Manteia

ENSMUSG00000075520

Mus musculus

Features

Gene ID:	ENSMUSG00000075520

Biological name :	Malrd1

Synonyms :	A2AJX4 / Malrd1 / MAM and LDL-receptor class A domain-containing protein 1

Possible biological names infered from orthology :	MAM and LDL receptor class A domain containing 1 / Q5VYJ5

Species:	Mus musculus

Chr. number:	2
Strand:	1
Band:	A2
Gene start:	15526479
Gene end:	16255555

Corresponding Affymetrix probe sets:	10469436 (MoGene1.0st) 10469453 (MoGene1.0st)

Cross references:	Ensembl peptide - ENSMUSP00000116869 NCBI entrez gene - 102635496 See in Manteia. MGI - MGI:1928271 RefSeq - NM_001310455 RefSeq Peptide - NP_001297384 swissprot - A2AJX4 Ensembl - ENSMUSG00000075520

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
A2AJA7 / Mamdc4 / MAM domain containing 4 / Q6UXC1*	ENSMUSG00000026941	15
Mamdc2 / MAM domain containing 2 / Q7Z304*	ENSMUSG00000033207	7
Mdga2 / P60755 / MAM domain-containing glycosylphosphatidylinositol anchor protein 2 / Q7Z553* / MAM domain containing glycosylphosphatidylinositol anchor 2*	ENSMUSG00000034912	7
Mdga1 / MAM domain containing glycosylphosphatidylinositol anchor 1 / Q8NFP4*	ENSMUSG00000043557	7

Protein motifs (from Interpro)

Interpro ID	Name
IPR000742	EGF-like domain
IPR000998	MAM domain
IPR002172	Low-density lipoprotein (LDL) receptor class A repeat
IPR013032	EGF-like, conserved site
IPR013320	Concanavalin A-like lectin/glucanase domain superfamily
IPR023415	Low-density lipoprotein (LDL) receptor class A, conserved site
IPR036055	LDL receptor-like superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0042632	cholesterol homeostasis	IMP
biological_process	GO:0070858	negative regulation of bile acid biosynthetic process	IMP
cellular_component	GO:0005737	cytoplasm	IDA
cellular_component	GO:0005794	Golgi apparatus	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
cellular_component	GO:0030659	cytoplasmic vesicle membrane	IEA
cellular_component	GO:0031410	cytoplasmic vesicle	IEA
molecular_function	GO:0005515	protein binding	IPI

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000183	decreased circulating LDL cholesterol level	"less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Otc^spf/Otc⁺ Genetic Background: Not Specified
MP:0002139	abnormal liver/biliary system physiology	"altered function of the liver not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Otc^spf/Otc⁺ Genetic Background: Not Specified
MP:0005085	abnormal gall bladder physiology	"anomalous action or function of the organ that stores and concentrates bile " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Raf1^tm1Bacc/Raf1^tm1Bacc Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0005146	decreased circulating VLDL cholesterol level	"less than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Otc^spf/Otc⁺ Genetic Background: Not Specified

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr