ENSMUSG00000034460


Mus musculus

Features
Gene ID: ENSMUSG00000034460
  
Biological name :Six4
  
Synonyms : Homeobox protein SIX4 / Q61321 / Six4
  
Possible biological names infered from orthology : Q9UIU6 / SIX homeobox 4
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: C3
Gene start: 73099609
Gene end: 73113456
  
Corresponding Affymetrix probe sets: 10400971 (MoGene1.0st)   1425767_a_at (Mouse Genome 430 2.0 Array)   1427701_a_at (Mouse Genome 430 2.0 Array)   1439753_x_at (Mouse Genome 430 2.0 Array)   1456862_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000036150
Ensembl peptide - ENSMUSP00000135699
NCBI entrez gene - 20474     See in Manteia.
MGI - MGI:106034
RefSeq - NM_011382
RefSeq - XM_006515632
RefSeq Peptide - NP_035512
swissprot - H3BL91
swissprot - Q61321
Ensembl - ENSMUSG00000034460
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 six4aENSDARG00000004695Danio rerio
 six4bENSDARG00000031983Danio rerio
 SIX4ENSGALG00000017389Gallus gallus
 SIX4ENSG00000100625Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Six5 / P70178 / Homeobox protein SIX5 / Q8N196* / SIX homeobox 5*ENSMUSG0000004084130
Six2 / Q62232 / Homeobox protein SIX2 / Q9NPC8* / SIX homeobox 2*ENSMUSG0000002413419
Six1 / Q62231 / Homeobox protein SIX1 / Q15475* / SIX homeobox 1*ENSMUSG0000005136719
Six6 / Q9QZ28 / sine oculis-related homeobox 6 / O95475* / SIX homeobox 6*ENSMUSG0000002109915
Six3 / Q62233 / Homeobox protein SIX3 / O95343* / SIX homeobox 3*ENSMUSG0000003880515


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR031701  Homeobox protein SIX1, N-terminal SD domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007519 skeletal muscle tissue development IMP
 biological_processGO:0008582 regulation of synaptic growth at neuromuscular junction IGI
 biological_processGO:0008584 male gonad development IMP
 biological_processGO:0010468 regulation of gene expression IGI
 biological_processGO:0030238 male sex determination IMP
 biological_processGO:0030910 olfactory placode formation IMP
 biological_processGO:0032880 regulation of protein localization IGI
 biological_processGO:0034504 protein localization to nucleus IDA
 biological_processGO:0042472 inner ear morphogenesis IGI
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043524 negative regulation of neuron apoptotic process IMP
 biological_processGO:0043586 tongue development IMP
 biological_processGO:0045214 sarcomere organization IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0046661 male sex differentiation IMP
 biological_processGO:0048538 thymus development IGI
 biological_processGO:0048699 generation of neurons IMP
 biological_processGO:0048701 embryonic cranial skeleton morphogenesis IGI
 biological_processGO:0048704 embryonic skeletal system morphogenesis IGI
 biological_processGO:0048856 anatomical structure development IGI
 biological_processGO:0050678 regulation of epithelial cell proliferation IMP
 biological_processGO:0051451 myoblast migration IGI
 biological_processGO:0060037 pharyngeal system development IMP
 biological_processGO:0061055 myotome development IMP
 biological_processGO:0061197 fungiform papilla morphogenesis IMP
 biological_processGO:0061551 trigeminal ganglion development IMP
 biological_processGO:0072075 metanephric mesenchyme development IMP
 biological_processGO:0072095 regulation of branch elongation involved in ureteric bud branching IMP
 biological_processGO:0072107 positive regulation of ureteric bud formation IMP
 biological_processGO:0090190 positive regulation of branching involved in ureteric bud morphogenesis IMP
 biological_processGO:0098528 skeletal muscle fiber differentiation IMP
 biological_processGO:1902725 negative regulation of satellite cell differentiation IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000026 abnormal inner ear morphology "malformation or malfunction of any components of the labyrinth, including the semicircular canals, vestibule and cochlea" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]
Show

Allelic Composition: Fras1bl/Fras1bl,Frem2my-Ucl/Frem2my-Ucl
Genetic Background: involves: 101/H * C3H/HeH * NMRI

 MP:0000088 short mandible "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fras1bl/Fras1bl,Frem2my-Ucl/Frem2my-Ucl
Genetic Background: involves: 101/H * C3H/HeH * NMRI

 MP:0000090 absent premaxilla "missing anterior and interior portion of the maxilla" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489]
Show

Allelic Composition: Fras1bl/Fras1bl,Frem2my-Ucl/Frem2my-Ucl
Genetic Background: involves: 101/H * C3H/HeH * NMRI

 MP:0000097 short maxilla "reduced length of the upper jaw bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Fras1bl/Fras1bl,Frem2my-Ucl/Frem2my-Ucl
Genetic Background: involves: 101/H * C3H/HeH * NMRI

 MP:0000430 absent maxillary shelf "missing outgrowth of the maxilla; normally fuses with palatine shelf to form secondary palate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]
Show

