ENSMUSG00000035262


Mus musculus

Features
Gene ID: ENSMUSG00000035262
  
Biological name :Amh
  
Synonyms : Amh / anti-Mullerian hormone
  
Possible biological names infered from orthology : P03971
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C1
Gene start: 80805243
Gene end: 80807648
  
Corresponding Affymetrix probe sets: 10364903 (MoGene1.0st)   1450573_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000043153
NCBI entrez gene - 11705     See in Manteia.
MGI - MGI:88006
RefSeq - NM_007445
RefSeq - XM_006513119
RefSeq Peptide - NP_031471
swissprot - Q5EC55
Ensembl - ENSMUSG00000035262
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 amhENSDARG00000014357Danio rerio
 AMHENSGALG00000036346Gallus gallus
 AMHENSG00000104899Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR006799  Anti-Mullerian hormone, N-terminal
 IPR017948  Transforming growth factor beta, conserved site
 IPR021203  Muellerian-inhibiting factor
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001546 preantral ovarian follicle growth IEA
 biological_processGO:0001655 urogenital system development IEA
 biological_processGO:0001880 Mullerian duct regression IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0008406 gonad development IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:2000355 negative regulation of ovarian follicle development IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IEA
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
Signaling by BMP


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001145 abnormal male reproductive anatomy "anomalous structure of the organs associated with producing offspring in the gender that produces spermatozoa" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Myl1tm1(cre)Sjb/Myl1+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001152 Leydig cell hyperplasia "increased number of interstitial cells of the seminiferous tubules that secrete testosterone" [J:45065]
Show

Allelic Composition: Myl1tm1(cre)Sjb/Myl1+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
Show

Allelic Composition: Amhtm1Bhr/Amhtm1Bhr,ArTfm/Y
Genetic Background: either: (involves 129P3/J * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0001749 suppressed circulating follicle stimulating hormone level "repression of secretion into the blood of FSH, the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [J:45065, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Myl1tm1(cre)Sjb/Myl1+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Amhtm1Bhr/Amhtm1Bhr,Amhr2tm1Bhr/Amhr2tm1Bhr
Genetic Background: Not Specified

 MP:0001939 secondary sex reversal "secondary sexual phenotype is not consistent with the chromosomal sex, i.e., internal and/or external genitalia are inconsistent with chromosomal sex " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myl1tm1(cre)Sjb/Myl1+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Amhtm1Bhr/Amhtm1Bhr,ArTfm/Y
Genetic Background: either: (involves 129P3/J * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)

Allelic Composition: Amhtm3.1Bhr/Amhtm3.1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Amhtm1Bhr/Amhtm1Bhr,Amhr2tm1Bhr/Amhr2tm1Bhr
Genetic Background: Not Specified

Allelic Composition: Amhtm1Bhr/Amh+,Amhr2tm1Bhr/Amhr2tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Amhtm2Bhr/Amhtm2Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Amhtm5Bhr/Amhtm5Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Amhtm4.1Bhr/Amhtm4.1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002212 abnormal secondary sex determination "gonadal development may or may not be normal, and the phenotype of the animal outside the gonad does not match chromosomal sex or is ambiguous" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myl1tm1(cre)Sjb/Myl1+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Amhtm2Bhr/Amhtm2.1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002286 cryptorchism "failure of one or both of the testes to descend into the scrotum around the time of birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Amhtm1Bhr/Amhtm1Bhr,ArTfm/Y
Genetic Background: either: (involves 129P3/J * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0002678 increased follicle recruitment 
Show

Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002789 male pseudohermaphroditism "pseudohermaphroditism in which the gonads are male (testes) and the karyotype is XY but the secondary sex characteristics are female-like or ambiguous" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myl1tm1(cre)Sjb/Myl1+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Amhtm1Bhr/Amhtm1Bhr,ArTfm/Y
Genetic Background: either: (involves 129P3/J * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)

Allelic Composition: Amhtm3.1Bhr/Amhtm3.1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Amhtm1Bhr/Amhtm1Bhr,Amhr2tm1Bhr/Amhr2tm1Bhr
Genetic Background: Not Specified

Allelic Composition: Amhtm1Bhr/Amh+,Amhr2tm1Bhr/Amhr2tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Amhtm2Bhr/Amhtm2Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Amhtm5Bhr/Amhtm5Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Amhtm4.1Bhr/Amhtm4.1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003557 absent vas deferens "absence of the secretory duct of the testicle that carries spermatozoa, running from the epididymis, of which it is the continuation, to the prostatic urethra where it terminates to form ejaculatory duct" [ncbi:Matthew Mailman, NCBI request, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Amhtm1Bhr/Amhtm1Bhr,ArTfm/Y
Genetic Background: either: (involves 129P3/J * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0004727 absent epididymis "absence of the elongated structure connected to the posterior surface of the testis, consisting of the head, body, and tail, which turns sharply on itself to become the ductus deferens (vas deferens)" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Amhtm1Bhr/Amhtm1Bhr,ArTfm/Y
Genetic Background: either: (involves 129P3/J * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0004855 increased ovary weight "greater average weight of the female reproductive gland containing the germ cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Amhtm1Bhr/Amhtm1Bhr,ArTfm/Y
Genetic Background: either: (involves 129P3/J * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)

Allelic Composition: Amhtm1Bhr/Amhtm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0006262 testis tumor "presence of abnormal rapidly proliferating cells in the testis, usually in the form of a distinct mass" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:60034]
Show

Allelic Composition: Amhtm1Bhr/Amh+,Amhr2tm1Bhr/Amhr2tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000023047 Amhr2 / Q8K592 / Mus musculus anti-Mullerian hormone type 2 receptor (Amhr2), transcript variant 2, mRNA. / Q16671* / anti-Mullerian hormone receptor type 2*  / complex / reaction
 ENSMUSG00000035262 Amh / anti-Mullerian hormone / P03971*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr