ENSMUSG00000020354


Mus musculus

Features
Gene ID: ENSMUSG00000020354
  
Biological name :Sgcd
  
Synonyms : P82347 / sarcoglycan, delta (dystrophin-associated glycoprotein) / Sgcd
  
Possible biological names infered from orthology : Q92629 / sarcoglycan delta
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B1.1
Gene start: 46896253
Gene end: 47988969
  
Corresponding Affymetrix probe sets: 10385466 (MoGene1.0st)   1450805_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000076459
Ensembl peptide - ENSMUSP00000104843
NCBI entrez gene - 24052     See in Manteia.
MGI - MGI:1346525
RefSeq - XM_011249013
RefSeq - NM_011891
RefSeq - XM_006533306
RefSeq - XM_006533307
RefSeq - XM_011249012
RefSeq Peptide - NP_036021
swissprot - A2ACH6
swissprot - P82347
swissprot - Q544D4
Ensembl - ENSMUSG00000020354
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sgcdENSDARG00000098573Danio rerio
 SGCDENSGALG00000003886Gallus gallus
 SGCDENSG00000170624Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sgcz / Q8BX51 / Zeta-sarcoglycan / Q96LD1* / sarcoglycan zeta*ENSMUSG0000003953958
Sgcg / P82348 / sarcoglycan, gamma (dystrophin-associated glycoprotein) / Q13326* / sarcoglycan gamma*ENSMUSG0000003529649


Protein motifs (from Interpro)
Interpro ID Name
 IPR006875  Sarcoglycan complex subunit protein
 IPR027661  Delta-sarcoglycan


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007517 muscle organ development IBA
 biological_processGO:0048738 cardiac muscle tissue development IBA
 biological_processGO:0055001 muscle cell development IBA
 biological_processGO:0060047 heart contraction IBA
 biological_processGO:0061024 membrane organization TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016010 dystrophin-associated glycoprotein complex IEA
 cellular_componentGO:0016011 dystroglycan complex IDA
 cellular_componentGO:0016012 sarcoglycan complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0042383 sarcolemma IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Selltm1Tft/Selltm1Tft
Genetic Background: B6.129-Selltm1Tft

 MP:0000749 muscle degeneration "pathological deterioration of muscle tissue, often accompanied by loss of function" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sgcdtm1Mcn/Sgcdtm1Mcn
Genetic Background: involves: 129S1/Sv * 129T2/SvEmsJ * 129X1/SvJ

 MP:0000752 dystrophic muscle "progressive weakness and wasting of muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67994]
Show

Allelic Composition: Selltm1Tft/Selltm1Tft
Genetic Background: B6.129-Selltm1Tft

Allelic Composition: Sgcdtm1Mcn/Sgcdtm1Mcn
Genetic Background: involves: 129S1/Sv * 129T2/SvEmsJ * 129X1/SvJ

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Selltm1Tft/Selltm1Tft
Genetic Background: B6.129-Selltm1Tft

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Selltm1Tft/Selltm1Tft
Genetic Background: B6.129-Selltm1Tft

Allelic Composition: Sgcdtm1Mcn/Sgcdtm1Mcn
Genetic Background: involves: 129S1/Sv * 129T2/SvEmsJ * 129X1/SvJ

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sgcdtm1Mcn/Sgcdtm1Mcn
Genetic Background: involves: 129S1/Sv * 129T2/SvEmsJ * 129X1/SvJ

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Selltm1Tft/Selltm1Tft
Genetic Background: B6.129-Selltm1Tft

Allelic Composition: Sgcdtm1Ojml/Sgcd+
Genetic Background: B6.129-Sgcdtm1Ojml

Allelic Composition: Sgcdtm1Mcn/Sgcdtm1Mcn
Genetic Background: B6.129-Sgcdtm1Mcn/J

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Sgcdtm1Ojml/Sgcd+
Genetic Background: B6.129-Sgcdtm1Ojml

 MP:0002837 dystrophic cardiac calcinosis "a condition characterized by the localized deposition of calcium salts in the heart; often occuring in association with inflammation or atherosclerotic lesions and other pathological states" [J:76777, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Selltm1Tft/Selltm1Tft
Genetic Background: B6.129-Selltm1Tft