Allelic Composition: Fras1bl/Fras1bl,Frem2my-Ucl/Frem2my-Ucl
Genetic Background: involves: 101/H * C3H/HeH * NMRI

 MP:0000550 abnormal forelimb morphology "malformation of the entire anterior extremities" [MGI:tc]
Show

Allelic Composition: Fras1bl/Fras1bl,Frem2my-Ucl/Frem2my-Ucl
Genetic Background: involves: 101/H * C3H/HeH * NMRI

 MP:0000556 abnormal hindlimb morphology "malformation of the entire posterior extremities" [MGI:tc]
Show

Allelic Composition: Fras1bl/Fras1bl,Frem2my-Ucl/Frem2my-Ucl
Genetic Background: involves: 101/H * C3H/HeH * NMRI

 MP:0000733 abnormal muscle development "anomalous differentiation of muscle tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fras1bl/Fras1bl,Frem2my-Ucl/Frem2my-Ucl
Genetic Background: involves: 101/H * C3H/HeH * NMRI

 MP:0000734 muscle hypoplasia "underdevelopment or atrophy of muscle" [J:15108]
Show

Allelic Composition: Six1tm1Mair/Six1tm1Mair,Six4tm1Mair/Six4tm1Mair
Genetic Background: either: 129/Sv-Six1tm1Mair Six4tm1Mair or B6N.129-Six1tm1Mair Six4tm1Mair

 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Six1tm1Mair/Six1tm1Mair,Six4tm1Mair/Six4tm1Mair
Genetic Background: either: 129/Sv-Six1tm1Mair Six4tm1Mair or B6N.129-Six1tm1Mair Six4tm1Mair

 MP:0000961 abnormal dorsal root ganglia morphology "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]
Show

Allelic Composition: Six1tm1Kwk/Six1tm1Kwk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001270 distended abdomen "abdomen appears curved outward or swollen; can be due to skeletal axial defects, enlarged visceral organs or megacolon" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fras1bl/Fras1bl,Frem2my-Ucl/Frem2my-Ucl
Genetic Background: involves: 101/H * C3H/HeH * NMRI

 MP:0001302 eyelids open at birth "widely open eyes instead of closed at perinatal stage" [J:51966]
Show

Allelic Composition: Six1tm1Mair/Six1tm1Mair,Six4tm1Mair/Six4tm1Mair
Genetic Background: either: 129/Sv-Six1tm1Mair Six4tm1Mair or B6N.129-Six1tm1Mair Six4tm1Mair

 MP:0001512 trunk curl "posture of the trunk in a curled position" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fras1bl/Fras1bl,Frem2my-Ucl/Frem2my-Ucl
Genetic Background: involves: 101/H * C3H/HeH * NMRI

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Six1tm1Mair/Six1tm1Mair,Six4tm1Mair/Six4tm1Mair
Genetic Background: either: 129/Sv-Six1tm1Mair Six4tm1Mair or B6N.129-Six1tm1Mair Six4tm1Mair

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mtrtm1Lcb/Mtrtm1Lcb
Genetic Background: involves: 129S/SvEv * Black Swiss

 MP:0002750 exophthalmos "protrusion of one or both eyeballs" [J:47965, il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Six1tm1Mair/Six1tm1Mair,Six4tm1Mair/Six4tm1Mair
Genetic Background: either: 129/Sv-Six1tm1Mair Six4tm1Mair or B6N.129-Six1tm1Mair Six4tm1Mair

 MP:0003090 abnormal muscle progenitor cell migration "defects in the movement of cells that will develop into muscle cells out of the somites and/or to the appropriate location in the body" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Six1tm1Mair/Six1tm1Mair,Six4tm1Mair/Six4tm1Mair
Genetic Background: either: 129/Sv-Six1tm1Mair Six4tm1Mair or B6N.129-Six1tm1Mair Six4tm1Mair

 MP:0003138 absent tympanic ring "missing the bony ring at the ear canal to which the tympanic membrane is attached" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:46972]
Show

Allelic Composition: Six1tm1Mair/Six1tm1Mair,Six4tm1Mair/Six4tm1Mair
Genetic Background: either: 129/Sv-Six1tm1Mair Six4tm1Mair or B6N.129-Six1tm1Mair Six4tm1Mair

 MP:0003142 anotia "congenital absence of one or both auricles of the ears" [J:57313, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Six1tm1Mair/Six1tm1Mair,Six4tm1Mair/Six4tm1Mair
Genetic Background: either: 129/Sv-Six1tm1Mair Six4tm1Mair or B6N.129-Six1tm1Mair Six4tm1Mair

 MP:0004422 small temporal bone "reduced size of the large, irregular bone located at the base and side of the skull" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Six1tm1Mair/Six1tm1Mair,Six4tm1Mair/Six4tm1Mair
Genetic Background: either: 129/Sv-Six1tm1Mair Six4tm1Mair or B6N.129-Six1tm1Mair Six4tm1Mair

 MP:0004439 absent Meckel s cartilage "absence of this cartilage bar in the mandibular arch that forms a temporary supporting structure in the embryonic mandible; gives rise to middle ear bones and sphenomandibular and anterior malleolar ligaments" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Six1tm1Mair/Six1tm1Mair,Six4tm1Mair/Six4tm1Mair
Genetic Background: either: 129/Sv-Six1tm1Mair Six4tm1Mair or B6N.129-Six1tm1Mair Six4tm1Mair

 MP:0004467 absent zygomatic bone "absence of the quadrilateral bone that forms the prominence of the cheek" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Six1tm1Mair/Six1tm1Mair,Six4tm1Mair/Six4tm1Mair
Genetic Background: either: 129/Sv-Six1tm1Mair Six4tm1Mair or B6N.129-Six1tm1Mair Six4tm1Mair

 MP:0004473 absent nasal bone "absence of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Six1tm1Mair/Six1tm1Mair,Six4tm1Mair/Six4tm1Mair
Genetic Background: either: 129/Sv-Six1tm1Mair Six4tm1Mair or B6N.129-Six1tm1Mair Six4tm1Mair

 MP:0004672 short ribs "reduced length of the bones forming the bony wall of the chest" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Six1tm1Mair/Six1tm1Mair,Six4tm1Mair/Six4tm1Mair
Genetic Background: either: 129/Sv-Six1tm1Mair Six4tm1Mair or B6N.129-Six1tm1Mair Six4tm1Mair

 MP:0006211 small orbits "reduced size of the orbits" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Six1tm1Mair/Six1tm1Mair,Six4tm1Mair/Six4tm1Mair
Genetic Background: either: 129/Sv-Six1tm1Mair Six4tm1Mair or B6N.129-Six1tm1Mair Six4tm1Mair

 MP:0006284 absent hypaxial muscle "absence of the muscles derived from the lateral myotome and lateral portion of the dermomyotome; these include the thoracic intercostal and abdominal muscles, limb muscles and superficial back muscles, as well as the diaphragm and the tip of the tongue" [J:86619, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Six1tm1Mair/Six1tm1Mair,Six4tm1Mair/Six4tm1Mair
Genetic Background: either: 129/Sv-Six1tm1Mair Six4tm1Mair or B6N.129-Six1tm1Mair Six4tm1Mair

 MP:0008148 abnormal rib-sternum attachment "any anomaly in the in the normal joining of the ribs to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Six1tm1Mair/Six1tm1Mair,Six4tm1Mair/Six4tm1Mair
Genetic Background: either: 129/Sv-Six1tm1Mair Six4tm1Mair or B6N.129-Six1tm1Mair Six4tm1Mair

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Six1tm1Kwk/Six1tm1Kwk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Six1tm1Mair/Six1tm1Mair,Six4tm1Mair/Six4tm1Mair
Genetic Background: either: 129/Sv-Six1tm1Mair Six4tm1Mair or B6N.129-Six1tm1Mair Six4tm1Mair

 MP:0013929 absent eye muscles 
Show

Allelic Composition: Six1tm1Mair/Six1tm1Mair,Six4tm1Mair/Six4tm1Mair
Genetic Background: either: 129/Sv-Six1tm1Mair Six4tm1Mair or B6N.129-Six1tm1Mair Six4tm1Mair

 MP:0013964 absent tongue muscles 
Show

Allelic Composition: Six1tm1Mair/Six1tm1Mair,Six4tm1Mair/Six4tm1Mair
Genetic Background: either: 129/Sv-Six1tm1Mair Six4tm1Mair or B6N.129-Six1tm1Mair Six4tm1Mair

 MP:0030208 abnormal intrinsic tongue muscle morphology "any structural anomaly of any of the four paired muscles that originate and insert within the tongue, running along its length; these muscles alter the shape of the tongue by lengthening and shortening it, curling and uncurling its apex and edges, and flattening and rounding its surface; they include the superior longitudinal muscle, the inferior longitudinal muscle, the vertical muscle, and the transverse muscle" [https://en.wikipedia.org/wiki/Tongue, https://www.imaios.com/en/e-Anatomy/Anatomical-Parts/Muscles-of-tongue, MGI:anna]
Show

Allelic Composition: Six1tm1Mair/Six1tm1Mair,Six4tm1Mair/Six4tm1Mair
Genetic Background: either: 129/Sv-Six1tm1Mair Six4tm1Mair or B6N.129-Six1tm1Mair Six4tm1Mair

 MP:0030210 abnormal genioglossus muscle morphology "any structural anomaly of the paired, fan-shaped extrinsic tongue muscle which forms the majority of the body of the tongue, arises from the mental spine of the mandible and inserts into the hyoid bone and the bottom of the tongue; its action protracts and depresses the tongue" [https://en.wikipedia.org/wiki/Genioglossus, MGI:anna]
Show

Allelic Composition: Six1tm1Mair/Six1tm1Mair,Six4tm1Mair/Six4tm1Mair
Genetic Background: either: 129/Sv-Six1tm1Mair Six4tm1Mair or B6N.129-Six1tm1Mair Six4tm1Mair

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr