ENSMUSG00000035121
Mus musculus activity Neil2 dna binding glycosylase ap repair microtubule dna- apurinic apyrimidinic site endonuclease hydrolase zinc h catalytic lyase damaged ion class finger lyase-type ribosomal protein s -like formamidopyrimidine-dna domain dna-binding mutm-like
Features Gene ID: ENSMUSG00000035121 Biological name :Neil2 Synonyms : Endonuclease 8-like 2 / / Possible biological names infered from orthology : nei like DNA glycosylase 2 / Species: Mus musculus Chr. number: 14 Strand: -1 Band: D1 Gene start: 63182443 Gene end: 63193856 Corresponding Affymetrix probe sets: 10420736 (MoGene1.0st) Cross references: Ensembl peptide - ENSMUSP00000045200382913
See in Manteia .
MGI:2686058 XM_006519202 NM_201610 XM_006519199 NP_963904 Q1LZM6 Q1RLK4 Q6R2P8 A0A286YDY3 ENSMUSG00000035121
See expression report in BioGPS See gene description in Wikigenes See co-cited genes in PubMed Ortholog prediction (from Ensembl )Paralog prediction (from Ensembl ) Neil3 / Q8K203 / Endonuclease 8-like 3 / Q8TAT5* / nei like DNA glycosylase 3* ENSMUSG00000039396 21
Protein motifs (from Interpro ) IPR000214 Zinc finger, DNA glycosylase/AP lyase-type IPR010979 Ribosomal protein S13-like, H2TH IPR012319 Formamidopyrimidine-DNA glycosylase, catalytic domain IPR015886 DNA glycosylase/AP lyase, H2TH DNA-binding IPR035937 MutM-like, N-terminal
Gene Ontology (GO ) nitrogen compound metabolic process response to stress cellular metabolic process primary metabolic process organic substance metabolic process cellular response to stimulus nitrogen compound metabolic process response to stress cellular metabolic process primary metabolic process organic substance metabolic process cellular response to stimulus nitrogen compound metabolic process response to stress cellular metabolic process primary metabolic process organic substance metabolic process cellular response to stimulus nitrogen compound metabolic process response to stress cellular metabolic process primary metabolic process organic substance metabolic process cellular response to stimulus nitrogen compound metabolic process response to stress cellular metabolic process primary metabolic process organic substance metabolic process cellular response to stimulus nitrogen compound metabolic process response to stress cellular metabolic process primary metabolic process organic substance metabolic process cellular response to stimulus nitrogen compound metabolic process response to stress cellular metabolic process primary metabolic process organic substance metabolic process cellular response to stimulus nitrogen compound metabolic process response to stress cellular metabolic process primary metabolic process organic substance metabolic process cellular response to stimulus nitrogen compound metabolic process response to stress cellular metabolic process primary metabolic process organic substance metabolic process cellular response to stimulus nitrogen compound metabolic process response to stress cellular metabolic process primary metabolic process organic substance metabolic process cellular response to stimulus nitrogen compound metabnitrogen compound metabolic process response to stressresponse to stress cellular metabolic proccellular metabolic process primary metabolic proceprimary metabolic process organic substance metaborganic substance metabolic process cellular response to stcellular response to stimulus organic cyclic compound binding heterocyclic compound binding catalytic activity, acting on DNA protein binding ion binding hydrolase activity lyase activity organic cyclic compound binding heterocyclic compound binding catalytic activity, acting on DNA protein binding ion binding hydrolase activity lyase activity organic cyclic compound binding heterocyclic compound binding catalytic activity, acting on DNA protein binding ion binding hydrolase activity lyase activity organic cyclic compound binding heterocyclic compound binding catalytic activity, acting on DNA protein binding ion binding hydrolase activity lyase activity organic cyclic compound binding heterocyclic compound binding catalytic activity, acting on DNA protein binding ion binding hydrolase activity lyase activity organic cyclic compound binding heterocyclic compound binding catalytic activity, acting on DNA protein binding ion binding hydrolase activity lyase activity organic cyclic compound binding heterocyclic compound binding catalytic activity, acting on DNA protein binding ion binding hydrolase activity lyase activity organic cyclic compound binding heterocyclic compound binding catalytic activity, acting on DNA protein binding ion binding hydrolase activity lyase activity organic cyclic compound binding heterocyclic compound binding catalytic activity, acting on DNA protein binding ion binding hydrolase activity lyase activity organic cyclic compound binding heterocyclic compound binding catalytic activity, acting on DNA protein binding ion binding hydrolase activity lyase activity organic cyclic compoorganic cyclic compound binding heterocyclic compounheterocyclic compound binding catalytic activity, catalytic activity, acting on DNA protein bindingprotein binding ion bindingion binding hydrolase activityhydrolase activity lyase activitylyase activity cell organelle membrane-enclosed lumen supramolecular complex cell organelle membrane-enclosed lumen supramolecular complex cell organelle membrane-enclosed lumen supramolecular complex cell organelle membrane-enclosed lumen supramolecular complex cell organelle membrane-enclosed lumen supramolecular complex cell organelle membrane-enclosed lumen supramolecular complex cell organelle membrane-enclosed lumen supramolecular complex cell organelle membrane-enclosed lumen supramolecular complex cell organelle membrane-enclosed lumen supramolecular complex cell organelle membrane-enclosed lumen supramolecular complex cellcell organelleorganelle membrane-enclosed lumenmembrane-enclosed lumen supramolecular complexsupramolecular complex
Pathways (from Reactome )Phenotype (from MGI , Zfin or HPO ) immune system phenotype hematopoietic system phenotype respiratory system phenotype cellular phenotype immune system phenotype hematopoietic system phenotype respiratory system phenotype cellular phenotype immune system phenotype hematopoietic system phenotype respiratory system phenotype cellular phenotype immune system phenotype hematopoietic system phenotype respiratory system phenotype cellular phenotype immune system phenotype hematopoietic system phenotype respiratory system phenotype cellular phenotype immune system phenotype hematopoietic system phenotype respiratory system phenotype cellular phenotype immune system phenotype hematopoietic system phenotype respiratory system phenotype cellular phenotype immune system phenotype hematopoietic system phenotype respiratory system phenotype cellular phenotype immune system phenotype hematopoietic system phenotype respiratory system phenotype cellular phenotype immune system phenotype hematopoietic system phenotype respiratory system phenotype cellular phenotype immune system phenotypeimmune system phenotype hematopoietic system phenotypehematopoietic system phenotype respiratory system phenotyperespiratory system phenotype cellular phenotypecellular phenotype MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ednrbtm1.1Nrd /Ednrb+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ednrbtm1.1Nrd /Ednrb+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ednrbtm1.1Nrd /Ednrb+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0003155 abnormal telomere length "abnormal length of the terminal section of a chromosome which has a specialized structure and which is involved in chromosomal replication and stability; normal length is a few hundred base pairs" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Ednrbtm1.1Nrd /Ednrb+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ednrbtm1.1Nrd /Ednrb+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0004029 spontaneous chromosome breakage "chromosome breakage due to inherent instability of chromosomes" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Ednrbtm1.1Nrd /Ednrb+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Interacting proteins (from Reactome )No match
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