ENSMUSG00000034271


Mus musculus

Features
Gene ID: ENSMUSG00000034271
  
Biological name :Jdp2
  
Synonyms : Jdp2 / Jun dimerization protein 2 / P97875
  
Possible biological names infered from orthology : Q8WYK2
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: D2
Gene start: 85599027
Gene end: 85639878
  
Corresponding Affymetrix probe sets: 10397351 (MoGene1.0st)   1424972_at (Mouse Genome 430 2.0 Array)   1450350_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000059724
Ensembl peptide - ENSMUSP00000129985
Ensembl peptide - ENSMUSP00000136823
Ensembl peptide - ENSMUSP00000152652
NCBI entrez gene - 81703     See in Manteia.
MGI - MGI:1932093
RefSeq - XM_011244219
RefSeq - NM_001205052
RefSeq - NM_001205053
RefSeq - NM_030887
RefSeq - XM_011244218
RefSeq Peptide - NP_001191982
RefSeq Peptide - NP_112149
RefSeq Peptide - NP_001191981
swissprot - P97875
swissprot - A0A1Y7VLU6
Ensembl - ENSMUSG00000034271
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 jdp2aENSDARG00000040137Danio rerio
 JDP2ENSGALG00000010322Gallus gallus
 JDP2ENSG00000140044Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Atf3 / Q60765 / Cyclic AMP-dependent transcription factor ATF-3 / P18847* / activating transcription factor 3*ENSMUSG0000002662850


Protein motifs (from Interpro)
Interpro ID Name
 IPR000837  AP-1 transcription factor
 IPR004827  Basic-leucine zipper domain
 IPR008917  Transcription factor, Skn-1-like, DNA-binding domain superfamily
 IPR029819  Jun dimerization protein 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0031063 regulation of histone deacetylation IEA
 biological_processGO:0031065 positive regulation of histone deacetylation IGI
 biological_processGO:0045599 negative regulation of fat cell differentiation IDA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: B4gat1m1Ddg/B4gat1tm1(KOMP)Vlcg
Genetic Background: involves: C3H/He * C57BL/6 * C57BL/6NTac

 MP:0000067 osteopetrosis "excessive formation of dense trabecular bone and excessive calcified cartilage formation; may lead to anemia and extramedullary hematopoiesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: B4gat1m1Ddg/B4gat1tm1(KOMP)Vlcg
Genetic Background: involves: C3H/He * C57BL/6 * C57BL/6NTac

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: B4gat1m1Ddg/B4gat1tm1(KOMP)Vlcg
Genetic Background: involves: C3H/He * C57BL/6 * C57BL/6NTac

 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hcn1tm2Kndl/Hcn1tm2Kndl,Olfr160tm6Mom/Olfr160tm6Mom
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

 MP:0000592 short tail "reduced length of tail compared to control " [J:55583]
Show

Allelic Composition: Hcn1tm2Kndl/Hcn1tm2Kndl,Olfr160tm6Mom/Olfr160tm6Mom
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

Allelic Composition: Jdp2tm1Kkyo/Jdp2tm1Kkyo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001200 thick skin "greater depth of skin " [J:47225]
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Allelic Composition: Jdp2tm1Kkyo/Jdp2tm1Kkyo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdx2tm1.2Aral/Cdx2tm1Fbe
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: B4gat1m1Ddg/B4gat1tm1(KOMP)Vlcg
Genetic Background: involves: C3H/He * C57BL/6 * C57BL/6NTac

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: B4gat1m1Ddg/B4gat1tm1(KOMP)Vlcg
Genetic Background: involves: C3H/He * C57BL/6 * C57BL/6NTac

 MP:0002724 enhanced wound healing "increased ability to self-repair and close wounds" [dlb:Donna Burkart , Mouse Genome Informatics Curator, J:42016]
Show

Allelic Composition: Jdp2tm1Kkyo/Jdp2tm1Kkyo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Jdp2tm1Kkyo/Jdp2tm1Kkyo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: B4gat1m1Ddg/B4gat1tm1(KOMP)Vlcg
Genetic Background: involves: C3H/He * C57BL/6 * C57BL/6NTac

 MP:0003795 abnormal bone structure 
Show

Allelic Composition: B4gat1m1Ddg/B4gat1tm1(KOMP)Vlcg
Genetic Background: involves: C3H/He * C57BL/6 * C57BL/6NTac

 MP:0004982 abnormal osteoclast morphology "any structural anomaly of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: B4gat1m1Ddg/B4gat1tm1(KOMP)Vlcg
Genetic Background: involves: C3H/He * C57BL/6 * C57BL/6NTac

 MP:0005076 abnormal cell differentiation "anomaly in the process whereby relatively unspecialized cells, e. g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism s life history" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sp1tm1Phi/Sp1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005399 increased susceptibility to fungal infection "greater likelihood that an organism will develop ill effects from infection by a yeast or mold, or from components of, or toxins produced by, these organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: B4gat1m1Ddg/B4gat1tm1(KOMP)Vlcg
Genetic Background: involves: C3H/He * C57BL/6 * C57BL/6NTac

 MP:0005501 abnormal skin physiology "atypical function of the membranous protective covering of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Jdp2tm1Kkyo/Jdp2tm1Kkyo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: B4gat1m1Ddg/B4gat1tm1(KOMP)Vlcg
Genetic Background: involves: C3H/He * C57BL/6 * C57BL/6NTac

 MP:0009115 abnormal fat cell morphology "any structural anomaly of a fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]
Show

Allelic Composition: Sp1tm1Phi/Sp1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010868 increased bone trabecula number "increased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: B4gat1m1Ddg/B4gat1tm1(KOMP)Vlcg
Genetic Background: involves: C3H/He * C57BL/6 * C57BL/6NTac

 MP:0010878 increased trabecular bone volume "increase in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: B4gat1m1Ddg/B4gat1tm1(KOMP)Vlcg
Genetic Background: involves: C3H/He * C57BL/6 * C57BL/6NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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