ENSMUSG00000035296


Mus musculus

Features
Gene ID: ENSMUSG00000035296
  
Biological name :Sgcg
  
Synonyms : P82348 / sarcoglycan, gamma (dystrophin-associated glycoprotein) / Sgcg
  
Possible biological names infered from orthology : Q13326 / sarcoglycan gamma
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: D1
Gene start: 61219115
Gene end: 61258490
  
Corresponding Affymetrix probe sets: 10420616 (MoGene1.0st)   1421254_a_at (Mouse Genome 430 2.0 Array)   1429823_at (Mouse Genome 430 2.0 Array)   1437523_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000077106
Ensembl peptide - ENSMUSP00000112576
NCBI entrez gene - 24053     See in Manteia.
MGI - MGI:1346524
RefSeq - XM_006519012
RefSeq - NM_011892
RefSeq Peptide - NP_036022
swissprot - P82348
swissprot - Q9EQ83
Ensembl - ENSMUSG00000035296
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sgcgENSDARG00000038107Danio rerio
 SGCGENSGALG00000017122Gallus gallus
 SGCGENSG00000102683Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sgcz / Q8BX51 / Zeta-sarcoglycan / Q96LD1* / sarcoglycan zeta*ENSMUSG0000003953955
Sgcd / P82347 / sarcoglycan, delta (dystrophin-associated glycoprotein) / Q92629* / sarcoglycan delta*ENSMUSG0000002035449


Protein motifs (from Interpro)
Interpro ID Name
 IPR006875  Sarcoglycan complex subunit protein
 IPR027660  Gamma-sarcoglycan


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007517 muscle organ development IBA
 biological_processGO:0048738 cardiac muscle tissue development IBA
 biological_processGO:0055001 muscle cell development IBA
 biological_processGO:0060047 heart contraction IBA
 biological_processGO:0061024 membrane organization TAS
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016011 dystroglycan complex IDA
 cellular_componentGO:0016012 sarcoglycan complex IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0042383 sarcolemma IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000069 kyphoscoliosis "kyphosis combined with scoliosis" [MGI:CML, J:66943]
Show

Allelic Composition: Itga7tm1Umr/Itga7tm1Umr,Sgcgtm1Mcn/Sgcgtm1Mcn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000249 abnormal blood vessel physiology "anomalous function of any of the tubes that convey blood: arteries, arterioles, capallaries, venules, veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Csrp3tm1Crni/Csrp3tm1Crni,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129S2/SvPas * CF1

 MP:0000748 progressive muscle weakness "increasing loss of strength over time" [MGI:CLS, J:67994]
Show

Allelic Composition: Sgcgtm1Oza/Sgcgtm1Oza
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000749 muscle degeneration "pathological deterioration of muscle tissue, often accompanied by loss of function" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptpn1tm1Bbk/Ptpn1tm1Bbk
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Sgcgtm1Oza/Sgcgtm1Oza
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000750 abnormal muscle regeneration "inability or defects in ability to repair muscle after injuries" [J:42574]
Show

Allelic Composition: Sgcgtm1Oza/Sgcgtm1Oza
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000752 dystrophic muscle "progressive weakness and wasting of muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67994]
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Allelic Composition: Csrp3tm1Crni/Csrp3tm1Crni,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129S2/SvPas * CF1

Allelic Composition: Sgcgtm1Oza/Sgcgtm1Oza
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Csrp3tm1Crni/Csrp3tm1Crni,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129S2/SvPas * CF1

 MP:0001388 abnormal stationary movement "altered ability or inability to change body posture or shift a body part" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptpn1tm1Bbk/Ptpn1tm1Bbk
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Csrp3tm1Crni/Csrp3tm1Crni,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129S2/SvPas * CF1

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Csrp3tm1Crni/Csrp3tm1Crni,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129S2/SvPas * CF1

Allelic Composition: Itga7tm1Umr/Itga7tm1Umr,Sgcgtm1Mcn/Sgcgtm1Mcn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001442 decreased grooming behavior "reduced amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptpn1tm1Bbk/Ptpn1tm1Bbk
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Itga7tm1Umr/Itga7tm1Umr,Sgcgtm1Mcn/Sgcgtm1Mcn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Csrp3tm1Crni/Csrp3tm1Crni,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129S2/SvPas * CF1