 MP:0003024 coronary stenosis "constriction or narrowing of any of the blood vessels supplying the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Selltm1Tft/Selltm1Tft
Genetic Background: B6.129-Selltm1Tft

 MP:0003061 decreased aerobic running capacity "reduced ability to run at defined speeds and/or distances compared to controls" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Sgcdtm1Ojml/Sgcd+
Genetic Background: B6.129-Sgcdtm1Ojml

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Selltm1Tft/Selltm1Tft
Genetic Background: B6.129-Selltm1Tft

Allelic Composition: Sgcdtm1Mcn/Sgcdtm1Mcn
Genetic Background: B6.129-Sgcdtm1Mcn/J

 MP:0003852 skeletal muscle necrosis "pathological cell death in the skeletal muscle, usually due to irreversible damage" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Selltm1Tft/Selltm1Tft
Genetic Background: B6.129-Selltm1Tft

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sgcdtm1Ojml/Sgcd+
Genetic Background: B6.129-Sgcdtm1Ojml

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Selltm1Tft/Selltm1Tft
Genetic Background: B6.129-Selltm1Tft

 MP:0005330 cardiomyopathy "diseases of the heart (myocardium); may result from many causes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80681]
Show

Allelic Composition: Selltm1Tft/Selltm1Tft
Genetic Background: B6.129-Selltm1Tft

Allelic Composition: Sgcdtm1Mcn/Sgcdtm1Mcn
Genetic Background: involves: 129S1/Sv * 129T2/SvEmsJ * 129X1/SvJ

 MP:0005620 abnormal muscle contractility "aberrant ability of a muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sgcdtm1Mcn/Sgcdtm1Mcn
Genetic Background: involves: 129S1/Sv * 129T2/SvEmsJ * 129X1/SvJ

 MP:0006085 myocardial necrosis "pathological cell death of the cardiac muscle cells, usually due to irreversible damage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92722]
Show

Allelic Composition: Selltm1Tft/Selltm1Tft
Genetic Background: B6.129-Selltm1Tft

 MP:0009416 cardiac muscle degeneration "pathological deterioration of cardiac muscle tissue, often accompanied by loss of function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sgcdtm1Mcn/Sgcdtm1Mcn
Genetic Background: B6.129-Sgcdtm1Mcn/J

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Selltm1Tft/Selltm1Tft
Genetic Background: B6.129-Selltm1Tft

 MP:0010090 increased circulating creatine kinase level "an elevation in the concentration in the blood of an enzyme that catalyzes the reversible transfer of creatine to phosphocreatine" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sgcdtm1Mcn/Sgcdtm1Mcn
Genetic Background: involves: 129S1/Sv * 129T2/SvEmsJ * 129X1/SvJ

 MP:0010394 decreased QRS amplitude "reduction in the size (height or maximum displacement) of the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction, suggesting ventricular excitation defects" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Selltm1Tft/Selltm1Tft
Genetic Background: B6.129-Selltm1Tft

 MP:0010632 cardiac muscle necrosis "pathological death of cardiomyocytes or a portion of the cardiac muscle tissue; usually due to irreversible damage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sgcdtm1Mcn/Sgcdtm1Mcn
Genetic Background: B6.129-Sgcdtm1Mcn/J

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Cdk5rap2Gt(RRO242)Byg/Cdk5rap2an
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011749 perivascular fibrosis "invasion of fibrous connective tissue into the perivascular tissue, often resulting from inflammation or injury" [MGI:csmith]
Show

Allelic Composition: Sgcdtm1Mcn/Sgcdtm1Mcn
Genetic Background: involves: 129S1/Sv * 129T2/SvEmsJ * 129X1/SvJ

 MP:0012735 abnormal response to exercise "any anomaly in the physiological changes induced by controlled exercise" [MPD:Molly]
Show

Allelic Composition: Sgcdtm1Ojml/Sgcd+
Genetic Background: B6.129-Sgcdtm1Ojml

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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