ENSMUSG00000034912


Mus musculus

Features
Gene ID: ENSMUSG00000034912
  
Biological name :Mdga2
  
Synonyms : MAM domain-containing glycosylphosphatidylinositol anchor protein 2 / Mdga2 / P60755
  
Possible biological names infered from orthology : MAM domain containing glycosylphosphatidylinositol anchor 2 / Q7Z553
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: C2
Gene start: 66466060
Gene end: 67222549
  
Corresponding Affymetrix probe sets: 10400607 (MoGene1.0st)   10400609 (MoGene1.0st)   1436139_at (Mouse Genome 430 2.0 Array)   1442206_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000137608
Ensembl peptide - ENSMUSP00000152613
Ensembl peptide - ENSMUSP00000152548
Ensembl peptide - ENSMUSP00000152112
Ensembl peptide - ENSMUSP00000152049
Ensembl peptide - ENSMUSP00000046761
Ensembl peptide - ENSMUSP00000098930
Ensembl peptide - ENSMUSP00000109575
NCBI entrez gene - 320772     See in Manteia.
MGI - MGI:2444706
RefSeq - XM_006516013
RefSeq - NM_001193266
RefSeq - NM_207010
RefSeq Peptide - NP_001180195
RefSeq Peptide - NP_996893
swissprot - Q3UV20
swissprot - B2RQF5
swissprot - P60755
swissprot - Q3UUB8
swissprot - A0A1Y7VJM7
swissprot - F6UYI7
swissprot - A0A1Y7VIL8
swissprot - A0A217FL82
Ensembl - ENSMUSG00000034912
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mdga2aENSDARG00000024017Danio rerio
 MDGA2ENSGALG00000012228Gallus gallus
 MDGA2ENSG00000139915Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mdga1 / MAM domain containing glycosylphosphatidylinositol anchor 1 / Q8NFP4*ENSMUSG0000004355752
A2AJX4 / Malrd1 / MAM and LDL-receptor class A domain-containing protein 1 / Q5VYJ5* / MAM and LDL receptor class A domain containing 1*ENSMUSG0000007552016
A2AJA7 / Mamdc4 / MAM domain containing 4 / Q6UXC1*ENSMUSG0000002694115
Mamdc2 / MAM domain containing 2 / Q7Z304*ENSMUSG0000003320713


Protein motifs (from Interpro)
Interpro ID Name
 IPR000998  MAM domain
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR003961  Fibronectin type III
 IPR007110  Immunoglobulin-like domain
 IPR013098  Immunoglobulin I-set
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR036116  Fibronectin type III superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007389 pattern specification process IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031225 anchored component of membrane IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Post-translational modification: synthesis of GPI-anchored proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
Show

Allelic Composition: Prkg1tm1.1Arte/Prkg1tm1.1Arte
Genetic Background: C57BL/6-Prkg1tm1.1Arte

 MP:0000554 abnormal carpal bone morphology "malformation of the nine nodular bones of the joint between the forelimb bones and the front paws consisting of the scapholunar, triangular, greater multiangular, lesser multiangular, capitate, hamate, centrale and the sesamoids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935]
Show

Allelic Composition: Prkg1tm1.1Arte/Prkg1tm1.1Arte
Genetic Background: C57BL/6-Prkg1tm1.1Arte

 MP:0000566 synostosis "osseous union of two bones that are not normally connected" [J:13049]
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Allelic Composition: Prkg1tm1.1Arte/Prkg1tm1.1Arte
Genetic Background: C57BL/6-Prkg1tm1.1Arte

 MP:0000572 abnormal autopod morphology "malformation of the hand or foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prkg1tm1.1Arte/Prkg1tm1.1Arte
Genetic Background: C57BL/6-Prkg1tm1.1Arte

 MP:0002111 abnormal tail morphology "abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prkg1tm1.1Arte/Prkg1tm1.1Arte
Genetic Background: C57BL/6-Prkg1tm1.1Arte

 MP:0005650 abnormal limb bud morphology "aberrant structure or development of any of the swellings on the trunk of the embryo that become limbs" [hdene:Howard Dene , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:61460]
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Allelic Composition: Prkg1tm1.1Arte/Prkg1tm1.1Arte
Genetic Background: C57BL/6-Prkg1tm1.1Arte

 MP:0006280 abnormal digit development "anomaly in the formation of the digits" [J:70592, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkg1tm1.1Arte/Prkg1tm1.1Arte
Genetic Background: C57BL/6-Prkg1tm1.1Arte

 MP:0008877 abnormal DNA methylation "any anomaly in the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine of DNA" [GO:0006306]
Show

Allelic Composition: Prkg1tm1.1Arte/Prkg1tm1.1Arte
Genetic Background: C57BL/6-Prkg1tm1.1Arte

 MP:0030191 narrow snout "decreased width of the anterior facial part of the face or muzzle containing the oral and nasal regions" [MGI:anna]
Show

Allelic Composition: Prkg1tm1.1Arte/Prkg1tm1.1Arte
Genetic Background: C57BL/6-Prkg1tm1.1Arte

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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