Allelic Composition: Sgcgtm1Oza/Sgcgtm1Oza
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Paqr3tm1Ychn/Paqr3+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Ltbp4dmod1-DBA/2J/Ltbp4dmod1-DBA/2J,Sgcgtm1Mcn/Sgcgtm1Mcn
Genetic Background: D2.Cg-Ltbp4dmod1-DBA/2J Sgcgtm1Mcn

 MP:0002279 abnormal diaphragm morphology "structural defect in the thin musculomebraneous barrier that separates the abdominal and thoracic cavities; these muscles often used for breathing control" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Csrp3tm1Crni/Csrp3tm1Crni,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129S2/SvPas * CF1

Allelic Composition: Sgcgtm1Oza/Sgcgtm1Oza
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002834 decreased heart weight "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Csrp3tm1Crni/Csrp3tm1Crni,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129S2/SvPas * CF1

 MP:0002953 thick ventricular wall "increased depth of the cardiac wall of the heart ventricles" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Csrp3tm1Crni/Csrp3tm1Crni,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129S2/SvPas * CF1

 MP:0003083 abnormal tibialis anterior morphology "anomaly in the the muscle of the shin that is responsible for dorsiflexion and inversion of the foot" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Sgcgtm1Oza/Sgcgtm1Oza
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sgcgtm1Oza/Sgcgtm1Oza
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003851 skeletal muscle interstitial fibrosis "formation of fibrous tissue within the interstices of skeletal muscle as a result of repair or a reactive process" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Sgcgtm1Oza/Sgcgtm1Oza
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003852 skeletal muscle necrosis "pathological cell death in the skeletal muscle, usually due to irreversible damage" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Sgcgtm1Oza/Sgcgtm1Oza
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004818 increased skeletal muscle mass "increase in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sgcgtm1Oza/Sgcgtm1Oza
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Csrp3tm1Crni/Csrp3tm1Crni,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129S2/SvPas * CF1

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Itga7tm1Umr/Itga7tm1Umr,Sgcgtm1Mcn/Sgcgtm1Mcn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Itga7tm1Umr/Itga7tm1Umr,Sgcgtm1Mcn/Sgcgtm1Mcn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006085 myocardial necrosis "pathological cell death of the cardiac muscle cells, usually due to irreversible damage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92722]
Show

Allelic Composition: Sgcgtm1Oza/Sgcgtm1Oza
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009399 increased skeletal muscle fiber size "increase in the size of the large multinucleated cells that make up the skeletal muscles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sgcgtm1Oza/Sgcgtm1Oza
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009419 skeletal muscle fibrosis "formation of fibrous tissue within skeletal muscle as a result of repair or a reactive process" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Paqr3tm1Ychn/Paqr3+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Ltbp4dmod1-DBA/2J/Ltbp4dmod1-DBA/2J,Sgcgtm1Mcn/Sgcgtm1Mcn
Genetic Background: D2.Cg-Ltbp4dmod1-DBA/2J Sgcgtm1Mcn

 MP:0009461 skeletal muscle hypertrophy "increase in the bulk size of the skeletal muscle due to cell enlargement" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Sgcgtm1Oza/Sgcgtm1Oza
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0010052 increased grip strength "greater ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Paqr3tm1Ychn/Paqr3+
Genetic Background: involves: 129 * C57BL/6J

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Ltbp4dmod1-DBA/2J/Ltbp4dmod1-DBA/2J,Sgcgtm1Mcn/Sgcgtm1Mcn
Genetic Background: D2.Cg-Ltbp4dmod1-DBA/2J Sgcgtm1Mcn

 MP:0010090 increased circulating creatine kinase level "an elevation in the concentration in the blood of an enzyme that catalyzes the reversible transfer of creatine to phosphocreatine" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Csrp3tm1Crni/Csrp3tm1Crni,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129S2/SvPas * CF1

Allelic Composition: Sgcgtm1Oza/Sgcgtm1Oza
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011083 complete lethality at weaning "premature death at weaning age of all organisms of a given genotype in a population, often due to the inability to make the transition to solid food" [MGI:csmith]
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Allelic Composition: Itga7tm1Umr/Itga7tm1Umr,Sgcgtm1Mcn/Sgcgtm1Mcn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0012059 thick diaphragm muscle "increased thickness of the diaphragm muscle" [MGI:smb]
Show

Allelic Composition: Csrp3tm1Crni/Csrp3tm1Crni,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129S2/SvPas * CF1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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