ENSMUSG00000032360


Mus musculus

Features
Gene ID: ENSMUSG00000032360
  
Biological name :Hcrtr2
  
Synonyms : Hcrtr2 / Orexin receptor type 2 / P58308
  
Possible biological names infered from orthology : hypocretin receptor 2 / O43614
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: D
Gene start: 76225880
Gene end: 76323856
  
Corresponding Affymetrix probe sets: 10595059 (MoGene1.0st)   1444223_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000058230
Ensembl peptide - ENSMUSP00000139377
NCBI entrez gene - 387285     See in Manteia.
MGI - MGI:2680765
RefSeq - NM_198962
RefSeq Peptide - NP_945200
swissprot - P58308
Ensembl - ENSMUSG00000032360
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hcrtr2ENSDARG00000023722Danio rerio
 HCRTR2ENSGALG00000016297Gallus gallus
 HCRTR2ENSG00000137252Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hcrtr1 / P58307 / Orexin receptor type 1 / O43613* / hypocretin receptor 1*ENSMUSG0000002877862
Npffr1 / neuropeptide FF receptor 1 / Q9GZQ6*ENSMUSG0000002009028
Npffr2 / Q924H0 / Neuropeptide FF receptor 2 / Q9Y5X5*ENSMUSG0000003552826
Cckbr / P56481 / Gastrin/cholecystokinin type B receptor / P32239* / cholecystokinin B receptor*ENSMUSG0000003089823
Cckar / O08786 / Cholecystokinin receptor type A / P32238* / cholecystokinin A receptor*ENSMUSG0000002919322
Qrfpr / P83861 / pyroglutamylated RFamide peptide receptor / Q96P65*ENSMUSG0000005840022
C130060K24Rik / RIKEN cDNA C130060K24 gene / QRFPR* / Q96P65* / pyroglutamylated RFamide peptide receptor*ENSMUSG0000002991721
Galr1 / P56479 / Galanin receptor type 1 / P47211* / galanin receptor 1*ENSMUSG0000002455319
Kiss1r / Q91V45 / Mus musculus KISS1 receptor (Kiss1r), transcript variant 2, mRNA. / Q969F8* / KISS1 receptor*ENSMUSG0000003577319
Galr2 / O88854 / Galanin receptor type 2 / O43603* / galanin receptor 2*ENSMUSG0000002079318
Galr3 / O88853 / Galanin receptor type 3 / O60755* / galanin receptor 3*ENSMUSG0000011475516


Protein motifs (from Interpro)
Interpro ID Name
 IPR000204  Orexin receptor family
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR004060  Orexin receptor 2
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007218 neuropeptide signaling pathway ISO
 biological_processGO:0007631 feeding behavior IBA
 biological_processGO:0010840 regulation of circadian sleep/wake cycle, wakefulness ISS
 biological_processGO:0022410 circadian sleep/wake cycle process IEA
 biological_processGO:0032870 cellular response to hormone stimulus IBA
 biological_processGO:0045187 regulation of circadian sleep/wake cycle, sleep IBA
 biological_processGO:0051480 regulation of cytosolic calcium ion concentration ISS
 biological_processGO:1901652 response to peptide IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016499 orexin receptor activity ISO
 molecular_functionGO:0017046 peptide hormone binding IEA
 molecular_functionGO:0042277 peptide binding IBA


Pathways (from Reactome)
Pathway description
Orexin and neuropeptides FF and QRFP bind to their respective receptors
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001501 abnormal sleep pattern "deviation from the normal wake/sleep cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptstm1Ich/Ptstm1Ich
Genetic Background: B6.129X1-Ptstm1Ich

 MP:0003360 depression-related behavior 
Show

Allelic Composition: Hcrtr2tm1Tesc/Hcrtr2tm1Tesc
Genetic Background: B6.Cg-Hcrtr2tm1Tesc

 MP:0004142 abnormal muscle tone "anomaly in the resting tautness or laxity of a muscle, normally somewhere in the middle of the range between total contraction and total relaxation" [hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hcrtr2tm1Tesc/Hcrtr2tm1Tesc
Genetic Background: B6.Cg-Hcrtr2tm1Tesc

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Hcrtr2tm1Tesc/Hcrtr2tm1Tesc
Genetic Background: B6.Cg-Hcrtr2tm1Tesc

 MP:0005279 narcolepsy "recurring episodes of sleep during normal waking hours and often disrupted sleep during normal sleeping period; often accompanied by catplexy, sleep paralysis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83817]
Show

Allelic Composition: Ptstm1Ich/Ptstm1Ich
Genetic Background: B6.129X1-Ptstm1Ich

Allelic Composition: Hcrtr2tm1Tesc/Hcrtr2tm1Tesc
Genetic Background: B6.Cg-Hcrtr2tm1Tesc

 MP:0009436 fragmentation of sleep/wake states "short bouts of sleep/wake stages with an increased number of transitions among these stages compared to controls" [PMID:19246384]
Show

Allelic Composition: Hcrtr2tm1Tesc/Hcrtr2tm1Tesc
Genetic Background: B6.Cg-Hcrtr2tm1Tesc

Allelic Composition: Hcrtr2tm1Tesc/Hcrtr2tm1Tesc
Genetic Background: B6.129-Hcrtr2tm1Tesc

 MP:0012288 abnormal paradoxical sleep pattern "any anomaly in the frequency or duration of the sleep stage in which dreams occur and the body undergoes marked changes including rapid eye movement, loss of reflexes, and increased pulse rate and brain activity" [MGI:csmith]
Show

Allelic Composition: Ptstm1Ich/Ptstm1Ich
Genetic Background: B6.129X1-Ptstm1Ich

 MP:0012289 abnormal non-rapid eye movement sleep pattern "any anomaly in the frequency or duration of the sleep stages characterized by distinct EEG patterns, decreased metabolic activity, slowed breathing and heart rate, and the absence of rapid eye movement and dreaming" [MGI:csmith]
Show

Allelic Composition: Ptstm1Ich/Ptstm1Ich
Genetic Background: B6.129X1-Ptstm1Ich

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000045471 Hcrt / O55241 / Orexin Orexin-A Orexin-B / O43612* / hypocretin neuropeptide precursor*  / complex / reaction






 

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