H
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MP:0000194 | hypercalcemia | "abnormally high concentration of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H
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MP:0000208 | decreased hematocrit | "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H
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MP:0000221 | decreased WBC count | "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H
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MP:0001175 | abnormal lung morphology | "malformed organ of respiration" [J:35802] |
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Allelic Composition: Hdctm1Nagy/Hdc+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0001258 | decreased body length | "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator] |
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Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H
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MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
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Allelic Composition: Vps54wr/Vps54wr Genetic Background: involves: C57BL/6J * C57BL/Fa
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MP:0001325 | abnormal retina morphology | "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H
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MP:0001547 | abnormal lipid level | "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Vps54wr/Vps54wr Genetic Background: involves: C57BL/6J * C57BL/Fa
Allelic Composition: Adgrf5tm1.1Bstc/Adgrf5tm1.2Bstc,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J
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MP:0001943 | abnormal respiration | "anomaly in the movement of gases into and out of the lung " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Hdctm1Nagy/Hdc+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0001954 | respiratory distress | "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931] |
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Allelic Composition: Vps54wr/Vps54wr Genetic Background: involves: C57BL/6J * C57BL/Fa
Allelic Composition: Adgrf5tm1.2Jpbs/Adgrf5tm1.2Jpbs Genetic Background: BALB/c-Adgrf5tm1.2Jpbs
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MP:0001958 | emphysema | "lung disease characterized by increased size of terminal bronchioles with destructive changes in their walls and reduction in number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33629] |
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Allelic Composition: Nacc1tm1.1Jlwa/Nacc1+ Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Vps54wr/Vps54wr Genetic Background: involves: C57BL/6J * C57BL/Fa
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MP:0002133 | abnormal respiratory system physiology | "anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Hdctm1Nagy/Hdc+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0002270 | abnormal alveoli morphology | "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Nacc1tm1.1Jlwa/Nacc1+ Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Adgrf5tm1.2Jpbs/Adgrf5tm1.2Jpbs Genetic Background: BALB/c-Adgrf5tm1.2Jpbs
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MP:0002275 | abnormal type II pneumocyte morphology | "any structural anomaly of the epithelial cells lining the alveoli that produce surfactant " [Pathology , 2nd edition:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Vps54wr/Vps54wr Genetic Background: involves: C57BL/6J * C57BL/Fa
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MP:0002591 | decreased mean corpuscular volume | "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H
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MP:0002764 | short tibia | " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H
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MP:0002874 | decreased hemoglobin content | "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H
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MP:0003982 | increased cholesterol level | "greater than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Vps54wr/Vps54wr Genetic Background: involves: C57BL/6J * C57BL/Fa
Allelic Composition: Adgrf5tm1.1Bstc/Adgrf5tm1.2Bstc,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J
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MP:0004778 | increased foam cell number | "greater than normal number of a type of macrophage containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions" [CL:0000517] |
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Allelic Composition: Vps54wr/Vps54wr Genetic Background: involves: C57BL/6J * C57BL/Fa
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MP:0004781 | abnormal surfactant composition | "anomaly in the chemical consituents of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Adgrf5tm1.2Jpbs/Adgrf5tm1.2Jpbs Genetic Background: BALB/c-Adgrf5tm1.2Jpbs
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MP:0004782 | abnormal surfactant physiology | "anomaly in the production, composition or function of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Vps54wr/Vps54wr Genetic Background: involves: C57BL/6J * C57BL/Fa
Allelic Composition: Adgrf5tm1.2Jpbs/Adgrf5tm1.2Jpbs Genetic Background: BALB/c-Adgrf5tm1.2Jpbs
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MP:0005179 | decreased total circulating cholesterol level | "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H
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MP:0005293 | impaired glucose tolerance | "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H
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MP:0005344 | increased circulating bilirubin level | "greater than the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204] |
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Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H
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MP:0005425 | increased macrophage count | "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418] |
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Allelic Composition: Nacc1tm1.1Jlwa/Nacc1+ Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0005426 | tachypnea | "rapid breathing" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Adgrf5tm1.2Jpbs/Adgrf5tm1.2Jpbs Genetic Background: BALB/c-Adgrf5tm1.2Jpbs
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MP:0005559 | increased circulating glucose level | "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission] |
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Allelic Composition: Ctsktm1(cre)Ska/Ctsk+,Snx10tm1c(EUCOMM)Raba/Snx10tm1c(EUCOMM)Raba Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj
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MP:0005562 | decreased mean corpuscular hemoglobin | "less than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H
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MP:0005565 | increased blood urea nitrogen level | "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H
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MP:0005630 | increased lung weight | "greater than the normal state of the physical heaviness of the lung" [RGD:Rat Genome Database submission] |
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Allelic Composition: Nacc1tm1.1Jlwa/Nacc1+ Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0008245 | abnormal alveolar macrophage morphology | "any structural anomaly of the round, granular, mononuclear phagocytes found in the alveoli of the lungs which ingest small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells" [CL:0000583, MESH:A.11.329.372.600] |
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Allelic Composition: Nacc1tm1.1Jlwa/Nacc1+ Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Adgrf5tm1.2Jpbs/Adgrf5tm1.2Jpbs Genetic Background: BALB/c-Adgrf5tm1.2Jpbs
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MP:0010025 | decreased total body fat amount | "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H
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MP:0010052 | increased grip strength | "greater ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"] |
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Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H
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MP:0010067 | increased red blood cell distribution width | "higher than normal coefficient of variance (reference range) of the red blood cell volume for an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", NCI:C64800 "NCI Thesaurus (Code C64800)"] |
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Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H
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MP:0010124 | decreased bone mineral content | "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H
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MP:0010810 | increased type II pneumocyte number | "greater number of the granular and roughly cuboidal cells typically found at the alveolar-septal junction that modulate the fluid surrounding the alveolar epithelium by secreting and recycling surfactants, and also contribute to tissue repair and can differentiate after injury into a type I pneumocyte; type II cells cover a much smaller surface area than type I cells (less than 5 percent), but are much more numerous and contain lamellar bodies on the apical surface where surfactant is stored" [ISBN:0412046911, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", PMID:8540632] |
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Allelic Composition: Nacc1tm1.1Jlwa/Nacc1+ Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0010891 | increased alveolar lamellar body number | "greater number of the specialized secretory organelles found in the cytoplasm of type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Vps54wr/Vps54wr Genetic Background: involves: C57BL/6J * C57BL/Fa
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MP:0010992 | increased surfactant secretion | "greater production or release from pneumocytes of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Vps54wr/Vps54wr Genetic Background: involves: C57BL/6J * C57BL/Fa
Allelic Composition: Adgrf5tm1.1Bstc/Adgrf5tm1.2Bstc,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J
Allelic Composition: Adgrf5tm1Shiro/Adgrf5tm1Shiro Genetic Background: B6.Cg-Adgrf5tm1Shiro
Allelic Composition: Adgrf5tm1.2Jpbs/Adgrf5tm1.2Jpbs Genetic Background: BALB/c-Adgrf5tm1.2Jpbs
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MP:0010998 | pulmonary alveolar proteinosis | "abnormal intra-alveolar accumulation of an amorphous, largely cell-free, surfactant-like lipoproteinaceous material that is not easily cleared from the lungs" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Vps54wr/Vps54wr Genetic Background: involves: C57BL/6J * C57BL/Fa
Allelic Composition: Adgrf5tm1.1Bstc/Adgrf5tm1.2Bstc,Tg(Sftpc-cre)1Blh/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * DBA/2
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