ENSMUSG00000035930


Mus musculus

Features
Gene ID: ENSMUSG00000035930
  
Biological name :Chst4
  
Synonyms : carbohydrate sulfotransferase 4 / Chst4
  
Possible biological names infered from orthology : Q8NCG5
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: D3
Gene start: 110029153
Gene end: 110039740
  
Corresponding Affymetrix probe sets: 10581650 (MoGene1.0st)   1453393_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000104845
Ensembl peptide - ENSMUSP00000148756
Ensembl peptide - ENSMUSP00000148741
NCBI entrez gene - 26887     See in Manteia.
MGI - MGI:1349479
RefSeq - XM_006531045
RefSeq - NM_011998
RefSeq - XM_006531043
RefSeq - XM_006531044
RefSeq Peptide - NP_036128
swissprot - A0A0R4J1C9
swissprot - A0A1D5RME2
swissprot - A0A1D5RMF5
Ensembl - ENSMUSG00000035930
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CHST6ENSDARG00000061357Danio rerio
 CHST4ENSGALG00000000901Gallus gallus
 CHST4ENSG00000140835Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Chst5 / Q9QUP4 / Carbohydrate sulfotransferase 5 / CHST6* / Q9GZS9* / Q9GZX3* / carbohydrate sulfotransferase 6*ENSMUSG0000003195252
Chst7 / Q9EP78 / Carbohydrate sulfotransferase 7 / Q9NS84*ENSMUSG0000003734736
Chst2 / Q80WV3 / Carbohydrate sulfotransferase 2 / Q9Y4C5*ENSMUSG0000003335033
Chst1 / Q9EQC0 / Carbohydrate sulfotransferase 1 / O43916*ENSMUSG0000002722130
Chst3 / O88199 / Carbohydrate sulfotransferase 3 / Q7LGC8*ENSMUSG0000005733729


Protein motifs (from Interpro)
Interpro ID Name
 IPR000863  Sulfotransferase domain
 IPR016469  Carbohydrate sulfotransferase
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006044 N-acetylglucosamine metabolic process IEA
 biological_processGO:0006790 sulfur compound metabolic process IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005802 trans-Golgi network IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity IEA
 molecular_functionGO:0008146 sulfotransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
O-linked glycosylation of mucins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002339 abnormal lymph node morphology "anomalous structure, size, or celluarity of the oval or bean shaped bodies located along the lymphatic system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002345 abnormal lymph node primary follicle "anomaly in the immunologically inactive B cell area of the lymph node cortex" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003156 abnormal lymphocyte migration/homing "altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]
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Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Chst4tm1Mifu/Chst4tm1Mifu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Chst4tm1Mifu/Chst4tm1Mifu,Gcnt1tm1Jxm/Gcnt1tm1Jxm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Chst1tm1(KOMP)Vlcg/Chst1tm1(KOMP)Vlcg,Chst2tm1Tmu/Chst2tm1Tmu,Chst4tm1Sdr/Chst4tm1Sdr
Genetic Background: involves: 129S2/SvPas * C57BL/6NTac

Allelic Composition: Chst2tm1Tmu/Chst2tm1Tmu,Chst4tm1Sdr/Chst4tm1Sdr
Genetic Background: involves: 129S2/SvPas

 MP:0003628 abnormal lymphocyte adhesion "anomaly in the number of or process by which lymphocytes adhere to the luminal aspects of high endothelial venules prior to transmigration out of the vessel" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95656]
Show

Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0020332 impaired leukocyte tethering or rolling "reduced ability or inability in the transient adhesive interactions between leukocytes and endothelial cells lining blood vessels mediated primarily by selectins and which are typically the first step in cellular extravasation" [GO:0050901, ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Chst4tm1Mifu/Chst4tm1Mifu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Chst4tm1Mifu/Chst4tm1Mifu,Gcnt1tm1Jxm/Gcnt1tm1Jxm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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