ENSMUSG00000035528


Mus musculus

Features
Gene ID: ENSMUSG00000035528
  
Biological name :Npffr2
  
Synonyms : Neuropeptide FF receptor 2 / Npffr2 / Q924H0
  
Possible biological names infered from orthology : Q9Y5X5
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: E1
Gene start: 89527429
Gene end: 89583740
  
Corresponding Affymetrix probe sets: 10523048 (MoGene1.0st)   1422214_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000040033
NCBI entrez gene - 104443     See in Manteia.
MGI - MGI:1860130
RefSeq - NM_133192
RefSeq - XM_017320589
RefSeq Peptide - NP_573455
swissprot - Q924H0
Ensembl - ENSMUSG00000035528
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NPFFR2ENSDARG00000033635Danio rerio
 npffr2bENSDARG00000060702Danio rerio
 NPFFR2ENSGALG00000011616Gallus gallus
 NPFFR2ENSG00000056291Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Npffr1 / neuropeptide FF receptor 1 / Q9GZQ6*ENSMUSG0000002009047
Hcrtr2 / P58308 / Orexin receptor type 2 / O43614* / hypocretin receptor 2*ENSMUSG0000003236029
Hcrtr1 / P58307 / Orexin receptor type 1 / O43613* / hypocretin receptor 1*ENSMUSG0000002877828
Cckar / O08786 / Cholecystokinin receptor type A / P32238* / cholecystokinin A receptor*ENSMUSG0000002919327
C130060K24Rik / RIKEN cDNA C130060K24 gene / QRFPR* / Q96P65* / pyroglutamylated RFamide peptide receptor*ENSMUSG0000002991726
Qrfpr / P83861 / pyroglutamylated RFamide peptide receptor / Q96P65*ENSMUSG0000005840026
Galr1 / P56479 / Galanin receptor type 1 / P47211* / galanin receptor 1*ENSMUSG0000002455323
Galr2 / O88854 / Galanin receptor type 2 / O43603* / galanin receptor 2*ENSMUSG0000002079322
Cckbr / P56481 / Gastrin/cholecystokinin type B receptor / P32239* / cholecystokinin B receptor*ENSMUSG0000003089821
Kiss1r / Q91V45 / Mus musculus KISS1 receptor (Kiss1r), transcript variant 2, mRNA. / Q969F8* / KISS1 receptor*ENSMUSG0000003577320
Galr3 / O88853 / Galanin receptor type 3 / O60755* / galanin receptor 3*ENSMUSG0000011475520


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR005395  Neuropeptide FF receptor family
 IPR005397  Neuropeptide FF receptor, type 2
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway ISS
 biological_processGO:0007218 neuropeptide signaling pathway IEA
 biological_processGO:0032870 cellular response to hormone stimulus IBA
 biological_processGO:0043408 regulation of MAPK cascade IEA
 biological_processGO:0045761 regulation of adenylate cyclase activity IEA
 biological_processGO:1901652 response to peptide IBA
 biological_processGO:2000479 regulation of cAMP-dependent protein kinase activity IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0015629 actin cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IBA
 molecular_functionGO:0008188 neuropeptide receptor activity IEA
 molecular_functionGO:0031628 opioid receptor binding IEA
 molecular_functionGO:0042277 peptide binding IBA


Pathways (from Reactome)
Pathway description
Orexin and neuropeptides FF and QRFP bind to their respective receptors
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000023052 Npff / Q9WVA8 / Pro-FMRFamide-related neuropeptide FF Neuropeptide SF Neuropeptide FF Neuropeptide AF-like / O15130* / neuropeptide FF-amide peptide precursor*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr