ENSMUSG00000045471


Mus musculus

Features
Gene ID: ENSMUSG00000045471
  
Biological name :Hcrt
  
Synonyms : Hcrt / O55241 / Orexin Orexin-A Orexin-B
  
Possible biological names infered from orthology : hypocretin neuropeptide precursor / O43612
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: D
Gene start: 100761069
Gene end: 100762931
  
Corresponding Affymetrix probe sets: 10391273 (MoGene1.0st)   1420471_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000102983
Ensembl peptide - ENSMUSP00000057578
NCBI entrez gene - 15171     See in Manteia.
MGI - MGI:1202306
RefSeq - NM_010410
RefSeq Peptide - NP_034540
swissprot - A2A5D9
swissprot - O55241
swissprot - Q547R2
Ensembl - ENSMUSG00000045471
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hcrtENSDARG00000070932Danio rerio
 HCRTENSGALG00000011485Gallus gallus
 HCRTENSG00000161610Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001704  Prepro-orexin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001659 temperature homeostasis IEA
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007218 neuropeptide signaling pathway IEA
 biological_processGO:0007631 feeding behavior IEA
 biological_processGO:0008156 negative regulation of DNA replication IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0042755 eating behavior IEA
 biological_processGO:0043267 negative regulation of potassium ion transport IEA
 biological_processGO:0046928 regulation of neurotransmitter secretion IEA
 biological_processGO:0051928 positive regulation of calcium ion transport IEA
 biological_processGO:0051970 negative regulation of transmission of nerve impulse IEA
 biological_processGO:0051971 positive regulation of transmission of nerve impulse IEA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005791 rough endoplasmic reticulum IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030141 secretory granule IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0098794 postsynapse IEA
 molecular_functionGO:0005184 neuropeptide hormone activity IEA
 molecular_functionGO:0031771 type 1 hypocretin receptor binding IEA
 molecular_functionGO:0031772 type 2 hypocretin receptor binding IEA


Pathways (from Reactome)
Pathway description
Orexin and neuropeptides FF and QRFP bind to their respective receptors
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000230 abnormal blood pressure "altered tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mdm2tm1Ypz/Mdm2tm1Ypz
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mdm2tm1Ypz/Mdm2tm1Ypz
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Mdm2tm1Ypz/Mdm2tm1Ypz
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

Allelic Composition: Hcrttm1Ywa/Hcrttm1Ywa
Genetic Background: B6.129S6-Hcrttm1Ywa

Allelic Composition: Hcrttm1.1(KOMP)Vlcg/Hcrttm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Hcrttm1.1(KOMP)Vlcg/Ucd

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Mdm2tm1Ypz/Mdm2tm1Ypz
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

Allelic Composition: Hcrttm1Ywa/Hcrttm1Ywa
Genetic Background: involves: 129S6/SvEvTac

 MP:0001501 abnormal sleep pattern "deviation from the normal wake/sleep cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mdm2tm1Ypz/Mdm2tm1Ypz
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

Allelic Composition: Hcrttm1Ywa/Hcrttm1Ywa
Genetic Background: involves: 129S6/SvEvTac

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
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Allelic Composition: Mdm2tm1Ypz/Mdm2tm1Ypz
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mdm2tm1Ypz/Mdm2tm1Ypz
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0002574 increased vertical activity "greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Mdm2tm1Ypz/Mdm2tm1Ypz
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0002626 increased heart rate "greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Mdm2tm1Ypz/Mdm2tm1Ypz
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Hcrttm1.1(KOMP)Vlcg/Hcrttm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Hcrttm1.1(KOMP)Vlcg/Ucd

 MP:0003212 susceptibility to age related obesity "increased probability of excessive weight gain that is progressive with age" [RGD:Rat Genome Database submission]
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Allelic Composition: Mdm2tm1Ypz/Mdm2tm1Ypz
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

Allelic Composition: Hcrttm1Ywa/Hcrt+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mdm2tm1Ypz/Mdm2tm1Ypz
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0004142 abnormal muscle tone "anomaly in the resting tautness or laxity of a muscle, normally somewhere in the middle of the range between total contraction and total relaxation" [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Hcrttm1Ywa/Hcrttm1Ywa
Genetic Background: involves: 129S6/SvEvTac

 MP:0004876 decreased mean arterial blood pressure "decrease in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mdm2tm1Ypz/Mdm2tm1Ypz
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hcrttm1.1(KOMP)Vlcg/Hcrttm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Hcrttm1.1(KOMP)Vlcg/Ucd

 MP:0005279 narcolepsy "recurring episodes of sleep during normal waking hours and often disrupted sleep during normal sleeping period; often accompanied by catplexy, sleep paralysis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83817]
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Allelic Composition: Mdm2tm1Ypz/Mdm2tm1Ypz
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

Allelic Composition: Hcrttm1Ywa/Hcrttm1Ywa
Genetic Background: involves: 129S6/SvEvTac

 MP:0005573 increased breathing frequency "greater than the normal number of breaths in a given period of time" [RGD:Rat Genome Database submission]
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Allelic Composition: Mdm2tm1Ypz/Mdm2tm1Ypz
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0008035 behavioral arrest "locomotor activity is interrupted by sudden periods of no movement" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Mdm2tm1Ypz/Mdm2tm1Ypz
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0009436 fragmentation of sleep/wake states "short bouts of sleep/wake stages with an increased number of transitions among these stages compared to controls" [PMID:19246384]
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Allelic Composition: Hcrttm1Ywa/Hcrttm1Ywa
Genetic Background: involves: 129S6/SvEvTac

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Hcrttm1.1(KOMP)Vlcg/Hcrttm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Hcrttm1.1(KOMP)Vlcg/Ucd

 MP:0011020 abnormal circadian temperature homeostasis "any anomaly in the process in which an organism modulates its internal body temperature at different values with a regularity of approximately 24 hours" [GO:0060086]
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Allelic Composition: Hcrttm1Ywa/Hcrttm1Ywa
Genetic Background: B6.129S6-Hcrttm1Ywa

 MP:0012287 increased frequency of paradoxical sleep "increased incidence or duration of the sleep stage in which dreams occur and the body undergoes marked changes including rapid eye movement, loss of reflexes, and increased pulse rate and brain activity" [http://orcid.org/0000-0001-5208-3432]
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Allelic Composition: Hcrttm1Ywa/Hcrttm1Ywa
Genetic Background: involves: 129S6/SvEvTac

 MP:0012288 abnormal paradoxical sleep pattern "any anomaly in the frequency or duration of the sleep stage in which dreams occur and the body undergoes marked changes including rapid eye movement, loss of reflexes, and increased pulse rate and brain activity" [MGI:csmith]
Show

Allelic Composition: Hcrttm1Ywa/Hcrttm1Ywa
Genetic Background: involves: 129S6/SvEvTac

 MP:0012289 abnormal non-rapid eye movement sleep pattern "any anomaly in the frequency or duration of the sleep stages characterized by distinct EEG patterns, decreased metabolic activity, slowed breathing and heart rate, and the absence of rapid eye movement and dreaming" [MGI:csmith]
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Allelic Composition: Hcrttm1Ywa/Hcrttm1Ywa
Genetic Background: involves: 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028778 Hcrtr1 / P58307 / Orexin receptor type 1 / O43613* / hypocretin receptor 1*  / complex / reaction
 ENSMUSG00000032360 Hcrtr2 / P58308 / Orexin receptor type 2 / O43614* / hypocretin receptor 2*  / complex / reaction






 

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