ENSMUSG00000036882


Mus musculus

Features
Gene ID: ENSMUSG00000036882
  
Biological name :Arhgap33
  
Synonyms : Arhgap33 / Q80YF9 / Rho GTPase-activating protein 33
  
Possible biological names infered from orthology : O14559
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B1
Gene start: 30522226
Gene end: 30535060
  
Corresponding Affymetrix probe sets: 10561958 (MoGene1.0st)   1455701_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000146766
Ensembl peptide - ENSMUSP00000146602
Ensembl peptide - ENSMUSP00000146767
Ensembl peptide - ENSMUSP00000147001
Ensembl peptide - ENSMUSP00000038412
Ensembl peptide - ENSMUSP00000146571
NCBI entrez gene - 233071     See in Manteia.
MGI - MGI:2673998
RefSeq - XM_017322167
RefSeq - NM_001289670
RefSeq - NM_001289682
RefSeq - NM_178252
RefSeq - XM_006539888
RefSeq - XM_011250546
RefSeq - XM_011250547
RefSeq Peptide - NP_839983
RefSeq Peptide - NP_001276611
RefSeq Peptide - NP_001276599
swissprot - A0A140LHW2
swissprot - Q80YF9
swissprot - A0A140LIY1
swissprot - A0A140LIC8
Ensembl - ENSMUSG00000036882
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arhgap33ENSDARG00000011333Danio rerio
 O14559ENSG00000004777Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q811P8 / Arhgap32 / Rho GTPase-activating protein 32 / A7KAX9*ENSMUSG0000004144443
A6X8Z5 / Arhgap31 / Rho GTPase activating protein 31 / Q2M1Z3*ENSMUSG0000002279920
Arhgap30 / Rho GTPase activating protein 30 / Q7Z6I6*ENSMUSG0000004886519
Q3TBD2 / Arhgap45 / Mus musculus Rho GTPase activating protein 45 (Arhgap45), transcript variant 3, mRNA. / Q92619* / Rho GTPase activating protein 45*ENSMUSG0000003569710
Gmip / Q6PGG2 / Gem-interacting protein / Q9P107*ENSMUSG0000003624610
Q8CGF1 / Arhgap29 / Mus musculus Rho GTPase activating protein 29 (Arhgap29), transcript variant 2, mRNA. / Q52LW3* / Rho GTPase activating protein 29*ENSMUSG0000003983110
Q6Y5D8 / Arhgap10 / Rho GTPase-activating protein 10 / A1A4S6*ENSMUSG000000371489
B2RQE8 / Arhgap42 / Rho GTPase activating protein 42 / A6NI28* / Q9H2Q1*ENSMUSG000000507309
Q9WVM1 / Racgap1 / Rac GTPase-activating protein 1 / Q9H0H5*ENSMUSG000000230158
Q62172 / Ralbp1 / ralA binding protein 1 / Q15311*ENSMUSG000000240968
Ophn1 / Q99J31 / Oligophrenin-1 / O60890*ENSMUSG000000312148
Q6ZQ82 / Arhgap26 / Rho GTPase activating protein 26 / Q9UNA1*ENSMUSG000000364528


Protein motifs (from Interpro)
Interpro ID Name
 IPR000198  Rho GTPase-activating protein domain
 IPR001452  SH3 domain
 IPR008936  Rho GTPase activation protein
 IPR035510  Rho GTPase-activating protein 33
 IPR036028  SH3-like domain superfamily
 IPR036871  PX domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007264 small GTPase mediated signal transduction IBA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005938 cell cortex IBA
 cellular_componentGO:0015629 actin cytoskeleton IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0005096 GTPase activator activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019901 protein kinase binding ISO
 molecular_functionGO:0035091 phosphatidylinositol binding IEA


Pathways (from Reactome)
Pathway description
Rho GTPase cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
Show

Allelic Composition: Ptbp2Gt(NPX210)Byg/Ptbp2Gt(NPX210)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Ptbp2Gt(NPX210)Byg/Ptbp2Gt(NPX210)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0000794 abnormal parietal lobe morphology "malformation or absence of the upper central part of the cerebral hemisphere" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ptbp2Gt(NPX210)Byg/Ptbp2Gt(NPX210)Byg
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Arhgap33tm1.1Wbm/Arhgap33tm1.1Wbm,Cdc42tm1Brak/Cdc42+,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000805 abnormal visual cortex morphology "malformation or absence of the area of the occipital cortex concerned with vision" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ptbp2Gt(NPX210)Byg/Ptbp2Gt(NPX210)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0000859 abnormal somatosensory cortex morphology "any malformation or absence of the area of the parietal lobe that lies posterior to the central sulcus and is concerned with receiving and processing general sensations from the body surface" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptbp2Gt(NPX210)Byg/Ptbp2Gt(NPX210)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
Show

Allelic Composition: Apptm1b(KOMP)Wtsi/App+
Genetic Background: C57BL/6N-Apptm1b(KOMP)Wtsi/Ics

 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Apptm1b(KOMP)Wtsi/App+
Genetic Background: C57BL/6N-Apptm1b(KOMP)Wtsi/Ics

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apptm1b(KOMP)Wtsi/App+
Genetic Background: C57BL/6N-Apptm1b(KOMP)Wtsi/Ics

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Ptbp2Gt(NPX210)Byg/Ptbp2Gt(NPX210)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0004631 abnormal auditory cortex morphology "any structural abnormality in the region of the cerebral cortex that receives the auditory radiation from the medial geniculate body, a thalamic cell group receiving auditory input from the cochlear nuclei in the rhombencephalon and is responsible for processing of auditory (sound) information" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptbp2Gt(NPX210)Byg/Ptbp2Gt(NPX210)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0005103 abnormal retinal pigmentation "anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Apptm1b(KOMP)Wtsi/App+
Genetic Background: C57BL/6N-Apptm1b(KOMP)Wtsi/Ics

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
Show

Allelic Composition: Ptbp2Gt(NPX210)Byg/Ptbp2Gt(NPX210)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptbp2Gt(NPX210)Byg/Ptbp2Gt(NPX210)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0008547 abnormal neocortex morphology "any structural anomaly of the larger part of the mammalian cerebral cortex, distinguished from the allocortex by being composed of a larger number of nerve cells arranged in six layers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.186.211.730.885.213.420]
Show

Allelic Composition: Ptbp2Gt(NPX210)Byg/Ptbp2Gt(NPX210)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Apptm1b(KOMP)Wtsi/App+
Genetic Background: C57BL/6N-Apptm1b(KOMP)Wtsi/Ics

 MP:0011953 prolonged PQ interval "increase in the length of time between the beginning of atrial depolarization and the end of atrial repolarization (or recovery), measured by the interval from the beginning of the P wave to the end of the Q wave" [MPD:Molly]
Show

Allelic Composition: Apptm1b(KOMP)Wtsi/App+
Genetic Background: C57BL/6N-Apptm1b(KOMP)Wtsi/Ics

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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