MP:0001260 | increased body weight | "greater than normal average weight " [J:33400] |
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Allelic Composition: Smad4tm1.1Gsu/Smad4tm1.1Gsu,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(MtTGFA)Lmb/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
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MP:0001261 | obese | "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator] |
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Allelic Composition: Smad4tm1.1Gsu/Smad4tm1.1Gsu,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(MtTGFA)Lmb/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
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MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
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Allelic Composition: Smad4tm1.1Gsu/Smad4tm1.1Gsu,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(MtTGFA)Lmb/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
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MP:0001326 | retinal degeneration | "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator] |
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Allelic Composition: Smad4tm1.1Gsu/Smad4tm1.1Gsu,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(MtTGFA)Lmb/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
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MP:0001433 | polyphagia | "eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Smad4tm1.1Gsu/Smad4tm1.1Gsu,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(MtTGFA)Lmb/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
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MP:0001762 | polyuria | "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Smad4tm1.1Gsu/Smad4tm1.1Gsu,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(MtTGFA)Lmb/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
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MP:0002959 | increased microalbumin excretion | "greater than the normal amount of fragments of this protein voided by the kidneys" [RGD:Rat Genome Database submission] |
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Allelic Composition: Smad4tm1.1Gsu/Smad4tm1.1Gsu,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(MtTGFA)Lmb/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
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MP:0003729 | abnormal photoreceptor outer segments | "malformation/anomalous structure of the photoreceptor layer which contains stacks of membranous discs that are rich in the visual pigment rhodopsin " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Smad4tm1.1Gsu/Smad4tm1.1Gsu,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(MtTGFA)Lmb/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
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MP:0004021 | abnormal rod electrophysiology | "anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Smad4tm1.1Gsu/Smad4tm1.1Gsu,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(MtTGFA)Lmb/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
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MP:0005291 | abnormal glucose tolerance | "deviation from the normal response to oral consumption or intravenous injection of specified amounts of glucose; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Smad4tm1.1Gsu/Smad4tm1.1Gsu,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(MtTGFA)Lmb/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
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MP:0005610 | increased circulating antidiuretic hormone level | "greater than the normal concentration of this peptide hormone in the blood; it is normally released by the neurohypophysis to control water metabolism and balance by regulating water loss; it also contracts smooth muscle" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Smad4tm1.1Gsu/Smad4tm1.1Gsu,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(MtTGFA)Lmb/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
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MP:0005669 | increased circulating leptin level | "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751] |
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Allelic Composition: Smad4tm1.1Gsu/Smad4tm1.1Gsu,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(MtTGFA)Lmb/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
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MP:0006072 | abnormal retinal apoptosis | "increase or decrease in the number of cells in the retina undergoing programmed cell death" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92622:] |
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Allelic Composition: Smad4tm1.1Gsu/Smad4tm1.1Gsu,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(MtTGFA)Lmb/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
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MP:0008138 | absent podocyte foot process | "absence of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Smad4tm1.1Gsu/Smad4tm1.1Gsu,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(MtTGFA)Lmb/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
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MP:0008450 | retinal photoreceptor degeneration | "a retrogressive impairment of function or destruction of a cell specialized to detect and transduce light, including rods and cones of the retina" [MESH:A08.663.650.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Smad4tm1.1Gsu/Smad4tm1.1Gsu,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(MtTGFA)Lmb/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
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MP:0008518 | retinal outer nuclear layer degeneration | "a retrogressive impairment or destruction of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Smad4tm1.1Gsu/Smad4tm1.1Gsu,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(MtTGFA)Lmb/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
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MP:0008580 | photoreceptor inner segment degeneration | "retrogressive pathologic change in the photoreceptor region which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc) and where opsin molecules are assembled and passed to be part of the outer segment region" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Smad4tm1.1Gsu/Smad4tm1.1Gsu,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(MtTGFA)Lmb/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
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MP:0008584 | photoreceptor outer segment degeneration | "retrogressive pathologic change in the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Smad4tm1.1Gsu/Smad4tm1.1Gsu,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(MtTGFA)Lmb/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
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MP:0009640 | abnormal renal tubule epithelium morphology | "any structural anomaly of the cellular avascular layer of the renal tubule luminar surfaces" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Smad4tm1.1Gsu/Smad4tm1.1Gsu,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(MtTGFA)Lmb/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
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MP:0011100 | complete preweaning lethality | "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith] |
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Allelic Composition: Mbpshi-mld/Mbpshi-mld Genetic Background: MDB/Dt
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MP:0011431 | increased urine flow rate | "increased volume of urine produced in a specified period of time" [MGI:anna] |
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Allelic Composition: Smad4tm1.1Gsu/Smad4tm1.1Gsu,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(MtTGFA)Lmb/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
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MP:0011859 | decreased renal glomerulus basement membrane thickness | "reduced width of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule" [MGI:anna] |
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Allelic Composition: Smad4tm1.1Gsu/Smad4tm1.1Gsu,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(MtTGFA)Lmb/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
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MP:0011965 | decreased total retina thickness | "decreased width of the retina through the center plane" [MGI:csmith] |
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Allelic Composition: Smad4tm1.1Gsu/Smad4tm1.1Gsu,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(MtTGFA)Lmb/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
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